Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Philippe A. Robert"'
Autor:
Elena Bonaiti, Manuele G. Muraro, Philippe A. Robert, Jens Jakscha, Stefan Dirnhofer, Ivan Martin, Christoph T. Berger
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionVaccination is one of the most effective infection prevention strategies. Viruses with high mutation rates -such as influenza- escape vaccine-induced immunity and represent significant challenges to vaccine design. Influenza vaccine strai
Externí odkaz:
https://doaj.org/article/5949856ea1094b149351ddf090b1b5fa
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionA protective humoral response to pathogens requires the development of high affinity antibodies in germinal centers (GC). The combination of antigens available during immunization has a strong impact on the strength and breadth of the ant
Externí odkaz:
https://doaj.org/article/a6212b5a50a5482a911a812a65a24950
Autor:
Rahmad Akbar, Habib Bashour, Puneet Rawat, Philippe A. Robert, Eva Smorodina, Tudor-Stefan Cotet, Karine Flem-Karlsen, Robert Frank, Brij Bhushan Mehta, Mai Ha Vu, Talip Zengin, Jose Gutierrez-Marcos, Fridtjof Lund-Johansen, Jan Terje Andersen, Victor Greiff
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Although the therapeutic efficacy and commercial success of monoclonal antibodies (mAbs) are tremendous, the design and discovery of new candidates remain a time and cost-intensive endeavor. In this regard, progress in the generation of data describi
Externí odkaz:
https://doaj.org/article/aa3c08b3fb154e0dafa6136e2d38c0d4
Autor:
Rahmad Akbar, Philippe A. Robert, Cédric R. Weber, Michael Widrich, Robert Frank, Milena Pavlović, Lonneke Scheffer, Maria Chernigovskaya, Igor Snapkov, Andrei Slabodkin, Brij Bhushan Mehta, Enkelejda Miho, Fridtjof Lund-Johansen, Jan Terje Andersen, Sepp Hochreiter, Ingrid Hobæk Haff, Günter Klambauer, Geir Kjetil Sandve, Victor Greiff
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Generative machine learning (ML) has been postulated to become a major driver in the computational design of antigen-specific monoclonal antibodies (mAb). However, efforts to confirm this hypothesis have been hindered by the infeasibility of testing
Externí odkaz:
https://doaj.org/article/dcc3e950ba4a40b789231de4ffed3cb1
Autor:
Anastasios Siokis, Philippe A. Robert, Philippos Demetriou, Audun Kvalvaag, Salvatore Valvo, Viveka Mayya, Michael L. Dustin, Michael Meyer-Hermann
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103100- (2021)
Summary: Small immunoglobulin superfamily (sIGSF) adhesion complexes form a corolla of microdomains around an integrin ring and secretory core during immunological synapse (IS) formation. The corolla recruits and retains major costimulatory/checkpoin
Externí odkaz:
https://doaj.org/article/1961a091187641ce8d77cb84243f0b4a
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102979- (2021)
Summary: Vaccine development is challenged by the hierarchy of immunodominance between target antigen epitopes and the emergence of antigenic variants by pathogen mutation. The strength and breadth of antibody responses relies on selection and mutati
Externí odkaz:
https://doaj.org/article/4723cada864e4883b99f3f40019c7066
Autor:
Elena Merino Tejero, Danial Lashgari, Rodrigo García-Valiente, Jiaojiao He, Philippe A. Robert, Michael Meyer-Hermann, Jeroen E. J. Guikema, Huub Hoefsloot, Antoine H. C. van Kampen
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Memory B cells and antibody-secreting plasma cells are generated within germinal centers during affinity maturation in which B-cell proliferation, selection, differentiation, and self-renewal play important roles. The mechanisms behind memory B cell
Externí odkaz:
https://doaj.org/article/95d6e5d3f1104c14a97c91b1ef30aab6
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Germinal Centres (GCs) are transient structures in secondary lymphoid organs, where affinity maturation of B cells takes place following an infection. While GCs are responsible for protective antibody responses, dysregulated GC reactions are associat
Externí odkaz:
https://doaj.org/article/2bc75c0e216c4fe9adbf7be4289cf90d
Autor:
Elena Merino Tejero, Danial Lashgari, Rodrigo García-Valiente, Xuefeng Gao, Fabien Crauste, Philippe A. Robert, Michael Meyer-Hermann, María Rodríguez Martínez, S. Marieke van Ham, Jeroen E. J. Guikema, Huub Hoefsloot, Antoine H. C. van Kampen
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Germinal centers play a key role in the adaptive immune system since they are able to produce memory B cells and plasma cells that produce high affinity antibodies for an effective immune protection. The mechanisms underlying cell-fate decisions are
Externí odkaz:
https://doaj.org/article/b71fd22486ec46cba1fbea77e5755481
Autor:
Agnes Bonifacius, Oliver Goldmann, Stefan Floess, Silva Holtfreter, Philippe A. Robert, Maria Nordengrün, Friederike Kruse, Matthias Lochner, Christine S. Falk, Ingo Schmitz, Barbara M. Bröker, Eva Medina, Jochen Huehn
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Staphylococcus aureus can cause life-threatening diseases, and hospital- as well as community-associated antibiotic-resistant strains are an emerging global public health problem. Therefore, prophylactic vaccines or immune-based therapies are conside
Externí odkaz:
https://doaj.org/article/ecb0f7bd7d2c4295a7d1dae990335be1