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Hematopoietic differentiation is characterized by a transient peak of entropy at a single-cell level
Autor:
Charles Dussiau, Agathe Boussaroque, Mathilde Gaillard, Clotilde Bravetti, Laila Zaroili, Camille Knosp, Chloé Friedrich, Philippe Asquier, Lise Willems, Laurent Quint, Didier Bouscary, Michaela Fontenay, Thibault Espinasse, Adriana Plesa, Pierre Sujobert, Olivier Gandrillon, Olivier Kosmider
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-15 (2022)
Abstract Background Mature blood cells arise from hematopoietic stem cells in the bone marrow by a process of differentiation along one of several different lineage trajectories. This is often represented as a series of discrete steps of increasing p
Externí odkaz:
https://doaj.org/article/0bd5e386706b47ca9523fe9d092e28ec
Hematopoietic differentiation is characterized by a transient peak of entropy at a single cell level
Autor:
Laurent Quint, Olivier Gandrillon, Charles Dussiau, Clotilde Bravetti, Laila Zaroili, Mathilde Gaillard, Thibault Espinasse, Agathe Boussaroque, Camille Knosp, Pierre Sujobert, Olivier Kosmider, Didier Bouscary, Philippe Asquier, Lise Willems, Michaela Fontenay, Adriana Plesa, Chloé Friedrich
Hematopoietic differentiation has been metaphorically represented as linear trajectories with discrete steps from hematopoietic stem cells to mature cells. While the transcriptional state of cells at the beginning or at the end of these trajectories
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b050a2dce82b1af681919c19bd9eb5bb
https://doi.org/10.1101/2021.04.30.442092
https://doi.org/10.1101/2021.04.30.442092