Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Philippa H, Stokes"'
Autor:
Soumya Joseph, Ann H Kwan, Philippa H Stokes, Joel P Mackay, Liza Cubeddu, Jacqueline M Matthews
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109108 (2014)
LIM-domain only protein 4 (LMO4) is a widely expressed protein with important roles in embryonic development and breast cancer. It has been reported to bind many partners, including the transcription factor Deformed epidermal autoregulatory factor-1
Externí odkaz:
https://doaj.org/article/093749faa0124e2ea08beea63a3356a5
Autor:
David T Yeung, Peter J. Brautigan, Chan Eng Chong, Young Koung Lee, Milena Babic, Parvathy Venugopal, Hamish S. Scott, Jacqueline M. Matthews, Grant A Engler, Christopher N. Hahn, Manuela Klingler-Hoffmann, Philippa H. Stokes, Richard J D'Andrea, Steven W. Lane, Anna L. Brown
Publikováno v:
Leukemia
Heterozygous GATA2 mutations underlie an array of complex hematopoietic and lymphatic diseases. Analysis of the literature reporting three recurrent GATA2 germline (g) mutations (gT354M, gR396Q and gR398W) revealed different phenotype tendencies. Alt
Autor:
Tanya Estephan, Ana P. G. Silva, Philippa H. Stokes, Neil O. Robertson, J. Mitchell Guss, Jill Trewhella, Jacqueline M. Matthews
Publikováno v:
Proteins. 87(5)
Tandem beta zippers are modular complexes formed between repeated linear motifs and tandemly arrayed domains of partner proteins in which β-strands form upon binding. Studies of such complexes, formed by LIM domain proteins and linear motifs in thei
Autor:
Natasha L. Harvey, Jan Kazenwadel, Chan-Eng Chong, Genevieve A. Secker, Jacqueline M. Matthews, David M. Lawrence, Kelly L. Betterman, Sébastien Tabruyn, Cansaran Saygili Demir, Philippa H. Stokes, Yan Agalarov, Naoyuki Miura, Young Koung Lee, Tatiana V. Petrova, Drew L. Sutton, Marjo Salminen, Hamish S. Scott, Christopher N. Hahn
Publikováno v:
The Journal of clinical investigation
Journal of Clinical Investigation, vol. 125, no. 8, pp. 2979-2994
Journal of Clinical Investigation, vol. 125, no. 8, pp. 2979-2994
Heterozygous germline mutations in the zinc finger transcription factor GATA2 have recently been shown to underlie a range of clinical phenotypes, including Emberger syndrome, a disorder characterized by lymphedema and predisposition to myelodysplast
Publikováno v:
Biomolecular NMR Assignments. 6:31-34
LMO4 is a broadly expressed LIM-only protein that is involved in neural tube development and implicated in breast cancer. Here we report backbone and side chain NMR assignments for an engineered intramolecular complex of the N-terminal LIM domain fro
Publikováno v:
Biochemical and Biophysical Research Communications. 354:197-202
CtIP is a tumor suppressor that interacts with Retinoblastoma protein (Rb) to regulate the G1/S-phase transition of the cell cycle. Despite its large size (897 residues) CtIP has few known structured regions. Rather it contains several linear motifs
Autor:
Philippa H. Stokes, Merridee A. Wouters, Lyle E. Carrington, Robert M. Graham, Jacqueline M. Matthews, Ahsan Husain, Gillian E. Begg, Laszlo Lorand, Siiri E. Iismaa
Publikováno v:
Proceedings of the National Academy of Sciences. 103:19683-19688
Allosteric regulation is a fundamental mechanism of biological control. Here, we investigated the allosteric mechanism by which GTP inhibits cross-linking activity of transglutaminase 2 (TG2), a multifunctional protein, with postulated roles in recep
Autor:
Robert M. Graham, Philippa H. Stokes, Sara R. Holman, Jacqueline M. Matthews, Siiri E. Iismaa, Gillian E. Begg
Publikováno v:
Journal of Biological Chemistry. 281:12603-12609
Transglutaminase type 2 (TG2; also known as G(h)) is a multifunctional protein involved in diverse cellular processes. It has two well characterized enzyme activities: receptor-stimulated signaling that requires GTP binding and calcium-activated tran
Autor:
Saad S M, Alqarni, Andal, Murthy, Wei, Zhang, Marcin R, Przewloka, Ana P G, Silva, Aleksandra A, Watson, Sara, Lejon, Xue Y, Pei, Arne H, Smits, Susan L, Kloet, Hongxin, Wang, Nicholas E, Shepherd, Philippa H, Stokes, Gerd A, Blobel, Michiel, Vermeulen, David M, Glover, Joel P, Mackay, Ernest D, Laue
Publikováno v:
The Journal of Biological Chemistry
Background: The NuRD complex controls gene expression through altering chromatin structure. Results: The MTA1-RbAp48 structure shows how the RbAp46/p48 histone chaperones are recruited to NuRD. Conclusion: The MTA subunits act as scaffolds for NuRD c
Autor:
Ann H. Kwan, Soumya Joseph, Philippa H. Stokes, Liza Cubeddu, Jacqueline M. Matthews, Joel P. Mackay
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109108 (2014)
PLoS ONE
PLoS ONE
LIM-domain only protein 4 (LMO4) is a widely expressed protein with important roles in embryonic development and breast cancer. It has been reported to bind many partners, including the transcription factor Deformed epidermal autoregulatory factor-1