Fractalkine (CX3CL1), a new factor protecting β-cells against TNFα

Autor: Sabine Rutti, Caroline Arous, Domitille Schvartz, Katharina Timper, Jean-Charles Sanchez, Emmanouil Dermitzakis, Marc Y. Donath, Philippe A. Halban, Karim Bouzakri

Publikováno v: Molecular Metabolism, Vol 3, Iss 7, Pp 731-741 (2014)

Objective: We have previously shown the existence of a muscle–pancreas intercommunication axis in which CX3CL1 (fractalkine), a CX3C chemokine produced by skeletal muscle cells, could be implicated. It has recently been shown that the fractalkine s

Externí odkaz: https://doaj.org/article/176116c7644840538eb8d3a9a4861501

The skeleton in the closet: actin cytoskeletal remodeling in β-cell function

Autor: Philippe A. Halban, Caroline Arous

Publikováno v: American Journal of Physiology Endocrinology Metabolism

Over the last few decades, biomedical research has considered not only the function of single cells but also the importance of the physical environment within a whole tissue, including cell-cell and cell-extracellular matrix interactions. Cytoskeleto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629bab538cc822addb61a986de66cc5c
https://doi.org/10.1152/ajpendo.00268.2015

Circulating follistatin is liver-derived and regulated by the glucagon-to-insulin ratio

Autor: Sabine Rütti, Karim Bouzakri, Jens Otto Clemmesen, Cora Weigert, Caroline Arous, Bente Klarlund Pedersen, Philippe A. Halban, Carmen Gonelle-Gispert, Jakob S. Hansen, Niels H. Secher, Andrea Drescher, Peter Plomgaard

Publikováno v: J. Clin. Endocrinol. Metab. 101, 550-560 (2016)

Context: Follistatin is a plasma protein recently reported to increase under conditions with negative energy balance, such as exercise and fasting in humans. Currently, the perception is that circulating follistatin is a result of para/autocrine acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9e008d0b4d1c56d4bc35e67436cec1
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=49073

Bimodal impact of skeletal muscle on pancreatic β-cell function in health and disease

Autor: Philippe A. Halban, Peter Plomgaard, Karim Bouzakri

Publikováno v: Diabetes Obesity and Metabolism
Diabetes, Obesity and Metabolism, Vol. 14 Suppl 3 (2012) pp. 78-84

Diabetes is a complex disease that affects many organs directly or indirectly. Type 2 diabetes mellitus is characterized by insulin resistance with a relative deficiency in insulin secretion. It has become apparent that inter-organ communication is o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54fa260165cfbf1da183921739af5044
https://doi.org/10.1111/j.1463-1326.2012.01641.x

Hypercholesterolaemia, signs of islet microangiopathy and altered angiogenesis precede onset of type 2 diabetes in the Goto–Kakizaki (GK) rat

Autor: S. Calderari, Nadim Kassis, Christophe Noll, Micheline Kergoat, M. Cornut, M.H. Giroix, Fabien Schmidlin, Jean-Louis Paul, Jean-Claude Irminger, Nathalie Janel, Josiane Coulaud, Gregory Lacraz, Philippe A. Halban, Françoise Homo-Delarche, Jan A. Ehses

Publikováno v: Diabetologia
Diabetologia, Springer Verlag, 2011, 54 (9), pp.2451-2462. ⟨10.1007/s00125-011-2223-4⟩
Diabetologia, Vol. 54, No 9 (2011) pp. 2451-62
Diabetologia, 2011, 54 (9), pp.2451-2462. ⟨10.1007/s00125-011-2223-4⟩

International audience; The adult non-obese Goto–Kakizaki (GK) rat model of type 2 diabetes, particularly females, carries in addition to hyperglycaemia a genetic predisposition towards dyslipidaemia, including hypercholesterolaemia. As cholesterol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba7cd0f6778f7d427f942b84889e7e8
https://doi.org/10.1007/s00125-011-2223-4