Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Philippe A Parone"'
Autor:
Shuo-Chien Ling, Somasish Ghosh Dastidar, Seiya Tokunaga, Wan Yun Ho, Kenneth Lim, Hristelina Ilieva, Philippe A Parone, Sheue-Houy Tyan, Tsemay M Tse, Jer-Cherng Chang, Oleksandr Platoshyn, Ngoc B Bui, Anh Bui, Anne Vetto, Shuying Sun, Melissa McAlonis-Downes, Joo Seok Han, Debbie Swing, Katannya Kapeli, Gene W Yeo, Lino Tessarollo, Martin Marsala, Christopher E Shaw, Greg Tucker-Kellogg, Albert R La Spada, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Don W Cleveland
Publikováno v:
eLife, Vol 8 (2019)
Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis (ALS). The latter mutations may exert toxicity by increasing FUS accumulation. We show here that broad expression within the nervous system of wild-type or either o
Externí odkaz:
https://doaj.org/article/04213ee8809d4946acefc96cd36ba9b2
Autor:
Philippe A Parone, Sandrine Da Cruz, Daniel Tondera, Yves Mattenberger, Dominic I James, Pierre Maechler, François Barja, Jean-Claude Martinou
Publikováno v:
PLoS ONE, Vol 3, Iss 9, p e3257 (2008)
Mitochondria form a highly dynamic tubular network, the morphology of which is regulated by frequent fission and fusion events. However, the role of mitochondrial fission in homeostasis of the organelle is still unknown. Here we report that preventin
Externí odkaz:
https://doaj.org/article/30d4572743f44d3280a1e26a703bec07
Autor:
Martin Marsala, Shuying Sun, Ngoc B. Bui, Tsemay M. Tse, Shuo-Chien Ling, Greg Tucker-Kellogg, Gene W. Yeo, Philippe A. Parone, Hristelina Ilieva, Seiya Tokunaga, Christopher Shaw, Sandrine Da Cruz, Oleksandr Platoshyn, Kenneth Lim, Somasish Ghosh Dastidar, Don W. Cleveland, Clotilde Lagier-Tourenne, Debbie Swing, Joo Seok Han, Albert R. La Spada, Anh Bui, Wan Yun Ho, Lino Tessarollo, Jer-Cherng Chang, Melissa McAlonis-Downes, Sheue-Houy Tyan, Anne P. Vetto, Katannya Kapeli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6336cbcf1decdbc907883e7a0b14a4f7
https://doi.org/10.7554/elife.40811.039
https://doi.org/10.7554/elife.40811.039
Autor:
Zhengyu Ouyang, Clotilde Lagier-Tourenne, Lino Tessarollo, Geoffrey G. Hicks, Melissa McAlonis-Downes, Joshua N. Asiaban, Martin Marsala, Jone López-Erauskin, Brian Myers, Takahiro Tadokoro, Anne P. Vetto, Jihane Boubaker, Philippe A. Parone, Mélanie Jambeau, Don W. Cleveland, Jonathan W. Artates, Christopher Shaw, Carlos Chillon-Marinas, Xiang-Dong Fu, Ai Vy Le, Ying Sun, Shuo-Chien Ling, Michael Baughn, Deborah A. Swing, Sandra K. Lee, Anh Bui, Sandrine Da Cruz, Jinsong Qiu
Publikováno v:
Neuron, vol 100, iss 4
Neuron
Neuron
Summary Through the generation of humanized FUS mice expressing full-length human FUS, we identify that when expressed at near endogenous murine FUS levels, both wild-type and ALS-causing and frontotemporal dementia (FTD)-causing mutations complement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f2bc70ed48964ac7c969fd50f4a022
https://escholarship.org/uc/item/1xc9h7bm
https://escholarship.org/uc/item/1xc9h7bm
Autor:
