Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Philippe, Bergeron"'
Autor:
Marc Kschonsak, Christine C Jao, Christopher P Arthur, Alexis L Rohou, Philippe Bergeron, Daniel F Ortwine, Steven J McKerrall, David H Hackos, Lunbin Deng, Jun Chen, Tianbo Li, Peter S Dragovich, Matthew Volgraf, Matthew R Wright, Jian Payandeh, Claudio Ciferri, John C Tellis
Publikováno v:
eLife, Vol 12 (2023)
The voltage-gated sodium (NaV) channel NaV1.7 has been identified as a potential novel analgesic target due to its involvement in human pain syndromes. However, clinically available NaV channel-blocking drugs are not selective among the nine NaV chan
Externí odkaz:
https://doaj.org/article/1b1793fee7d349608601029e46d0c8cd
Autor:
Christine C Jao, Marc Kschonsak, Christopher P Arthur, Alexis L Rohou, Philippe Bergeron, Daniel F Ortwine, Steven J McKerrall, David H Hackos, Lunbin Deng, Jun Chen, Tianbo Li, Peter S Dragovich, Matthew Volgraf, Matthew R Wright, Jian Payandeh, Claudio Ciferri, John C Tellis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd282fdd94d6f54f454fbf1d90a6ee32
https://doi.org/10.7554/elife.84151.sa2
https://doi.org/10.7554/elife.84151.sa2
Autor:
Evgeny Kanshin, Louis-Philippe Bergeron-Sandoval, S. Sinan Isik, Pierre Thibault, Stephen W. Michnick
Publikováno v:
Cell Reports, Vol 10, Iss 7, Pp 1202-1214 (2015)
If specific and functional kinase- or phosphatase-substrate interactions are optimized for binding compared to promiscuous interactions, then changes in phosphorylation should occur faster on functional versus promiscuous substrates. To test this hyp
Externí odkaz:
https://doaj.org/article/015efd6b1cf7412ab2baea3460b8021a
Autor:
Marc Kschonsak, Christine C. Jao, Christopher P. Arthur, Alexis L. Rohou, Philippe Bergeron, Daniel Ortwine, Steven J. McKerrall, David H. Hackos, Lunbin Deng, Jun Chen, Peter S. Dragovich, Matthew Volgraf, Matthew R. Wright, Jian Payandeh, Claudio Ciferri, John C. Tellis
The voltage-gated sodium (NaV) channel NaV1.7 has been identified as a potential novel pain target due to its striking human genetics. However, clinically available drugs (e.g. lidocaine, carbamazepine, etc.) are not selective among the nine NaV chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cb81783c5e491a22f8ca88176067e13
https://doi.org/10.1101/2022.11.10.515983
https://doi.org/10.1101/2022.11.10.515983
Autor:
Sultan Chowdhury, Christoph Martin Dehnhardt, Tao Sheng, Clint Young, Rainbow Kwan, Michael Scott Wilson, Jun Chen, Matthew Waldbrook, Dinah Misner, C. Lee Robinette, Rebecca M. Reese, Elaine Chang, Henry Verschoof, Tanja S. Zabka, Girish Bankar, Philippe Bergeron, Luis Sojo, Karen Nelkenbrecher, Daniel P. Sutherlin, Amy Kim, Ivan William Hemeon, Andrea Lindgren, Jae H. Chang, Alla Yurevna Zenova, Shaoyi Sun, Jonathan Maher, Shannon D. Shields, Jun Li, Daniel F. Ortwine, David H. Hackos, Zhiwei Xie, Thilo Focken, Charles J. Cohen, Richard T. Dean, Shannon Decker, Janette Mezeyova, Kuldip Khakh, Antonio G. DiPasquale, Chien-An Chen, Andrew D. White, Brian Safina, Jodie Pang, Qi Jia, Sophia Lin, Jean-Christophe Andrez, J. P. Johnson, Steven J. McKerrall
Publikováno v:
Journal of Medicinal Chemistry. 64:2953-2966
Nav1.7 is an extensively investigated target for pain with a strong genetic link in humans, yet in spite of this effort, it remains challenging to identify efficacious, selective, and safe inhibitors. Here, we disclose the discovery and preclinical p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a8a9431d81bf8ca2eed0fbbfbb36905
