Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Philipp Spatz"'
Autor:
Philipp Spatz, Sophie A. M. Steinmüller, Anna Tutov, Eleonora Poeta, Axelle Morilleau, Allison Carles, Marie H. Deventer, Julian Hofmann, Christophe P. Stove, Barbara Monti, Tangui Maurice, Michael Decker
Publikováno v:
Journal of Medicinal Chemistry. 66:6414-6435
Autor:
Philipp Spatz, Thomas Zimmermann, Sophie Steinmüller, Julian Hofmann, Tangui Maurice, Michael Decker
Publikováno v:
RSC Med Chem
As levels of acetylcholinesterase (AChE) decrease while levels of butyrylcholinesterase (BChE) increase in later stages of Alzheimer's disease (AD), BChE stands out as a promising target for treatment of AD. Therefore, several benzimidazole-carbamate
Autor:
Julian Hofmann, Philipp Spatz, Rasmus Walther, Marcus Gutmann, Tangui Maurice, Michael Decker
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 28(39)
Flavonoids are polyphenolic natural products and have shown significant potential as disease-modifying agents against neurodegenerative disorders like Alzheimer's disease (AD), with activities even in vivo. Hybridization of the natural products taxif
Autor:
Philipp Spatz, Takahiro Higuchi, Urban Košak, Damijan Knez, Naoko Nose, Stanislav Gobec, Michael Decker, Xinyu Chen, Christian Gentzsch
Purpose A neuropathological hallmark of Alzheimer’s disease (AD) is the presence of amyloid-β (Aβ) plaques in the brain, which are observed in a significant number of cognitively normal, older adults as well. In AD, butyrylcholinesterase (BChE) b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d7bd2b15e59a7a1bd36a74951179c5
https://opus.bibliothek.uni-wuerzburg.de/files/26987/Gentzsch_Molecular.pdf
https://opus.bibliothek.uni-wuerzburg.de/files/26987/Gentzsch_Molecular.pdf
Autor:
Christian, Gentzsch, Xinyu, Chen, Philipp, Spatz, Urban, Košak, Damijan, Knez, Naoko, Nose, Stanislav, Gobec, Takahiro, Higuchi, Michael, Decker
Publikováno v:
Molecular Imaging and Biology
Purpose A neuropathological hallmark of Alzheimer’s disease (AD) is the presence of amyloid-β (Aβ) plaques in the brain, which are observed in a significant number of cognitively normal, older adults as well. In AD, butyrylcholinesterase (BChE) b
Autor:
Hans-Jürgen Wester, Veronika Stiegler, Dominik Reich, Philipp Spatz, Julia Pollmann, Alexander Wurzer, Martina Wirtz, Johannes Notni
Publikováno v:
Chemical communications (Cambridge, England). 53(17)
Starting from multifunctional triazacyclononane-triphosphinate chelator cores, dendritic molecules with the ability to bind metal ions within their framework were synthesized. A cooperative interaction of the chelator cages resulted in a markedly inc