α-Synuclein plasma membrane localization correlates with cellular phosphatidylinositol polyphosphate levels

Autor: Reeba Susan Jacob, Cédric Eichmann, Alessandro Dema, Davide Mercadante, Philipp Selenko

Publikováno v: eLife, Vol 10 (2021)

The Parkinson’s disease protein α-synuclein (αSyn) promotes membrane fusion and fission by interacting with various negatively charged phospholipids. Despite postulated roles in endocytosis and exocytosis, plasma membrane (PM) interactions of αS

Externí odkaz: https://doaj.org/article/6639fa7bd134425bb132e8bc8c89d928

Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites

Autor: Andres Binolfi, Antonio Limatola, Silvia Verzini, Jonas Kosten, Francois-Xavier Theillet, Honor May Rose, Beata Bekei, Marchel Stuiver, Marleen van Rossum, Philipp Selenko

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)

α-synuclein is a protein linked to the occurrence of Parkinson's disease. Here, the authors use time-resolved in-cell NMR spectroscopy to study the repair of methionine-oxidized α-synuclein by endogenous cellular enzymes.

Externí odkaz: https://doaj.org/article/7fb253fdcc4e4807873bdf93d8263baf

Mechanical stress impairs pheromone signaling via Pkc1-mediated regulation of the MAPK scaffold Ste5

Autor: Andres Binolfi, Philipp Selenko, Gerhard Wider, Zinaida Yudina, Björn Hegemann, Serge Pelet, Ranjan Mishra, Michal J. Walczak, Gustav Ammerer, Matthias Peter, Wolfgang Reiter, Fabian Rudolf, Ilse Dohnal, Sung Sik Lee, Frank van Drogen

Publikováno v: Journal of Cell Biology
The Journal of Cell Biology
The Journal of cell biology, vol. 218, no. 9, pp. 3117-3133
The Journal of Cell Biology, 218 (7)

Cells continuously adapt cellular processes by integrating external and internal signals. In yeast, multiple stress signals regulate pheromone signaling to prevent mating under unfavorable conditions. However, the underlying crosstalk mechanisms rema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086077ae92b6a41569f5e2030d91cb05
https://doi.org/10.1083/jcb.201808161

Megadalton-sized dityrosine aggregates of α-synuclein retain high degrees of structural disorder and internal dynamics

Autor: Philipp Selenko, Adam Belsom, Juri Rappsilber, Erich E. Wanker, Maliah Shah, Andres Binolfi, Jan Bieschke, Francois-Xavier Theillet, Silvia Verzini

Heterogeneous aggregates of the human protein α-synuclein (αSyn) are abundantly found in Lewy body inclusions of Parkinson’s disease patients. While structural information on classical αSyn amyloid fibrils is available, little is known about the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44ec3e6d896b3bdb9b371617de96a93f
https://doi.org/10.1101/2020.07.26.202358

Author response: Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology

Autor: Arsen Petrovic, Stephanie Voss, Giuseppe Ciossani, Valentina Piano, Katharina Overlack, Beate Voss, Stefano Maffini, Yao-Wen Wu, Philipp Selenko, Sabine Wohlgemuth, Marchel Stuiver, Andrea Musacchio, Amal Alex, Soumitra Polley

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97fb0e509c56b5bfce1ef645a162cdfe
https://doi.org/10.7554/elife.48287.024