Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Philippe A Gallay"'
Autor:
Michael Bobardt, Christina M Ramirez, Marc M Baum, Daren Ure, Robert Foster, Philippe A Gallay
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251934 (2021)
We and others previously reported that the direct-acting agents (DAA) NS5A inhibitors (NS5Ai) and the host-targeting agents cyclophilin inhibitors (CypIs) inhibit HCV replication in vitro. In this study, we investigated whether the combination of NS5
Externí odkaz:
https://doaj.org/article/fd6c7099ffba42e0862d69740429210b
Autor:
Michael Bobardt, Joseph Kuo, Udayan Chatterji, Sumit Chanda, Susan J Little, Norbert Wiedemann, Gregoire Vuagniaux, Philippe A Gallay
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211746 (2019)
Antiretroviral therapy (ART) suppresses HIV replication, but does not cure the infection because replication-competent virus persists within latently infected CD4+ T cells throughout years of therapy. These reservoirs contain integrated HIV-1 genomes
Externí odkaz:
https://doaj.org/article/631ad312baca467bacc1798777b5328e
Autor:
Jeremy R. A. Paull, Carolyn A. Luscombe, Aynaz Seta, Graham P. Heery, Michael D. Bobardt, Philippe A. Gallay, Samuel Constant, Alex Castellarnau
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract COVID-19 remains a severe condition for many including immunocompromised individuals. There remains a need for effective measures against this and other respiratory infections, which transmit via virus-laden droplets that reach the nasal or
Externí odkaz:
https://doaj.org/article/8e228549e15843db901c880e806a7a89
Autor:
Philippe A Gallay, Udayan Chatterji, Aaron Kirchhoff, Angel Gandarilla, Manjula Gunawardana, Richard B Pyles, Mark A Marzinke, John A Moss, Marc M Baum
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184303 (2017)
With more than 7,000 new HIV infections daily worldwide, there is an urgent need for non-vaccine biomedical prevention (nBP) strategies that are safe, effective, and acceptable. Clinical trials have demonstrated that pre-exposure prophylaxis (PrEP) w
Externí odkaz:
https://doaj.org/article/3d41b996c19f468aa0856e3cda969531
Autor:
Philippe A Gallay, Udayan Chatterji, Michael D Bobardt, Zhengyu Long, Shengli Zhang, Zhuang Su
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152036 (2016)
Shortened current direct-acting antiviral (DAA) therapies while less expensive, have not provided satisfactory efficacy in naïve cirrhotics, treatment experienced non-cirrhotics or even genotype-3 (GT3)-infected patients. Since DAA regimens consist
Externí odkaz:
https://doaj.org/article/b2e8dbbae74a49f4b2acec278ab77b11
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159511 (2016)
The mechanisms of action by which cyclophilin inhibitors (CypI) interfere with the HCV life cycle remain poorly understood. We reported that CypI and NS5A inhibitors (NS5Ai), but not other classes of anti-HCV agents, prevent assembly of double membra
Externí odkaz:
https://doaj.org/article/013c68ed09904a0a9e10ad5d8715fb21
Autor:
Philippe A Gallay, Michael D Bobardt, Udayan Chatterji, Daniel J Trepanier, Daren Ure, Cosme Ordonez, Robert Foster
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134707 (2015)
HCV-related liver disease is the main cause of morbidity and mortality of HCV/HIV-1 co-infected patients. Despite the recent advent of anti-HCV direct acting antivirals (DAAs), the treatment of HCV/HIV-1 co-infected patients remains a challenge, as t
Externí odkaz:
https://doaj.org/article/1b8d9a0cbe4f47dfa9addb58a1c373d8
Autor:
Katarzyna Gawlik, James Baugh, Udayan Chatterji, Precious J Lim, Michael D Bobardt, Philippe A Gallay
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88866 (2014)
Hepatitis C virus (HCV) infection is a major cause of liver disease. The molecular machinery of HCV assembly and particle release remains obscure. A better understanding of the assembly events might reveal new potential antiviral strategies. It was s
Externí odkaz:
https://doaj.org/article/ba20fa920f354e6682312ceca21fe959
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Cyclophilins (Cyps), characterized as peptidyl-prolyl cis-trans isomerases (PPIases), are highly conserved and ubiquitous, playing a crucial role in protein folding and cellular signaling. This review summarizes the biochemical pathways mediated by C
Externí odkaz:
https://doaj.org/article/0ba02b5046a340a08ec726aee8d3084b
Autor:
Lot de Witte, Michael D Bobardt, Udayan Chatterji, Freek B van Loenen, Georges M G M Verjans, Teunis B H Geijtenbeek, Philippe A Gallay
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e18917 (2011)
Genital herpes is a major risk factor in acquiring human immunodeficiency virus type-1 (HIV-1) infection and is caused by both Herpes Simplex virus type 1 (HSV-1) and HSV-2. The amphipathic peptide C5A, derived from the non-structural hepatitis C vir
Externí odkaz:
https://doaj.org/article/dfd811b9dd314c93a21b3ec9524b244e