Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C

Autor: Shoeib Moradi, Sanda Stankovic, Geraldine M. O’Connor, Phillip Pymm, Bruce J. MacLachlan, Camilla Faoro, Christelle Retière, Lucy C. Sullivan, Philippa M. Saunders, Jacqueline Widjaja, Shea Cox-Livingstone, Jamie Rossjohn, Andrew G. Brooks, Julian P. Vivian

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

KIR2DL2 and KIR2DL3 are two inhibitory members of the killer-cell immunoglobulin-like receptors (KIR) family that share a common HLA-I preference in binding HLA from the C1 group. However, it is still unclear to what extent binding and function is eq

Externí odkaz: https://doaj.org/article/2e2f5009dd934a8381838529885caa65

Host Cell Restriction Factors that Limit Influenza A Infection

Autor: Fernando Villalón-Letelier, Andrew G. Brooks, Philippa M. Saunders, Sarah L. Londrigan, Patrick C. Reading

Publikováno v: Viruses, Vol 9, Iss 12, p 376 (2017)

Viral infection of different cell types induces a unique spectrum of host defence genes, including interferon-stimulated genes (ISGs) and genes encoding other proteins with antiviral potential. Although hundreds of ISGs have been described, the vast

Externí odkaz: https://doaj.org/article/1aa446913a1e4b119cc77e557a633791

Natural killer cell receptors regulate responses of HLA-E-restricted T cells

Autor: Abbie Kanagarajah, Andrew G. Brooks, Zhangying Cai, Jie Lin, Karl J. Malmberg, Lucy C. Sullivan, Christopher M. Harpur, Thi H. O. Nguyen, Marios Koutsakos, Jerome Samir, Jacqueline M.L. Widjaja, Fabio Luciani, Lorenzo Moretta, James A. Gray, Maria Cristina Mingari, Gabriella Pietra, Philippa M. Saunders, Katherine Kedzierska, Sanda Stankovic, Glen P. Westall

Human cytomegalovirus (CMV) infection can stimulate robust human leukocyte antigen (HLA)-E-restricted CD8+ T cell responses. These T cells recognize a peptide from UL40, which differs by as little as a single methyl group from self-peptides that also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba60ed4611e0295de767750645eb168
http://hdl.handle.net/11567/1063756

The Role of the HLA Class I α2 Helix in Determining Ligand Hierarchy for the Killer Cell Ig-like Receptor 3DL1

Autor: Bruce J. MacLachlan, Jamie Rossjohn, Shu Cheng Wong, Clare V. Oates, Jacqueline M.L. Widjaja, Philippa M. Saunders, Julian P. Vivian, Andrew G. Brooks

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 206(4)

HLA class I molecules that represent ligands for the inhibitory killer cell Ig-like receptor (KIR) 3DL1 found on NK cells are categorically defined as those HLA-A and HLA-B allotypes containing the Bw4 motif, yet KIR3DL1 demonstrates hierarchical rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d08ebc7e56f8d37b1248ec285c4e63a
https://pubmed.ncbi.nlm.nih.gov/33441440

Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C

Autor: Camilla Faoro, Sanda Stankovic, Shea Cox-Livingstone, Christelle Retière, Jacqueline M.L. Widjaja, Phillip Pymm, Geraldine Martina O'Connor, Julian P. Vivian, Jamie Rossjohn, Lucy C. Sullivan, Philippa M. Saunders, Andrew G. Brooks, Bruce J. MacLachlan, Shoeib Moradi

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.2173. ⟨10.1038/s41467-021-22359-x⟩
Nature Communications, 2021, 12 (1), pp.2173. ⟨10.1038/s41467-021-22359-x⟩
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

The closely related inhibitory killer-cell immunoglobulin-like receptors (KIR), KIR2DL2 and KIR2DL3, regulate the activation of natural killer cells (NK) by interacting with the human leukocyte antigen-C1 (HLA-C1) group of molecules. KIR2DL2, KIR2DL3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7120c75213254c01c44e08b06619ef09
https://pubmed.ncbi.nlm.nih.gov/33846289