Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Philippe, Marambaud"'
Autor:
Caterina Ivaldo, Mario Passalacqua, Anna Lisa Furfaro, Cristina d’Abramo, Santiago Ruiz, Prodyot K. Chatterjee, Christine N. Metz, Mariapaola Nitti, Philippe Marambaud
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Classical cadherins, including vascular endothelial (VE)-cadherin, are targeted by matrix metalloproteinases (MMPs) and γ-secretase during adherens junction (AJ) disassembly, a mechanism that might have relevance for endothelial cell (EC) i
Externí odkaz:
https://doaj.org/article/8169a08a0cf84a9b98f50732f4d0ad0e
Autor:
John David Eun, Heidy Jimenez, Leslie Adrien, Adam Wolin, Philippe Marambaud, Peter Davies, Jeremy L. Koppel
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-15 (2022)
Abstract Background Exposure to anesthesia in the elderly might increase the risk of dementia. Although the mechanism underlying the association is uncertain, anesthesia has been shown to induce acute tau hyperphosphorylation in preclinical models. W
Externí odkaz:
https://doaj.org/article/d9b69ff470b8434ebfcc2e3bc0c6f3c8
Autor:
Francesca Vitale, Jasmin Ortolan, Bruce T. Volpe, Philippe Marambaud, Luca Giliberto, Cristina d’Abramo
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Abstract With evidence supporting the prion-like spreading of extracellular tau as a mechanism for the initiation and progression of Alzheimer’s disease (AD), immunotherapy has emerged as a potential disease-modifying strategy to target tau. Many s
Externí odkaz:
https://doaj.org/article/329de24503ac492285dfea8bac51979c
Autor:
Archna Sharma, Ezgi Sari, Yongchan Lee, Shivani Patel, Max Brenner, Philippe Marambaud, Ping Wang
Publikováno v:
Molecular Neurobiology. 60:3311-3328
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::570c63ac8192f7e0dc17f1fc4d67be61
https://doi.org/10.1007/s12035-023-03273-3
https://doi.org/10.1007/s12035-023-03273-3
Autor:
Francesca Vitale, Luca Giliberto, Santiago Ruiz, Kristen Steslow, Philippe Marambaud, Cristina d’Abramo
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-13 (2018)
Abstract Tau, the main component of the neurofibrillary tangles (NFTs), is an attractive target for immunotherapy in Alzheimer’s disease (AD) and other tauopathies. MC1/Alz50 are currently the only antibodies targeting a disease-specific conformati
Externí odkaz:
https://doaj.org/article/c2aa948c726941f2a8f9c5e6ab08b8ac
Autor:
Alan D. Workman, Ryan M. Carey, Bei Chen, Cecil J. Saunders, Philippe Marambaud, Claire H. Mitchell, Michael G. Tordoff, Robert J. Lee, Noam A. Cohen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Mechanical stimulation of airway epithelial cells causes apical release of ATP, which increases ciliary beat frequency (CBF) and speeds up mucociliary clearance. The mechanisms responsible for this ATP release are poorly understood. CALHM1,
Externí odkaz:
https://doaj.org/article/c82aa564940a442ca73ece8582700867
Autor:
Valérie Vingtdeux, Haitian Zhao, Pallavi Chandakkar, Christopher M Acker, Peter Davies, Philippe Marambaud
Publikováno v:
Molecular Medicine, Vol 22, Iss 1, Pp 841-849 (2016)
Abstract Strategies aimed at reducing cerebral accumulation of the amyloid-β (Aβ) peptides have therapeutic potential in Alzheimer’s disease (AD). Aβ immunization has proven to be effective at promoting Aβ clearance in animal models, but advers
Externí odkaz:
https://doaj.org/article/84d5ac9f3e794abe8f2434556bbc913a
Publikováno v:
Cells, Vol 9, Iss 3, p 664 (2020)
Calcium homeostasis modulator 1 (CALHM1) is a calcium channel involved in the regulation of cytosolic Ca2+ levels. From a physiological point of view, the open state of CALHM1 depends not only on voltage but also on the extracellular concentration of
Externí odkaz:
https://doaj.org/article/e2cf826af81c4b4c862cf3ee3ac84e87
Publikováno v:
Molecular Neurobiology. 58:3628-3640
Extracellular cold-inducible RNA-binding protein (eCIRP) stimulates microglial inflammation causing neuronal damage during ischemic stroke and is a critical mediator of alcohol-induced cognitive impairment. However, the precise role of eCIRP in media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5379fffb79ff3500016c67f17880552
https://doi.org/10.1007/s12035-021-02368-z
https://doi.org/10.1007/s12035-021-02368-z
Autor:
Jeremy Koppel, Valerie Vingtdeux, Philippe Marambaud, Cristina d’Abramo, Heidy Jimenez, Mark Stauber, Rachel Friedman, Peter Davies
Publikováno v:
Molecular Medicine, Vol 19, Iss 1, Pp 29-36 (2013)
Abstract The endocannabinoid CB2 receptor system has been implicated in the neuropathology of Alzheimer’s disease (AD). In order to investigate the impact of the CB2 receptor system on AD pathology, a colony of mice with a deleted CB2 receptor gene
Externí odkaz:
https://doaj.org/article/0d080a04a6a741f0bc8dc3db1667163b