Staphylococcal sRNA IsrR downregulates methylthiotransferase MiaB under iron-deficient conditions

Autor: Maxime Barrault, Elise Leclair, Etornam Kofi Kumeko, Eric Jacquet, Philippe Bouloc

Publikováno v: Microbiology Spectrum, Vol 12, Iss 10 (2024)

ABSTRACT Staphylococcus aureus is a major contributor to bacterial-associated mortality, owing to its exceptional adaptability across diverse environments. Iron is vital to most organisms but can be toxic in excess. To manage its intracellular iron,

Externí odkaz: https://doaj.org/article/1203e0f65aa640e7b2fd53e917d1a2c5

Staphylococcus aureus pigmentation is not controlled by Hfq

Autor: Wenfeng Liu, Pierre Boudry, Chantal Bohn, Philippe Bouloc

Publikováno v: BMC Research Notes, Vol 13, Iss 1, Pp 1-6 (2020)

Abstract Objective The golden color of Staphylococcus aureus is due to the synthesis of carotenoid pigments. In Gram-negative bacteria, Hfq is a global posttranscriptional regulator, but its function in S. aureus remains obscure. The absence of Hfq i

Externí odkaz: https://doaj.org/article/c821864c2f414e3fb8c3c792f8e36251

csrB Gene Duplication Drives the Evolution of Redundant Regulatory Pathways Controlling Expression of the Major Toxic Secreted Metalloproteases in Vibrio tasmaniensis LGP32

Autor: An Ngoc Nguyen, Elena Disconzi, Guillaume M. Charrière, Delphine Destoumieux-Garzón, Philippe Bouloc, Frédérique Le Roux, Annick Jacq

Publikováno v: mSphere, Vol 3, Iss 6 (2018)

ABSTRACT CsrBs are bacterial highly conserved and multiple-copy noncoding small RNAs (sRNAs) that play major roles in cell physiology and virulence. In the Vibrio genus, they are known to be regulated by the two-component system VarS/VarA. They modul

Externí odkaz: https://doaj.org/article/b2c3960f70c0464f9390c57501e65a6c

Assessment of Bona Fide sRNAs in Staphylococcus aureus

Autor: Wenfeng Liu, Tatiana Rochat, Claire Toffano-Nioche, Thao Nguyen Le Lam, Philippe Bouloc, Claire Morvan

Publikováno v: Frontiers in Microbiology, Vol 9 (2018)

Bacterial regulatory RNAs have been extensively studied for over a decade, and are progressively being integrated into the complex genetic regulatory network. Transcriptomic arrays, recent deep-sequencing data and bioinformatics suggest that bacteria

Externí odkaz: https://doaj.org/article/e0168d445731441e82188cc14aa4e902

Pervasive transcription enhances the accessibility of H-NS-silenced promoters and generates bistability in Salmonella virulence gene expression

Autor: Nara Figueroa-Bossi, María Antonia Sánchez-Romero, Patricia Kerboriou, Delphine Naquin, Clara Mendes, Philippe Bouloc, Josep Casadesús, Lionello Bossi

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2022, 119, pp.e2203011119. ⟨10.1073/pnas.2203011119⟩

In Escherichia coli and Salmonella, many genes silenced by the nucleoid structuring protein H-NS are activated upon inhibiting Rho-dependent transcription termination. This response is poorly understood and difficult to reconcile with the view that H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5f818aec512040880ed2bf206c4e68
https://doi.org/10.1101/2022.04.26.489344