Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Philipp Tomsits"'
Autor:
Julia Bauer, Julia Vlcek, Valerie Pauly, Nora Hesse, Ruibing Xia, Li Mo, Aparna Sharma Chivukula, Hannes Villgrater, Marie Dressler, Bianca Hildebrand, Eckhard Wolf, Konstantinos D. Rizas, Axel Bauer, Stefan Kääb, Philipp Tomsits, Dominik Schüttler, Sebastian Clauss
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 9 (2024)
Background Periodic repolarization dynamics (PRD) is an electrocardiographic biomarker that captures repolarization instability in the low frequency spectrum and is believed to estimate the sympathetic effect on the ventricular myocardium. High PRD i
Externí odkaz:
https://doaj.org/article/ec48d6e8e9fe460fbf10c6b6402d7e9c
Autor:
Fitzwilliam Seibertz, Markus Rapedius, Funsho E. Fakuade, Philipp Tomsits, Aiste Liutkute, Lukas Cyganek, Nadine Becker, Rupamanjari Majumder, Sebastian Clauß, Niels Fertig, Niels Voigt
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
An altered automated patch-clamp (APC) approach enables high-throughput recordings from native pig cardiomyocytes and human iPSC-derived cardiomyocytes.
Externí odkaz:
https://doaj.org/article/5c7c79c8eaee40c1b5ac7523e292a2bf
Autor:
Ruibing Xia, Philipp Tomsits, Simone Loy, Zhihao Zhang, Valerie Pauly, Dominik Schüttler, Sebastian Clauss
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Cardiac electrophysiology is a complex system established by a plethora of inward and outward ion currents in cardiomyocytes generating and conducting electrical signals in the heart. However, not only cardiomyocytes but also other cell types can mod
Externí odkaz:
https://doaj.org/article/870bf62b217f471e9bf8c38cfeb88cfa
Autor:
Valerie Pauly, Julia Vlcek, Zhihao Zhang, Nora Hesse, Ruibing Xia, Julia Bauer, Simone Loy, Sarah Schneider, Simone Renner, Eckhard Wolf, Stefan Kääb, Dominik Schüttler, Philipp Tomsits, Sebastian Clauss
Publikováno v:
Cells, Vol 12, Iss 7, p 973 (2023)
Atrial fibrillation (AF) is the most prevalent arrhythmia, often caused by myocardial ischemia/infarction (MI). Men have a 1.5× higher prevalence of AF, whereas women show a higher risk for new onset AF after MI. However, the underlying mechanisms o
Externí odkaz:
https://doaj.org/article/aa21fbdebe6344298b3f2eaa5627eecf
Autor:
Susanne Rinné, Annemarie Oertli, Claudia Nagel, Philipp Tomsits, Tina Jenewein, Stefan Kääb, Silke Kauferstein, Axel Loewe, Britt Maria Beckmann, Niels Decher
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1350 (2023)
The KCNQ1 gene encodes the α-subunit of the cardiac voltage-gated potassium (Kv) channel KCNQ1, also denoted as Kv7.1 or KvLQT1. The channel assembles with the ß-subunit KCNE1, also known as minK, to generate the slowly activating cardiac delayed r
Externí odkaz:
https://doaj.org/article/756cf7ea2a0e4900a17133d511bd2adf
Autor:
Philipp Tomsits, Lina Volz, Ruibing Xia, Aparna Chivukula, Dominik Schüttler, Sebastian Clauß
Publikováno v:
Lab Animal. 52:85-92
Arrhythmias are critical contributors to cardiovascular morbidity and mortality. Therapies are mainly symptomatic and often insufficient, emphasizing the need for basic research to unveil the mechanisms underlying arrhythmias and to enable better and
Autor:
Sebastian Clauss, Dominik Schüttler, Christina Bleyer, Julia Vlcek, Mehdi Shakarami, Philipp Tomsits, Sarah Schneider, Florian Maderspacher, Kavi Chataut, Anna Trebo, Christine Wang, Jan Kleeberger, Ruibing Xia, Elisabeth Baloch, Bianca Hildebrand, Steffen Massberg, Reza Wakili, Stefan Kääb
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232374 (2020)
Atrial fibrillation (AF) is a major healthcare challenge contributing to high morbidity and mortality. Treatment options are still limited, mainly due to insufficient understanding of the underlying pathophysiology. Further research and the developme
Externí odkaz:
https://doaj.org/article/f2090773d7044e99aecaa468c7137ee2
Autor:
Dominik Schüttler, Philipp Tomsits, Christina Bleyer, Julia Vlcek, Valerie Pauly, Nora Hesse, Moritz Sinner, Daphne Merkus, Jules Hamers, Stefan Kääb, Sebastian Clauss
Publikováno v:
Lab Animal. 51:46-67
Over the past years, the use of large animals has become increasingly interesting in translational research, to bridge the gap between basic research in rodents and targeted therapies in humans. Pigs are highly valued in cardiovascular research becau
Autor:
Charlotte Glinge, Sebastian Clauss, Kim Boddum, Reza Jabbari, Javad Jabbari, Bjarke Risgaard, Philipp Tomsits, Bianca Hildebrand, Stefan Kääb, Reza Wakili, Thomas Jespersen, Jacob Tfelt-Hansen
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0167969 (2017)
BACKGROUND AND AIM:The potential of microRNAs (miRNA) as non-invasive diagnostic, prognostic, and predictive biomarkers, as well as therapeutic targets, has recently been recognized. Previous studies have highlighted the importance of consistency in
Externí odkaz:
https://doaj.org/article/1a88d2d592c841eea3a9643f9936cd84
Autor:
Philipp, Tomsits, Aparna, Sharma Chivukula, Kavi, Raj Chataut, Agus, Simahendra, Ludwig T, Weckbach, Stefan, Brunner, Sebastian, Clauss
Publikováno v:
Journal of Visualized Experiments.
Regular physical exercise is a major contributor to cardiovascular health, influencing various metabolic as well as electrophysiological processes. However, in certain cardiac diseases such as inherited arrhythmia syndromes, e.g., arrhythmogenic card