Allicin ameliorates glucose and lipid metabolism via modulation of gut microbiota and bile acid profile in diabetic rats

Autor: Zhibin Wang, Lina Ding, Junjun Liu, Philippe Savarin, Xiaolei Wang, Ke Zhao, Wenyu Ding, Yanli Hou

Publikováno v: Journal of Functional Foods, Vol 111, Iss , Pp 105899- (2023)

Diabetes mellitus is a widely prevalent chronic disease, and effective treatments for it remain limited. Allicin has anti-diabetic effect, however, the detailed mechanism has not been well investigated. The diabetic rats were treated with allicin for

Externí odkaz: https://doaj.org/article/bf31da1172944d8aa9d9ea06a208146e

Plasma Metabolomic and Lipidomic Profiling of Metabolic Dysfunction-Associated Fatty Liver Disease in Humans Using an Untargeted Multiplatform Approach

Autor: Xiangping Lin, Xinyu Liu, Mohamed N. Triba, Nadia Bouchemal, Zhicheng Liu, Douglas I. Walker, Tony Palama, Laurence Le Moyec, Marianne Ziol, Nada Helmy, Corinne Vons, Guowang Xu, Carina Prip-Buus, Philippe Savarin

Publikováno v: Metabolites, Vol 12, Iss 11, p 1081 (2022)

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a complex disorder that is implicated in dysregulations in multiple biological pathways, orchestrated by interactions between genetic predisposition, metabolic syndromes and environmenta

Externí odkaz: https://doaj.org/article/3066e620ff9f41aaaa40cf3aa2285fe6

Identification of a discriminative metabolomic fingerprint of potential clinical relevance in saliva of patients with periodontitis using 1H nuclear magnetic resonance (NMR) spectroscopy.

Autor: Matthias Rzeznik, Mohamed Nawfal Triba, Pierre Levy, Sébastien Jungo, Eliot Botosoa, Boris Duchemann, Laurence Le Moyec, Jean-François Bernaudin, Philippe Savarin, Dominique Guez

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0182767 (2017)

Periodontitis is characterized by the loss of the supporting tissues of the teeth in an inflammatory-infectious context. The diagnosis relies on clinical and X-ray examination. Unfortunately, clinical signs of tissue destruction occur late in the dis

Externí odkaz: https://doaj.org/article/531c4576ad6b4f1f9da540bf4c0a575a

Plasma Metabolomics for Discovery of Early Metabolic Markers of Prostate Cancer Based on Ultra-High-Performance Liquid Chromatography-High Resolution Mass Spectrometry

Autor: Mohamed N. Triba, Adrien Rossary, Serge Hercberg, Aicha Demidem, L. Lécuyer, Pilar Galan, Philippe Savarin, Xinyu Liu, Tony Lionel Palama, Mathilde Touvier, Mélanie Deschasaux-Tanguy, Guowang Xu, Marie-Paule Vasson, Zhicheng Liu, Xiangping Lin

Publikováno v: Cancers
Cancers, 2021, 13 (13), pp.3140. ⟨10.3390/cancers13133140⟩
Volume 13
Issue 13
Cancers, MDPI, 2021, 13 (13), pp.3140. ⟨10.3390/cancers13133140⟩
Cancers, Vol 13, Iss 3140, p 3140 (2021)

Background: The prevention and early screening of PCa is highly dependent on the identification of new biomarkers. In this study, we investigated whether plasma metabolic profiles from healthy males provide novel early biomarkers associated with futu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70416e0fec66bdb2e2dc1e84b2b0ac5
https://hal.inrae.fr/hal-03316278/document

Metabolic impact of anti-angiogenic agents on U87 glioma cells.

Autor: Tanja Mesti, Philippe Savarin, Mohamed N Triba, Laurence Le Moyec, Janja Ocvirk, Claire Banissi, Antoine F Carpentier

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e99198 (2014)

BACKGROUND: Glioma cells not only secrete high levels of vascular endothelial growth factor (VEGF) but also express VEGF receptors (VEGFR), supporting the existence of an autocrine loop. The direct impact on glioma cells metabolism of drugs targeting

Externí odkaz: https://doaj.org/article/0fdd89b51c4a4328b0bb25c03659f726