Neuronal let-7b-5p acts through the Hippo-YAP pathway in neonatal encephalopathy

Autor: Vennila Ponnusamy, Richard T. H. Ip, Moumin A. E. K. Mohamed, Paul Clarke, Eva Wozniak, Charles Mein, Leslie Schwendimann, Akif Barlas, Philippa Chisholm, Ela Chakkarapani, Adina T. Michael-Titus, Pierre Gressens, Ping K. Yip, Divyen K. Shah

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)

Using next generation sequencing of dried blood spots and subsequent validation, Ponnusamy et al identify let-7b-5p as an elevated microRNA in neonates with moderate to severe encephalopathy. Using cell culture and murine models of perinatal brain in

Externí odkaz: https://doaj.org/article/1be6bfbde1764c6a85fd37f7b2291c5b

Neuronal let-7b-5p acts through the Hippo-YAP pathway in neonatal encephalopathy

Autor: Charles A. Mein, Adina T. Michael-Titus, Ela Chakkarapani, Pierre Gressens, Moumin A. E. K. Mohamed, Eva Wozniak, Leslie Schwendimann, Divyen K Shah, Philippa Chisholm, Akif Barlas, Paul Clarke, Ping K. Yip, Richard T. H. Ip, Vennila Ponnusamy

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biology

Despite increasing knowledge on microRNAs, their role in the pathogenesis of neonatal encephalopathy remains to be elucidated. Herein, we identify let-7b-5p as a significant microRNA in neonates with moderate to severe encephalopathy from dried blood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3308c33a7fb28d9c0b9c251ed914d2
https://doaj.org/article/1be6bfbde1764c6a85fd37f7b2291c5b

Raised Plasma Neurofilament Light Protein Levels After Rewarming Are Associated With Adverse Neurodevelopmental Outcomes in Newborns After Therapeutic Hypothermia

Autor: Philippa Chisholm, Divyen K Shah, Adina T. Michael-Titus, Akif Barlas, Vennila Ponnusamy, Pavithira Tharmapoopathy, Ping K. Yip

Publikováno v: Frontiers in Neurology
Frontiers in Neurology, Vol 11 (2020)

Aim: To determine the predictive value of plasma neurofilament light protein (NfL) as a prognostic marker for outcomes in babies who have undergone therapeutic hypothermia (TH) for hypoxic ischemic encephalopathy (HIE). Method: NfL levels from three

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3d279485daf168eb80a69db581d69a
http://europepmc.org/articles/PMC7644845

WITHDRAWN: In clinical practice, cerebral MRI in newborns is highly predictive of neurodevelopmental outcome after therapeutic hypothermia

Autor: Pavithira Tharmapoopathy, Philippa Chisholm, Akif Barlas, Marianna Varsami, Neelam Gupta, Georgia Ekitzidou, Vennila Ponnusamy, Olga Kappelou, Jane Evanson, Gabriel Rosser, Divyen K. Shah

Publikováno v: European Journal of Paediatric Neurology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7786459ad3c946d7092c5d774a7a9d73
https://doi.org/10.1016/j.ejpn.2019.09.005

Automated electroencephalographic discontinuity in cooled newborns predicts cerebral MRI and neurodevelopmental outcome

Autor: Jonathan M Dunne, Divyen K Shah, James P. Boardman, Olga Kapellou, Philippa Chisholm, David Wertheim, Paul Clarke

Publikováno v: Dunne, J M, Wertheim, D, Clarke, P, Kapellou, O, Chisholm, P, Boardman, J & Shah, D K 2016, ' Automated electroencephalographic discontinuity in cooled newborns predicts cerebral MRI and neurodevelopmental outcome ', Archives of Disease in Childhood . https://doi.org/10.1136/archdischild-2015-309697

BACKGROUND AND HYPOTHESIS: \ud \ud Prolonged electroencephalographic (EEG) discontinuity has been associated with poor neurodevelopmental outcomes after perinatal asphyxia but its predictive value in the era of therapeutic hypothermia (TH) is unknown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b357ebd6968b8580f7f653a07ec2d8
https://pubmed.ncbi.nlm.nih.gov/27103657