https://doi.org/10.1021/acs.jmedchem.1c00049
https://doi.org/10.1021/acs.jmedchem.1c00049
Autor:
Louis-Philippe Bergeron-Sandoval, Sandeep Kumar, Hossein Khadivi Heris, Catherine L. A. Chang, Caitlin E. Cornell, Sarah L. Keller, Paul François, Adam G. Hendricks, Allen J. Ehrlicher, Rohit V. Pappu, Stephen W. Michnick
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The uptake of molecules into cells, known as endocytosis, requires membrane invagination and the formation of vesicles. A version of endocytosis that is independent of actin polymerization is aided by the assembly of membraneless biomole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f08cbe652b11389dbab7a42a6a351e
https://pubmed.ncbi.nlm.nih.gov/34887356
https://pubmed.ncbi.nlm.nih.gov/34887356
Autor:
Felix Tettenborn, Philippe Bergeron
Publikováno v:
WASSERWIRTSCHAFT. 109:51-54
Um die finanzielle Tragfähigkeit der Umsetzung eines verbesserten Kleinwasserkraftanlagendesigns hinsichtlich des chinesischen Elektrizitätsmarkts abzuschätzen zu können, wurde ein einfach umzusetzender Bewertungsansatz erstellt. Grundlage für d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1071708b959148316b1353e36faad9
https://doi.org/10.1007/s35147-019-0099-2
https://doi.org/10.1007/s35147-019-0099-2
Autor:
Jodie Pang, Lunbin Deng, Girish Bankar, Jun Chen, Sultan Chowdhury, William R Proctor, Philippe Bergeron, Jennifer Vogt, Daniel F. Ortwine, Daniel P. Sutherlin, Jian Payandeh, Lilia Schumann, Shannon D. Shields, Christoph Martin Dehnhardt, Jae H. Chang, David H. Hackos, Elisa Ballini, Teresa Nguyen, Pengfei Ji, Glauco Tarozzo, Charles J. Cohen, Antonio G. DiPasquale, Kwong Wah Lai, Jonathan Maher, Kuldip Khakh, Steven J. McKerrall, Tania Chernov-Rogan, Wenfeng Liu, Brian Safina, Sophia Lin, Abid Hasan, J. P. Johnson
Publikováno v:
Journal of Medicinal Chemistry. 62:4091-4109
Using structure- and ligand-based design principles, a novel series of piperidyl chromane arylsulfonamide Nav1.7 inhibitors was discovered. Early optimization focused on improvement of potency through refinement of the low energy ligand conformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::824349f727cab11e6b607d5268a59967
https://doi.org/10.1021/acs.jmedchem.9b00141
https://doi.org/10.1021/acs.jmedchem.9b00141
Autor:
Brian S, Safina, Steven J, McKerrall, Shaoyi, Sun, Chien-An, Chen, Sultan, Chowdhury, Qi, Jia, Jun, Li, Alla Y, Zenova, Jean-Christophe, Andrez, Girish, Bankar, Philippe, Bergeron, Jae H, Chang, Elaine, Chang, Jun, Chen, Richard, Dean, Shannon M, Decker, Antonio, DiPasquale, Thilo, Focken, Ivan, Hemeon, Kuldip, Khakh, Amy, Kim, Rainbow, Kwan, Andrea, Lindgren, Sophia, Lin, Jonathan, Maher, Janette, Mezeyova, Dinah, Misner, Karen, Nelkenbrecher, Jodie, Pang, Rebecca, Reese, Shannon D, Shields, Luis, Sojo, Tao, Sheng, Henry, Verschoof, Matthew, Waldbrook, Michael S, Wilson, Zhiwei, Xie, Clint, Young, Tanja S, Zabka, David H, Hackos, Daniel F, Ortwine, Andrew D, White, J P, Johnson, C Lee, Robinette, Christoph M, Dehnhardt, Charles J, Cohen, Daniel P, Sutherlin
Publikováno v:
Journal of medicinal chemistry. 64(6)
Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d744b2a5894fa87236be1caf92c75b8b
https://pubmed.ncbi.nlm.nih.gov/33682420
https://pubmed.ncbi.nlm.nih.gov/33682420
Autor:
Jean-Philippe Bergeron
Septième livre de Jean-Philippe Bergeron (Grand prix Québecor du FIPTR 2019), genèse, berceau, dessin de la lune explore « la bifurcation existentielle » que la naissance d'un enfant peut opérer en nous ; ce que le poète nomme « l'effondrem