Kenneth Lim, Shuying Sun, Sandrine Da Cruz, Debbie Swing, Wan Yun Ho, Philippe A. Parone, Ngoc B. Bui, Jer Cherng Chang, Clotilde Lagier-Tourenne, Joo Seok Han, Albert R. La Spada, Hristelina Ilieva, Anh Bui, Melissa McAlonis-Downes, Katannya Kapeli, Don W. Cleveland, Seiya Tokunaga, Greg Tucker-Kellogg, Martin Marsala, Christopher Shaw, Oleksandr Platoshyn, Somasish Ghosh Dastidar, Tsemay M. Tse, Shuo-Chien Ling, Gene W. Yeo, Sheue Houy Tyan, Lino Tessarollo, Anne P. Vetto
Publikováno v:
Autophagy
eLife, Vol 8 (2019)
eLife
eLife, Vol 8 (2019)
eLife
Coding or non-coding mutations in FUS (fused in sarcoma) cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). In addition to familial ALS, abnormal aggregates of FUS are present in a portion of FTD and other neurodegenerative
Autor:
Donald P. Pizzo, Don W. Cleveland, Philippe A. Parone, Derek Schulte, Melissa McAlonis-Downes, John Ravits, Anh Bui, Sandrine Da Cruz, Jennifer E. Stauffer, Shahram Saberi, Sandra K. Lee
Publikováno v:
Acta neuropathologica, vol 134, iss 1
A common feature of inherited and sporadic ALS is accumulation of abnormal proteinaceous inclusions in motor neurons and glia. SOD1 is the major protein component accumulating in patients with SOD1 mutations, as well as in mutant SOD1 mouse models. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4df11a7fcb1b01af2ddd29b1d712a48
https://escholarship.org/uc/item/9ch9c08j
https://escholarship.org/uc/item/9ch9c08j
Publikováno v:
Bio-protocol, vol 3, iss 21
Mitochondria are eukaryotic organelles that play a crucial role in several cellular processes, including energy production, β-oxidation of fatty acids and regulation of calcium homeostasis. In the last 20 years there has been a hightened interest in
Autor:
Philippe A. Parone, Don W. Cleveland, Sandrine Da Cruz, Anne P. Vetto, Joo Seok Han, Melissa McAlonis-Downes, Eva Tseng, Sandra K. Lee
Publikováno v:
The Journal of Neuroscience. 33:4657-4671
Mitochondria have been proposed as targets for toxicity in amyotrophic lateral sclerosis (ALS), a progressive, fatal adult-onset neurodegenerative disorder characterized by the selective loss of motor neurons. A decrease in the capacity of spinal cor
Autor:
A. A. Ustyugov, I. L. Goldman, Hannah K. Robinson, Alexey V. Deykin, Philippe A. Parone, E. A. Kovrazhkina, Owen M. Peters, T G Ermolkevich, Vladimir L. Buchman, Veronica I. Skvortsova, Shuo-Chien Ling, Natalia Ninkina, Tatyana A. Shelkovnikova, Sergey O. Bachurin, E. R. Sadchikova, Natalie Connor-Robson, Sandrine Da Cruz
Publikováno v:
The Journal of Biological Chemistry
Background: FUS inclusions are hallmarks of certain neurodegenerative diseases. Results: Expression of a highly aggregate prone FUS variant in transgenic mice causes proteinopathy and severe motor phenotype. Conclusion: Aggregation of FUS is sufficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3df383d4df90792d03e86efd8b482c
https://doi.org/10.1074/jbc.m113.492017
https://doi.org/10.1074/jbc.m113.492017
Autor:
Maud Frieden, Umberto De Marchi, Philippe A. Parone, Jean-Claude Martinou, Sandrine Da Cruz, Nicolas Demaurex
Publikováno v:
Cell calcium
Cell Calcium, Vol. 47, No 1 (2010) pp. 11-18
Cell Calcium, Vol. 47, No 1 (2010) pp. 11-18
Mitochondria play a major role in cellular calcium homeostasis. Despite decades of studies, the molecules that mediate and regulate the transport of calcium ions in and out of the mitochondrial matrix remain unknown. Here, we investigate whether SLP-