Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Philippe, Mochirian"'
Autor:
Tommy Lussier, Marie-Ève Waltz, Garrett Freure, Philippe Mochirian, Starr Dostie, Michel Prévost, Yvan Guindon
Publikováno v:
ARKIVOC, Vol 2019, Iss 4, Pp 113-142 (2019)
Externí odkaz:
https://doaj.org/article/7150638c84b94125a6690805daa45d39
Autor:
Monica Bubenik, Pavel Mader, Philippe Mochirian, Fréderic Vallée, Jillian Clark, Jean-François Truchon, Alexander L. Perryman, Victor Pau, Igor Kurinov, Karl E. Zahn, Marie-Eve Leclaire, Robert Papp, Marie-Claude Mathieu, Martine Hamel, Nicole M. Duffy, Claude Godbout, Matias Casas-Selves, Jean-Pierre Falgueyret, Prasamit S. Baruah, Olivier Nicolas, Rino Stocco, Hugo Poirier, Giovanni Martino, Alexanne Bonneau Fortin, Anne Roulston, Amandine Chefson, Stéphane Dorich, Miguel St-Onge, Purvish Patel, Charles Pellerin, Stéphane Ciblat, Thomas Pinter, Francis Barabé, Majida El Bakkouri, Paranjay Parikh, Christian Gervais, Agnel Sfeir, Yael Mamane, Stephen J. Morris, W. Cameron Black, Frank Sicheri, Michel Gallant
Publikováno v:
Journal of Medicinal Chemistry. 65:13198-13215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947c93bf7b6803db8ed4beb935e92af5
https://doi.org/10.1021/acs.jmedchem.2c00998
https://doi.org/10.1021/acs.jmedchem.2c00998
Autor:
Monica, Bubenik, Pavel, Mader, Philippe, Mochirian, Fréderic, Vallée, Jillian, Clark, Jean-François, Truchon, Alexander L, Perryman, Victor, Pau, Igor, Kurinov, Karl E, Zahn, Marie-Eve, Leclaire, Robert, Papp, Marie-Claude, Mathieu, Martine, Hamel, Nicole M, Duffy, Claude, Godbout, Matias, Casas-Selves, Jean-Pierre, Falgueyret, Prasamit S, Baruah, Olivier, Nicolas, Rino, Stocco, Hugo, Poirier, Giovanni, Martino, Alexanne Bonneau, Fortin, Anne, Roulston, Amandine, Chefson, Stéphane, Dorich, Miguel, St-Onge, Purvish, Patel, Charles, Pellerin, Stéphane, Ciblat, Thomas, Pinter, Francis, Barabé, Majida, El Bakkouri, Paranjay, Parikh, Christian, Gervais, Agnel, Sfeir, Yael, Mamane, Stephen J, Morris, W Cameron, Black, Frank, Sicheri, Michel, Gallant
Publikováno v:
Journal of medicinal chemistry. 65(19)
DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead efforts in search of a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::531f44b082fb5f00fe6c2f82d97a48bc
https://pubmed.ncbi.nlm.nih.gov/36126059
https://pubmed.ncbi.nlm.nih.gov/36126059
Autor:
Scott C. Foster, Amarender Manchoju, Starr Dostie, Yvan Guindon, Michel Prévost, Tommy Lussier, Philippe Mochirian, Gang Wang
Publikováno v:
The Journal of Organic Chemistry. 84:16055-16067
The synthesis of novel nucleoside analogues bearing a C3′ all-carbon quaternary center and a C2′-hydroxy substituent is described. The all-carbon stereogenic center was generated through an intramolecular 7-endo attack of a silyl-tethered allyl m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d8477d48eb41c8622d1fa54dbf1109
https://doi.org/10.1021/acs.joc.9b02550
https://doi.org/10.1021/acs.joc.9b02550
Autor:
Michel Prévost, Tommy Lussier, Starr Dostie, Philippe Mochirian, Garrett Freure, Yvan Guindon, Marie-Ève Waltz
Publikováno v:
ARKIVOC, Vol 2019, Iss 4, Pp 113-142 (2019)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f1235c5b87f5a3a04b1156bed3810d
https://doi.org/10.24820/ark.5550190.p010.832
https://doi.org/10.24820/ark.5550190.p010.832
Autor:
Philippe Mochirian, Nicholas Andrella, Michel Prévost, Yvan Guindon, Kashif Tanveer, Starr Dostie, Ariana Rostami, Guillaume Tambutet
Publikováno v:
The Journal of Organic Chemistry. 81:10769-10790
Nucleoside analogues bearing a fluorine in the C2′-position have been synthesized by SN2-like cyclizations of acyclic thioaminal precursors. This strategy provides access to two scaffolds, d-1′,2′-cis-thiofuranosides and d-1′,2′-trans-furan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6999926ade4cb076c7efcf24752c4e9
https://doi.org/10.1021/acs.joc.6b01845
https://doi.org/10.1021/acs.joc.6b01845
Publikováno v:
Tetrahedron. 71:709-726
Reported herein is the total synthesis of zincophorin methyl ester, a polyketide ionophore. Of particular interest is the use of sterically hindered nucleophiles to surmount the unfavorable stereochemical outcome, leading to acetate aldol adducts, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1de97573b3f5fdf1f57903d57b0ed3e
https://doi.org/10.1016/j.tet.2014.11.061
https://doi.org/10.1016/j.tet.2014.11.061
Autor:
Serge I. Gorelsky, Philippe Mochirian, Yvan Guindon, Michel Prévost, Maud Nguyen, François Godin, Frédérick Viens
Publikováno v:
Chemistry - A European Journal. 19:9308-9318
Radical reductions of halogenated precursors bearing a heterocycle exo (α) to the carbon-centered radical proceed with enhanced anti-selectivity, a phenomenon that we termed "exocyclic effect". New experimental data and DFT calculations at the BHand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5428839e5511f6c16f01039f373940a7
https://doi.org/10.1002/chem.201300377
https://doi.org/10.1002/chem.201300377
Autor:
Ioannis Katsoulis, François Godin, Émilie Fiola-Masson, Sabrina Dhambri, Philippe Mochirian, Yvan Guindon
Publikováno v:
Synthesis. 44:474-488
Zincophorin C1-C9 fragment and seven tetrahydropyran analogues were prepared diastereoselectively by sequential iodoetherification and radical hydrogen-transfer reactions. Stereoselective formation of 3,7-trans or 3,7-cis rings was rationalized throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00bc4b0073e1cb0eb9629743c963c106
https://doi.org/10.1055/s-0031-1289661
https://doi.org/10.1055/s-0031-1289661
Autor:
François Godin, Yvan Guindon, Jean-François Brazeau, Ioannis Katsoulis, Isabelle Fontaine, Philippe Mochirian
Publikováno v:
The Journal of Organic Chemistry. 76:7654-7676
The structure-activity study of a bioactive natural product containing polypropionate subunits requires that its stereoisomers also be evaluated. Therefore, a general approach to synthesize these motifs is necessary. We describe herein the synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6df7c102d7dbb9fefa566e87c4843f8
https://doi.org/10.1021/jo2013884
https://doi.org/10.1021/jo2013884