Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Philippa Pettingill"'
Autor:
Greg A. Weir, Philippa Pettingill, Yukyee Wu, Galbha Duggal, Andrei-Sorin Ilie, Colin J. Akerman, M. Zameel Cader
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Two-pore domain K+ (K2P) channels generate K+ leak current, which serves a vital role in controlling and modulating neuronal excitability. This diverse family of K+ channels exhibit distinct expression and function across neuronal tissues. TWIK-relat
Externí odkaz:
https://doaj.org/article/bb3a76adef4b40cd8d24e45cf3894402
Publikováno v:
Advances in Clinical Neuroscience & Rehabilitation, Vol , Iss (2016)
The last 15 years has seen the discovery of treatable antibody-mediated CNS diseases. The accurate detection of specific antibodies helps support patient diagnosis, treatment and predict prognosis. Here we discuss some of the limitations of different
Externí odkaz:
https://doaj.org/article/bf709de3c1164a0c87fb7fc38b865329
Autor:
Thashi Chang, Harry Alexopoulos, Philippa Pettingill, Mary McMenamin, Robert Deacon, Ferenc Erdelyi, Gabor Szabó, Camilla J. Buckley, Angela Vincent
Publikováno v:
PLoS ONE, Vol 8, Iss 10 (2013)
Externí odkaz:
https://doaj.org/article/8643e667cfd34ba3bc4c0e636b8e452a
Autor:
Thashi Chang, Harry Alexopoulos, Philippa Pettingill, Mary McMenamin, Robert Deacon, Ferenc Erdelyi, Gabor Szabó, Camilla J Buckley, Angela Vincent
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72921 (2013)
Stiff person syndrome (SPS) is a highly-disabling neurological disorder of the CNS characterized by progressive muscular rigidity and spasms. In approximately 60-80% of patients there are autoantibodies to glutamic acid decarboxylase (GAD), the enzym
Externí odkaz:
https://doaj.org/article/9b435ec0dcde456580f3870ccfd06a64
Autor:
Larisa M. Haupt, Satyan Chintawar, Jonathan Cheung, Grace Flower, M. Zameel Cader, Philippa Pettingill, Greg A. Weir, Tatjana Lalic, Kanisa Arunasalam, Yukyee Wu, Sally A. Cowley, Tina Wei, Lyn R. Griffiths, Galbha Duggal, Andrew R. Bassett, Elizabeth Couper, Adam E. Handel
Publikováno v:
Brain
The two-pore potassium channel TRESK is a potential drug target in pain and migraine. Pettingill et al. show that the F139WfsX2 mutation causes TRESK loss of function and hyperexcitability in nociceptors derived from iPSCs of patients with migraine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d91dc27ec893dbb7d51f75d4d52abd
http://europepmc.org/articles/PMC6906598
http://europepmc.org/articles/PMC6906598
Autor:
Colin J. Akerman, Galbha Duggal, Philippa Pettingill, Yukyee Wu, Andrei-Sorin Ilie, Greg A. Weir, M. Zameel Cader
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience
Two-pore domain K+ (K2P) channels generate K+ leak current, which serves a vital role in controlling and modulating neuronal excitability. This diverse family of K+ channels exhibit distinct expression and function across neuronal tissues. TWIK-relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b2242be37351cfa95688852d023f27
https://www.frontiersin.org/article/10.3389/fnmol.2019.00170/full
https://www.frontiersin.org/article/10.3389/fnmol.2019.00170/full
Autor:
Angela, Vincent, Philippa, Pettingill, Rosie, Pettingill, Bethan, Lang, Ron, Birch, Patrick, Waters, Sarosh R, Irani, Camilla, Buckley, Osamu, Watanabe, Kimiyoshi, Arimura, Matthew C, Kiernan
Publikováno v:
JAMA Neurology
Key Points Questions Which specific targets of voltage-gated potassium channel–complex antibodies are found in acquired neuromyotonia, and are these antibodies associated with additional clinical features of tumors, pain, or autonomic or central di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6de68734fef4dad15925a6d38ecf2a5a
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Rosie Pettingill, Sarosh R. Irani, Bethan Lang, Patrick Waters, David Beeson, Anu Jacob, Angela Vincent, Holger B. Kramer, Susan Maxwell, Anjan Nibber, Camilla Buckley, Andrea Malaspina, Philippa Pettingill, Jan Adriaan Coebergh
Publikováno v:
Neurology
Objective: To search for antibodies against neuronal cell surface proteins. Methods: Using immunoprecipitation from neuronal cultures and tandem mass spectrometry, we identified antibodies against the α1 subunit of the γ-aminobutyric acid A recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68172b29d57d3703923d2e34ddf415c
https://doi.org/10.1212/wnl.0000000000001326
https://doi.org/10.1212/wnl.0000000000001326
Autor:
Dimitri M. Kullmann, Angela Vincent, Anjan Nibber, Bethan Lang, Philippa Pettingill, Edward O. Mann, Sarosh R. Irani, Patrick Waters
Publikováno v:
Epilepsia Open
Summary GABAB receptor (GABABR) autoantibodies have been detected in the serum of immunotherapy‐responsive patients with autoimmune encephalitis. This study aimed to investigate the effect of immunoglobulin G (IgG) from a patient with GABABR antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3add1747da3ea70c7ad328cf7df1e548
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Patrick Waters, Ming K. Lim, Yael Hacohen, Pascale Chrétien, Jean-Pierre Lin, Philippa Pettingill, Angela Vincent, Marc Tardieu, Kumaran Deiva, Esse Menson, Ata Siddiqui
Publikováno v:
Movement Disorders. 29:90-96
Herpes simplex virus encephalitis (HSVE) is a devastating condition that relapses, often with a chorea in children, despite adequate antiviral treatment. At relapse, evidence of viral replication is frequently absent, suggesting that the relapse may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2df75d0b11701726df9fbf8a9c07295b
https://doi.org/10.1002/mds.25626
https://doi.org/10.1002/mds.25626