Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Philippa Hillyer"'
Autor:
Cyril Le Nouën, Philippa Hillyer, Christine C Winter, Thomas McCarty, Ronald L Rabin, Peter L Collins, Ursula J Buchholz
Publikováno v:
PLoS Pathogens, Vol 7, Iss 6, p e1002105 (2011)
Human respiratory syncytial virus (HRSV) and, to a lesser extent, human metapneumovirus (HMPV) and human parainfluenza virus type 3 (HPIV3), can re-infect symptomatically throughout life without significant antigenic change, suggestive of incomplete
Externí odkaz:
https://doaj.org/article/9e596a2b726743cf82a24388c142a4c5
Autor:
Shirin Munir, Philippa Hillyer, Cyril Le Nouën, Ursula J Buchholz, Ronald L Rabin, Peter L Collins, Alexander Bukreyev
Publikováno v:
PLoS Pathogens, Vol 7, Iss 4, p e1001336 (2011)
We recently demonstrated that the respiratory syncytial virus (RSV) NS1 protein, an antagonist of host type I interferon (IFN-I) production and signaling, has a suppressive effect on the maturation of human dendritic cells (DC) that was only partly d
Externí odkaz:
https://doaj.org/article/b3f029ad50a449eaafaa4bb767fa16ac
Autor:
Cyril Le Nouën, Philippa Hillyer, Shirin Munir, Christine C Winter, Thomas McCarty, Alexander Bukreyev, Peter L Collins, Ronald L Rabin, Ursula J Buchholz
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15017 (2010)
Human respiratory syncytial virus (HRSV), and to a lesser extent human metapneumovirus (HMPV) and human parainfluenza virus type 3 (HPIV3), re-infect symptomatically throughout life without antigenic change, suggestive of incomplete immunity. One cau
Externí odkaz:
https://doaj.org/article/5d95621bd1ff4b96867c6579fb0a378f
Autor:
Craig Martens, Eric A. Levenson, Ronald L. Rabin, Cyril Le Nouën, Peter L. Collins, Ursula J. Buchholz, Philippa Hillyer
Publikováno v:
Journal of Virology. 93
Respiratory syncytial virus (RSV) infects and causes disease in infants and reinfects with reduced disease throughout life without significant antigenic change. In contrast, reinfection by influenza A virus (IAV) largely requires antigenic change. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e207ba00fc742c6920d12c336de7d4f8
https://doi.org/10.1128/jvi.01216-19
https://doi.org/10.1128/jvi.01216-19
Publikováno v:
The Journal of Immunology. 206:20.33-20.33
House dust mites (HDM) are a predominant causative agent of airway hypersensitivity and asthma. The HDM group 1 allergens include Der p 1, a cysteine protease that contributes to sensitization and symptom exacerbation. Respiratory syncytial virus (RS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c11b1b57d66c67204105611e6ab3c39
https://doi.org/10.4049/jimmunol.206.supp.20.33
https://doi.org/10.4049/jimmunol.206.supp.20.33
Autor:
Faruk Sheikh, Ursula J. Buchholz, Mina Krenz, Rachel Shepard, Lei Huang, Megan Uehling, Philippa Hillyer, Lihan Yan, Debasis Panda, Ronald L. Rabin, Kalyn R. Thayer, Cindy Luongo, Peter L. Collins, Raymond P. Donnelly
Publikováno v:
Journal of Virology. 92
Respiratory syncytial virus (RSV) infects small foci of respiratory epithelial cells via infected droplets. Infection induces expression of type I and III interferons (IFNs) and proinflammatory cytokines, the balance of which may restrict viral repli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae39600b9459a24c1b1b0b4688b4f84b
https://doi.org/10.1128/jvi.02202-17
https://doi.org/10.1128/jvi.02202-17
Autor:
Ronald L. Rabin, Peter L. Collins, Cyril Le Nouën, Christine C. Winter, Linda G. Brock, Philippa Hillyer, Ursula J. Buchholz
Publikováno v:
Journal of Virology. 88:6453-6469
Human metapneumovirus (HMPV) is a major etiologic agent of respiratory disease worldwide. HMPV reinfections are common in healthy adults and children, suggesting that the protective immune response to HMPV is incomplete and short-lived. We used gene-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2799717c5ba7f59c28a4ac56991d633
https://doi.org/10.1128/jvi.03261-13
https://doi.org/10.1128/jvi.03261-13
Autor:
Jie Liu, Barney S. Graham, Teresa R. Johnson, Nataly Raviv, Ronald L. Rabin, Danielle Dougherty, Doria M. Gold, Philippa Hillyer
Publikováno v:
European Journal of Immunology. 43:3197-3208
Human type I interferons (IFNs) include IFN-β and 12 subtypes of IFN-α. During viral infection, infiltrating memory CD4+ T cells are exposed to IFNs, but their impact on memory T-cell function is poorly understood. To address this, we pretreated PB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79506ecd5f9932b4a1699ce883a055a4
https://doi.org/10.1002/eji.201243288
https://doi.org/10.1002/eji.201243288
Autor:
Peter L. Collins, Cindy Luongo, Ursula J. Buchholz, Ronald G. Jubin, Maria B. dos Santos, Cyril Le Nouën, Lynnsie M. Schramm, Philippa Hillyer, Lei Huang, Ronald L. Rabin, Lihan Yan, Aaron Chen, Viraj P. Mane, Rachel Shepard
Publikováno v:
Virology. 504
Whether respiratory syncytial virus (RSV) induces severe infantile pulmonary disease may depend on viral strain and expression of types I and III interferons (IFNs). These IFNs impact disease severity by inducing expression of many anti-viral IFN-sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4221082759b2ddff3e414212d142393
https://pubmed.ncbi.nlm.nih.gov/28157546
https://pubmed.ncbi.nlm.nih.gov/28157546
Autor:
Srikant Bykadi, Philippa Hillyer, Ronald L. Rabin, Viraj P. Mane, Daniela Verthelyi, Ronald G Jubin, Maria B Navarro, Lynnsie M. Schramm, Aaron Chen, Kevin D. Kirschman, Zeng Zhao, Montserrat Puig
Publikováno v:
Immunology and Cell Biology
Recent genome-wide association studies suggest distinct roles for 12 human interferon-alpha (IFN-α) and 3 IFN-λ subtypes that may be elucidated by defining the expression patterns of these sets of genes. To overcome the impediment of high homology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae698d6e22e3d61f2c318853d7c959bf
https://doi.org/10.1038/icb.2011.109
https://doi.org/10.1038/icb.2011.109