Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Philippe A. Halban"'
Autor:
Sabine Rütti, Cédric Howald, Caroline Arous, Emmanouil Dermitzakis, Philippe A. Halban, Karim Bouzakri
Publikováno v:
Molecular Metabolism, Vol 5, Iss 2, Pp 122-131 (2016)
Objectives: IL-13 is a cytokine classically produced by anti-inflammatory T-helper-2 lymphocytes; it is decreased in the circulation of type 2 diabetic patients and impacts positively on liver and skeletal muscle. Although IL-13 can exert positive ef
Externí odkaz:
https://doaj.org/article/8e0c7ed990ad425586b6ab9b4b6381f1
Autor:
Sabine Rutti, Caroline Arous, Domitille Schvartz, Katharina Timper, Jean-Charles Sanchez, Emmanouil Dermitzakis, Marc Y. Donath, Philippe A. Halban, Karim Bouzakri
Publikováno v:
Molecular Metabolism, Vol 3, Iss 7, Pp 731-741 (2014)
Objective: We have previously shown the existence of a muscle–pancreas intercommunication axis in which CX3CL1 (fractalkine), a CX3C chemokine produced by skeletal muscle cells, could be implicated. It has recently been shown that the fractalkine s
Externí odkaz:
https://doaj.org/article/176116c7644840538eb8d3a9a4861501
Autor:
Philippe A. Halban, Caroline Arous
Publikováno v:
American Journal of Physiology Endocrinology Metabolism
Over the last few decades, biomedical research has considered not only the function of single cells but also the importance of the physical environment within a whole tissue, including cell-cell and cell-extracellular matrix interactions. Cytoskeleto
Autor:
Frédéric Ris, Jose Oberholzer, Giatgen A. Spinas, Helen I. Joller-Jemelka, Nurit Kaiser, Marc Y. Donath, Pavel Sergeev, Kathrin Maedler, Philippe A. Halban
Publikováno v:
Journal of Clinical Investigation, Vol. 110, No 6 (2002) pp. 851-860
In type 2 diabetes, chronic hyperglycemia is suggested to be detrimental to pancreatic beta cells, causing impaired insulin secretion. IL-1beta is a proinflammatory cytokine acting during the autoimmune process of type 1 diabetes. IL-1beta inhibits b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688d54d567d48a8372791ef68a5760b7
https://doi.org/10.5167/uzh-208352
https://doi.org/10.5167/uzh-208352
Publikováno v:
Diabetologia, Vol. 56, No 3 (2013) pp. 439-43
Today, European biomedical and health-related research is insufficiently well funded and is fragmented, with no common vision, less-than-optimal sharing of resources, and inadequate support and training in clinical research. Improvements to the compe
Autor:
Sabine Rütti, Karim Bouzakri, Jens Otto Clemmesen, Cora Weigert, Caroline Arous, Bente Klarlund Pedersen, Philippe A. Halban, Carmen Gonelle-Gispert, Jakob S. Hansen, Niels H. Secher, Andrea Drescher, Peter Plomgaard
Publikováno v:
J. Clin. Endocrinol. Metab. 101, 550-560 (2016)
Context: Follistatin is a plasma protein recently reported to increase under conditions with negative energy balance, such as exercise and fasting in humans. Currently, the perception is that circulating follistatin is a result of para/autocrine acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9e008d0b4d1c56d4bc35e67436cec1
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=49073
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=49073
Publikováno v:
Diabetes Obesity and Metabolism
Diabetes, Obesity and Metabolism, Vol. 14 Suppl 3 (2012) pp. 78-84
Diabetes, Obesity and Metabolism, Vol. 14 Suppl 3 (2012) pp. 78-84
Diabetes is a complex disease that affects many organs directly or indirectly. Type 2 diabetes mellitus is characterized by insulin resistance with a relative deficiency in insulin secretion. It has become apparent that inter-organ communication is o
Autor:
Philippe A. Halban, Dieter Rondas, Martinho Soto-Ribeiro, Bernhard Wehrle-Haller, Alejandra Tomas
Publikováno v:
The Journal of biological chemistry
Journal of Biological Chemistry, Vol. 287, No 4 (2012) pp. 2423-36
Journal of Biological Chemistry, Vol. 287, No 4 (2012) pp. 2423-36
Actin cytoskeleton remodeling is well known to be positively involved in glucose-stimulated pancreatic beta cell insulin secretion. We have observed glucose-stimulated focal adhesion remodeling at the beta cell surface and have shown this to be cruci
Autor:
S. Calderari, Nadim Kassis, Christophe Noll, Micheline Kergoat, M. Cornut, M.H. Giroix, Fabien Schmidlin, Jean-Louis Paul, Jean-Claude Irminger, Nathalie Janel, Josiane Coulaud, Gregory Lacraz, Philippe A. Halban, Françoise Homo-Delarche, Jan A. Ehses
Publikováno v:
Diabetologia
Diabetologia, Springer Verlag, 2011, 54 (9), pp.2451-2462. ⟨10.1007/s00125-011-2223-4⟩
Diabetologia, Vol. 54, No 9 (2011) pp. 2451-62
Diabetologia, 2011, 54 (9), pp.2451-2462. ⟨10.1007/s00125-011-2223-4⟩
Diabetologia, Springer Verlag, 2011, 54 (9), pp.2451-2462. ⟨10.1007/s00125-011-2223-4⟩
Diabetologia, Vol. 54, No 9 (2011) pp. 2451-62
Diabetologia, 2011, 54 (9), pp.2451-2462. ⟨10.1007/s00125-011-2223-4⟩
International audience; The adult non-obese Goto–Kakizaki (GK) rat model of type 2 diabetes, particularly females, carries in addition to hyperglycaemia a genetic predisposition towards dyslipidaemia, including hypercholesterolaemia. As cholesterol
Autor:
Philippe A. Halban, Sarah Hills
Publikováno v:
Journal of Diabetes Science and Technology. 5:794-797
The DIAMAP Project, which has drawn up a road map for diabetes research in Europe, has now concluded, and the results are available in the form of a report and searchable databases. The DIAMAP road maps provide strategic guidance for diabetes researc