Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Philippa J. L. Simpson"'
Autor:
Joanne T.M. Tan, Laura Lecce, Yuen Ting Lam, Anthony C Keech, Jun Yuan, Alicia J. Jenkins, Emma L. Solly, Martin K.C. Ng, Kushwin Rajamani, Christina A. Bursill, Philippa J. L. Simpson, E. King
Publikováno v:
Diabetes. 68:1040-1053
Fenofibrate, a peroxisome proliferator–activated receptor α (PPARα) agonist, reduces lower limb amputations in patients with type 2 diabetes. The mechanism is, however, unknown. In this study, we demonstrate that fenofibrate markedly attenuates d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c844616ee903136bb76fa3abf8ec1c0a
https://doi.org/10.2337/db17-0926
https://doi.org/10.2337/db17-0926
Autor:
Kim H Chan, Philippa J L Simpson, Andy S Yong, Louise L Dunn, Chirapan Chawantanpipat, Chijen Hsu, Young Yu, Anthony C Keech, David S Celermajer, Martin K C Ng
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93980 (2014)
BACKGROUND: Endothelial progenitor cells (EPCs) are implicated in protection against vascular disease. However, studies using angiography alone have reported conflicting results when relating EPCs to epicardial coronary artery disease (CAD) severity.
Externí odkaz:
https://doaj.org/article/f68aff4e87da4a0f9176a02b3aa5c90e
Autor:
Kim H. Chan, Louise L. Dunn, Andy S.C. Yong, Philippa J. L. Simpson, Laura Lecce, Martin K.C. Ng, Yuen Ting Lam, Daniel P Sieveking, C. Hsu, David S. Celermajer, Young Yu, Jun Yuan, Steven G. Wise, Renee Chow
Publikováno v:
Endocrinology. 161(5)
Endothelial progenitor cells (EPCs) play a key role in neovascularization and have been linked to improved cardiovascular outcomes. Although there is a well-established inverse relationship between androgen levels and cardiovascular mortality in men,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac1a2bddfc46236ef8dd1c72cd1494c
https://pubmed.ncbi.nlm.nih.gov/32157309
https://pubmed.ncbi.nlm.nih.gov/32157309
Autor:
Laura A. Lindsay, David J. Handelsman, Yuen Ting Lam, Sui Ching Yuen, Martin K.C. Ng, Laura Lecce, Philippa J. L. Simpson
Publikováno v:
Molecular Endocrinology. 28:1487-1501
There is a progressive impairment of vascular repair mechanisms with advancing age concomitant with a steady decline in circulating androgen levels in men. Emerging evidence indicates androgens regulate angiogenesis; however, little research has focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7406965945d717766f1b9a41a341b7f
https://doi.org/10.1210/me.2013-1405
https://doi.org/10.1210/me.2013-1405
Autor:
Andrew Buckle, David S. Celermajer, Martin K.C. Ng, Daniel P Sieveking, Renee Chow, Nadina Stadler, Gloria S. C. Yuen, Laura Lecce, P. Lim, Louise L. Dunn, Zoe E. Clayton, Hamish G. C. Prosser, Michael J. Davies, Christina A. Bursill, Shisan Bao, Philippa J. L. Simpson, Yuen Ting Lam, Laura Z. Vanags, Roland Stocker, John P. Cooke
Publikováno v:
Diabetes
Impaired angiogenesis in ischemic tissue is a hallmark of diabetes. Thioredoxin-interacting protein (TXNIP) is an exquisitely glucose-sensitive gene that is overexpressed in diabetes. As TXNIP modulates the activity of the key angiogenic cytokine vas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4327d4f1413baff63a605c7edb2833a3
https://doi.org/10.2337/db13-0417
https://doi.org/10.2337/db13-0417
Publikováno v:
International Journal of Cardiology. 168:2042-2048
Obstructive sleep apnoea (OSA) is characterised by reoccurring apnoeas and hypopneas, causing repetitive hypoxia and reoxygenation, and is associated with endothelial dysfunction and reduced levels of circulating progenitor cells (CPCs). The potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39dec67458bb1da409addaabff7e7def
https://doi.org/10.1016/j.ijcard.2013.01.166
https://doi.org/10.1016/j.ijcard.2013.01.166
Autor:
Andy S.C. Yong, Philippa J. L. Simpson, Kim H. Chan, Martin K.C. Ng, Louise L. Dunn, Ashkan Javadzadegan, A. Snir, C. Hsu
Publikováno v:
Heart, Lung and Circulation. 26:S99
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::571de9a8a0cf8a4ad1f7c403790fb567
https://doi.org/10.1016/j.hlc.2017.06.128
https://doi.org/10.1016/j.hlc.2017.06.128
Publikováno v:
Heart, Lung and Circulation. 26:S64
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4717782dde38d72bd06e620385cfdc9
https://doi.org/10.1016/j.hlc.2017.06.050
https://doi.org/10.1016/j.hlc.2017.06.050
Autor:
Laura Lecce, Yuen Ting Lam, Zoe E. Clayton, Richard H. Karas, Philippa J. L. Simpson, Martin K.C. Ng
Publikováno v:
Heart, Lung and Circulation. 25:S10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6ef4668629670383c4adb7ffcf9d175
https://doi.org/10.1016/j.hlc.2016.06.022
https://doi.org/10.1016/j.hlc.2016.06.022
Autor:
Joseph Levitt, Richard Liu, Martin K.C. Ng, Laura Lecce, P. Lim, Christina A. Bursill, Philippa J. L. Simpson, Louise L. Dunn
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 32
Introduction: Endothelial progenitor cell (EPC) participation in neovascularization of ischemic tissue is impaired in diabetes mellitus. Thioredoxin interacting protein (TXNIP) is strongly induced by glucose. TXNIP is overexpressed in tissues of diab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5d4d211d55318d84295b72a15cc5c38
https://doi.org/10.1161/atvb.32.suppl_1.a388
https://doi.org/10.1161/atvb.32.suppl_1.a388