Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Philipp Steven"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Meibomian glands (MG) are large sebaceous glands located below the tarsal conjunctiva and the abnormalities of these glands cause Meibomian gland dysfunction (MGD) which is responsible for evaporative dry eye disease (DED). Accurate MG segme
Externí odkaz:
https://doaj.org/article/81521c54131d43678c2babeb7875e399
Autor:
Anusha Balla, Bao Tran, Annika Valtari, Philipp Steven, Camilla Scarpellini, Koen Augustyns, Arto Urtti, Kati-Sisko Vellonen, Marika Ruponen
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 118 (2022)
Corneal wound, associated with pain, impaired vision, and even blindness, is the most common ocular injury. In this study, we investigated the effect of a novel ferroptosis inhibitor, UAMC-3203 (10 nM–50 µM), in corneal epithelial wound healing in
Externí odkaz:
https://doaj.org/article/d1136f4a281c4e77b6f05239a3ddcb2a
Autor:
Nikolaos Katsinas, Uta Gehlsen, Laura García-Posadas, Soraya Rodríguez-Rojo, Philipp Steven, María J. González-García, Amalia Enríquez-de-Salamanca
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 16, p 4703 (2022)
Dry eye (DED) is a prevalent disease with immune-mediated inflammation as the principal pathophysiological etiology. Olive pomace, the major by-product of the olive oil industry, is rich in high-value polyphenols. Their anti-inflammatory and immunomo
Externí odkaz:
https://doaj.org/article/7cf7d7ab05554dd0adf31d60a5878bf5
Autor:
Eugene Appenteng Osae, Reynolds Kwame Ablorddepey, Jens Horstmann, David Ben Kumah, Philipp Steven
Publikováno v:
BMC Ophthalmology, Vol 18, Iss 1, Pp 1-8 (2018)
Abstract Background Meibomian Gland Dysfunction (MGD) is a leading cause of evaporative Dry Eye Disease (DED). This makes non-invasive meibography an important procedure in the clinical evaluation of DED patients. Our purpose was to conduct a lead-of
Externí odkaz:
https://doaj.org/article/752582516f16431bb9fa39e179b5f14d
Autor:
Uta Gehlsen, Daniela Stary, Martina Maass, Katarina Riesner, Gwen Musial, Michael E. Stern, Olaf Penack, Philipp Steven
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6191 (2021)
Ocular graft-versus-host disease (oGVHD) is a fast progressing, autoimmunological disease following hematopoietic stem cell transplantation, leading to severe inflammation of the eye and destruction of the lacrimal functional unit with consecutive si
Externí odkaz:
https://doaj.org/article/17eeb76b82a0472ead9e0bfbab6c9e0f
Autor:
Deniz Hos, Anne Bukowiecki, Jens Horstmann, Felix Bock, Franziska Bucher, Ludwig M. Heindl, Sebastian Siebelmann, Philipp Steven, Reza Dana, Sabine A. Eming, Claus Cursiefen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Lymphangiogenesis is essential for fluid homeostasis in vascularized tissues. In the normally avascular cornea, however, pathological lymphangiogenesis mediates diseases like corneal transplant rejection, dry eye disease, and allergy. So far
Externí odkaz:
https://doaj.org/article/053fbcf09c38419296950040ef200857
Autor:
Eugene Appenteng Osae, Philipp Steven
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3516 (2021)
Despite decades of experience with hematopoietic stem cell transplantation, we are still faced with the delicate equipoise of achieving stable ocular health post-transplantation. This is because ocular graft-versus-host disease (oGvHD) following hema
Externí odkaz:
https://doaj.org/article/8e9efa52d5fd4ec0b9846b70d992d8c4
Autor:
Eugene A. Osae, Tiffany Bullock, Madhavi Chintapalati, Susanne Brodesser, Samuel Hanlon, Rachel Redfern, Philipp Steven, C. Wayne Smith, Rolando E. Rumbaut, Alan R. Burns
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8772 (2020)
Background: Dyslipidemia may be linked to meibomian gland dysfunction (MGD) and altered meibum lipid composition. The purpose was to determine if plasma and meibum cholesteryl esters (CE), triglycerides (TG), ceramides (Cer) and sphingomyelins (SM) c
Externí odkaz:
https://doaj.org/article/db70843af57d4f2b869decc05430bc09
Autor:
Philipp Steven, Sebastian Schwab, Anne Kiesewetter, Daniel R. Saban, Michael E. Stern, Uta Gehlsen
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7514 (2020)
Conjunctiva-associated tissue (CALT) is assumed to play a crucial role in the immune system of the ocular surface. Its function in several ocular surface diseases (OSD) is still not fully understood. This study investigates the function of CALT in mo
Externí odkaz:
https://doaj.org/article/96a3f0042785491dac224f8090c9a527
Autor:
Eugene A. Osae, Philipp Steven, Rachel Redfern, Samuel Hanlon, C. Wayne Smith, Rolando E. Rumbaut, Alan R. Burns
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3505 (2019)
Meibomian gland dysfunction (MGD) is the leading cause of dry eye disease and loss of ocular surface homeostasis. Increasingly, several observational clinical studies suggest that dyslipidemia (elevated blood cholesterol, triglyceride or lipoprotein
Externí odkaz:
https://doaj.org/article/082979fc54d8418f9a6411f91ec497f4