Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Philippe A. Gallay"'
Autor:
Jeremy R. A. Paull, Carolyn A. Luscombe, Aynaz Seta, Graham P. Heery, Michael D. Bobardt, Philippe A. Gallay, Samuel Constant, Alex Castellarnau
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract COVID-19 remains a severe condition for many including immunocompromised individuals. There remains a need for effective measures against this and other respiratory infections, which transmit via virus-laden droplets that reach the nasal or
Externí odkaz:
https://doaj.org/article/8e228549e15843db901c880e806a7a89
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Cyclophilins (Cyps), characterized as peptidyl-prolyl cis-trans isomerases (PPIases), are highly conserved and ubiquitous, playing a crucial role in protein folding and cellular signaling. This review summarizes the biochemical pathways mediated by C
Externí odkaz:
https://doaj.org/article/0ba02b5046a340a08ec726aee8d3084b
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Adolescent girls and young women in low- to middle-income countries are disproportionately at risk of becoming HIV-1 infected. New non-vaccine biomedical products aimed at overcoming this global health challenge need to provide a range of sa
Externí odkaz:
https://doaj.org/article/d89efe998a1f416bb945efbcd856d8c0
Autor:
Manjula Gunawardana, Simon Webster, Sofia Rivera, John M. Cortez, Jessica Breslin, Cristian Pinales, Christopher Buser, F. Javier Ibarrondo, Otto O. Yang, Michael Bobardt, Philippe A. Gallay, Amy P. Adler, Christina M. Ramirez, Peter A. Anton, Marc M. Baum
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-15 (2022)
Gunawardana et al. monitor the viral load, inflammatory biomarkers and antibody response long-term in people who developed COVID-19. Early viral replication is rapid, providing a narrow window between exposure and viral shedding.
Externí odkaz:
https://doaj.org/article/187c9b42f527479593dad780d47761f3
Autor:
Manjula Gunawardana, Mariana Remedios-Chan, Debbie Sanchez, Simon Webster, Amalia E. Castonguay, Paul Webster, Christopher Buser, John A. Moss, MyMy Trinh, Martin Beliveau, Craig W. Hendrix, Mark A. Marzinke, Michael Tuck, Richard M. Caprioli, Michelle L. Reyzer, Joseph Kuo, Philippe A. Gallay, Marc M. Baum
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-25 (2022)
Abstract Global efforts aimed at preventing human immunodeficiency virus type one (HIV-1) infection in vulnerable populations appear to be stalling, limiting our ability to control the epidemic. Long-acting, controlled drug administration from subder
Externí odkaz:
https://doaj.org/article/d352387a823744fc941959d7d0cbe1eb
Multispecies Evaluation of a Long-Acting Tenofovir Alafenamide Subdermal Implant for HIV Prophylaxis
Autor:
Manjula Gunawardana, Mariana Remedios-Chan, Debbie Sanchez, Simon Webster, Patricia Galvan, Rob Fanter, Amalia E. Castonguay, Paul Webster, John A. Moss, Joseph Kuo, Philippe A. Gallay, Kathleen L. Vincent, Massoud Motamedi, Dana Weinberger, Mark A. Marzinke, Craig W. Hendrix, Marc M. Baum
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
New HIV-1 infection rates far outpace the targets set by global health organizations, despite important progress in curbing the progression of the epidemic. Long-acting (LA) formulations delivering antiretroviral (ARV) agents for HIV-1 pre-exposure p
Externí odkaz:
https://doaj.org/article/f61e7354b58c4d35828203f2c4470553
Autor:
Jeremy R. A. Paull, Carolyn A. Luscombe, Alex Castellarnau, Graham P. Heery, Michael D. Bobardt, Philippe A. Gallay
Publikováno v:
Viruses, Vol 13, Iss 8, p 1656 (2021)
Strategies to combat COVID-19 require multiple ways to protect vulnerable people from infection. SARS-CoV-2 is an airborne pathogen and the nasal cavity is a primary target of infection. The K18-hACE2 mouse model was used to investigate the anti-SARS
Externí odkaz:
https://doaj.org/article/1bc831e5c6b349fd9e86ebaee91475c4
Autor:
Brigitte Rosenwirth, Jean-Maurice Dumont, Grégoire Vuagniaux, Michael D. Bobardt, Philippe A. Gallay, Roger G. Ptak
Publikováno v:
Viruses, Vol 5, Iss 3, Pp 981-997 (2013)
DEB025 (alisporivir) is a synthetic cyclosporine with inhibitory activity against human immunodeficiency virus type-1 (HIV-1) and hepatitis C virus (HCV). It binds to cyclophilin A (CypA) and blocks essential functions of CypA in the viral replicatio
Externí odkaz:
https://doaj.org/article/2482db037e7b462e9f372e0cb101db58
Autor:
Manjula Gunawardana, Mariana Remedios-Chan, Debbie Sanchez, Rob Fanter, Simon Webster, Paul Webster, John A. Moss, MyMy Trinh, Martin Beliveau, Christina M. Ramirez, Mark A. Marzinke, Joseph Kuo, Philippe A. Gallay, Marc M. Baum
Publikováno v:
Pharmaceutical research.
Purpose Long-acting formulations of the potent antiretroviral prodrug tenofovir alafenamide (TAF) hold potential as biomedical HIV prevention modalities. Here, we present a rigorous comparison of three animal models, C57BL/6 J mice, beagle dogs, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a3d0d00817bdd3a383b8c6d902f903
https://pubmed.ncbi.nlm.nih.gov/36418671
https://pubmed.ncbi.nlm.nih.gov/36418671
Autor:
Manjula Gunawardana, Mariana Remedios-Chan, Debbie Sanchez, Simon Webster, Amalia E. Castonguay, Paul Webster, Christopher Buser, John A. Moss, MyMy Trinh, Martin Beliveau, Craig W. Hendrix, Mark A. Marzinke, Michael Tuck, Richard M. Caprioli, Michelle L. Reyzer, Joseph Kuo, Philippe A. Gallay, Marc M. Baum
Publikováno v:
Scientific reports. 12(1)
Global efforts aimed at preventing human immunodeficiency virus type one (HIV-1) infection in vulnerable populations appear to be stalling, limiting our ability to control the epidemic. Long-acting, controlled drug administration from subdermal impla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f20046191df4433bbc95e7a4909929f6
https://pubmed.ncbi.nlm.nih.gov/35581262
https://pubmed.ncbi.nlm.nih.gov/35581262