Výsledky vyhledávání - "Philipp Spatz"

Novel benzimidazole-based pseudo-irreversible butyrylcholinesterase inhibitors with neuroprotective activity in an Alzheimer's disease mouse model

Autor: Philipp Spatz, Thomas Zimmermann, Sophie Steinmüller, Julian Hofmann, Tangui Maurice, Michael Decker

Publikováno v: RSC Med Chem

As levels of acetylcholinesterase (AChE) decrease while levels of butyrylcholinesterase (BChE) increase in later stages of Alzheimer's disease (AD), BChE stands out as a promising target for treatment of AD. Therefore, several benzimidazole-carbamate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7878bd8cfb23a0ffd7d30164cf2d0ced
https://doi.org/10.1039/d2md00087c

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Synthesis and Biological Evaluation of Flavonoid-Cinnamic Acid Amide Hybrids with Distinct Activity against Neurodegeneration in Vitro and in Vivo

Autor: Julian Hofmann, Philipp Spatz, Rasmus Walther, Marcus Gutmann, Tangui Maurice, Michael Decker

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 28(39)

Flavonoids are polyphenolic natural products and have shown significant potential as disease-modifying agents against neurodegenerative disorders like Alzheimer's disease (AD), with activities even in vivo. Hybridization of the natural products taxif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0167b72be12e9c304bbcdfa12ab79c5
https://pubmed.ncbi.nlm.nih.gov/35621167

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Synthesis and Initial Characterization of a Reversible, Selective \(^{18}\)F-Labeled Radiotracer for Human Butyrylcholinesterase

Autor: Philipp Spatz, Takahiro Higuchi, Urban Košak, Damijan Knez, Naoko Nose, Stanislav Gobec, Michael Decker, Xinyu Chen, Christian Gentzsch

Purpose A neuropathological hallmark of Alzheimer’s disease (AD) is the presence of amyloid-β (Aβ) plaques in the brain, which are observed in a significant number of cognitively normal, older adults as well. In AD, butyrylcholinesterase (BChE) b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d7bd2b15e59a7a1bd36a74951179c5
https://opus.bibliothek.uni-wuerzburg.de/files/26987/Gentzsch_Molecular.pdf

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Synthesis and Initial Characterization of a Reversible, Selective

Autor: Christian, Gentzsch, Xinyu, Chen, Philipp, Spatz, Urban, Košak, Damijan, Knez, Naoko, Nose, Stanislav, Gobec, Takahiro, Higuchi, Michael, Decker

Publikováno v: Molecular Imaging and Biology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88a3da203952b27c71ba637a2ac3d6d6
https://pubmed.ncbi.nlm.nih.gov/33660167

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Dendritic poly-chelator frameworks for multimeric bioconjugation

Autor: Hans-Jürgen Wester, Veronika Stiegler, Dominik Reich, Philipp Spatz, Julia Pollmann, Alexander Wurzer, Martina Wirtz, Johannes Notni

Publikováno v: Chemical communications (Cambridge, England). 53(17)

Starting from multifunctional triazacyclononane-triphosphinate chelator cores, dendritic molecules with the ability to bind metal ions within their framework were synthesized. A cooperative interaction of the chelator cages resulted in a markedly inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b0f16c719440eaf9ab43321f1876c4
https://pubmed.ncbi.nlm.nih.gov/28191563

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Akademický článek

Synthesis and Biological Evaluation of Flavonoid‐Cinnamic Acid Amide Hybrids with Distinct Activity against Neurodegeneration in Vitro and in Vivo.

Autor: Hofmann, Julian¹ (AUTHOR), Spatz, Philipp¹ (AUTHOR), Walther, Rasmus¹ (AUTHOR), Gutmann, Marcus² (AUTHOR), Maurice, Tangui³ (AUTHOR), Decker, Michael¹ (AUTHOR) michael.decker@uni-wuerzburg.de

Publikováno v: Chemistry - A European Journal. 7/11/2022, Vol. 28 Issue 39, p1-16. 16p.

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