Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Philipp Schreppel"'
Autor:
Lanxin Luo, Jun Wang, Dawei Ding, Md Nabiul Hasan, Sung-Sen Yang, Shih-Hua Lin, Philipp Schreppel, Baoshan Sun, Yan Yin, Thomas Erker, Dandan Sun
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Introduction: Na+-K+-2Cl− cotransporter isoform 1 (NKCC1) is important in regulating intracellular K+ and Cl− homeostasis and cell volume. In this study, we investigated a role of NKCC1 in regulating glioma K+ influx and proliferation in response
Externí odkaz:
https://doaj.org/article/12fe751a292449c5b17969be452db028
Autor:
Sung-Sen Yang, Shih-Hua Lin, Zhongling Zhang, Sandhya Shankar, Shanshan Song, Bradley J. Molyneaux, Huachen Huang, Eric Li, Philipp Schreppel, Taraneh Taheri, Dandan Sun, Tong Jiang, Mohammad Iqbal H. Bhuiyan, Thomas Erker, Michael Hintersteininger
Publikováno v:
Stroke. 50:1021-1025
Background and Purpose— Inhibition of brain NKCC1 (Na + -K + -Cl − cotransporter 1) with bumetanide (BMT) is of interest in ischemic stroke therapy. However, its poor brain penetration limits the application. In this study, we investigated the ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76ccbd4937f3d0311d199e47c1d343aa
https://doi.org/10.1161/strokeaha.118.024287
https://doi.org/10.1161/strokeaha.118.024287
Autor:
Yan Yin, Jun Wang, Baoshan Sun, Shih-Hua Lin, Lanxin Luo, Dawei Ding, Dandan Sun, Thomas Erker, Nabiul Hasan, Philipp Schreppel, Sung-Sen Yang
Publikováno v:
Frontiers in Physiology
Frontiers in Physiology, Vol 11 (2020)
Frontiers in Physiology, Vol 11 (2020)
Introduction: Na+-K+-2Cl- cotransporter isoform 1 (NKCC1) is important in regulating intracellular K+ and Cl- homeostasis and cell volume. In this study, we investigated a role of NKCC1 in regulating glioma K+ influx and proliferation in response to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ae4088e88433b30e0b606c432ad0b0
http://europepmc.org/articles/PMC7413028
http://europepmc.org/articles/PMC7413028
Publikováno v:
Pharmacologytherapeutics. 205
Epilepsies represent one of the most common neurological diseases worldwide. They are characterized by recurrent spontaneous seizures with severe impact on a patient’s life. An imbalance in excitatory and inhibitory signalling is considered the mai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e744a190f9863a56457f4ffc4cad82c
https://pubmed.ncbi.nlm.nih.gov/31626872
https://pubmed.ncbi.nlm.nih.gov/31626872
Publikováno v:
Neuropharmacology. 162
Temporal lobe epilepsy (TLE) is the most common type of focal epilepsies, affecting approximately 35 million people worldwide. Despite the introduction of numerous novel antiepileptic drugs during the last decades, the proportion of patients with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::782fa961b0709fe615b203867a66f8a3
https://pubmed.ncbi.nlm.nih.gov/31476353
https://pubmed.ncbi.nlm.nih.gov/31476353
Autor:
Huachen, Huang, Mohammad Iqbal H, Bhuiyan, Tong, Jiang, Shanshan, Song, Sandhya, Shankar, Taraneh, Taheri, Eric, Li, Philipp, Schreppel, Michael, Hintersteininger, Sung-Sen, Yang, Shih-Hua, Lin, Bradley J, Molyneaux, Zhongling, Zhang, Thomas, Erker, Dandan, Sun
Publikováno v:
Stroke. 50(4)
BACKGROUND AND PURPOSE: Inhibition of brain Na(+)-K(+)-Cl(−) cotransporter 1 (NKCC1) with bumetanide (BMT) is of interest in ischemic stroke therapy. However, its poor brain penetration limits the application. In this study, we investigated the eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4acfad4671ef72cca49be7a788230ed3
https://pubmed.ncbi.nlm.nih.gov/30862257
https://pubmed.ncbi.nlm.nih.gov/30862257
Autor:
Kathrin Töllner, Thomas Erker, Friederike Twele, Philipp Schreppel, Alina Schidlitzki, Wolfgang Löscher, Claudia Brandt
Publikováno v:
Epilepsia. 57:698-705
The loop diuretic bumetanide has been reported to potentiate the antiseizure activity of phenobarbital in rodent models of neonatal seizures, most likely as a result of inhibition of the chloride importer Na-K-Cl cotransporter isoform 1 (NKCC1) in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae98deccd06b0d9341b22755ce6e85f2
https://doi.org/10.1111/epi.13346
https://doi.org/10.1111/epi.13346
Autor:
Thomas Erker, Tong Jiang, Michael Hintersteininger, Sandhya Shankar, Mohammad Iqbal H. Bhuiyan, Dandan Sun, Philipp Schreppel, Huachen Huang
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08658479dbe88affac4d82440851d7f5
https://doi.org/10.1096/fasebj.2018.32.1_supplement.824.2
https://doi.org/10.1096/fasebj.2018.32.1_supplement.824.2
Autor:
Norbert Handler, Jenny Breitenbach, Katrin Goldhahn, Silvia Loebsch, Thomas Erker, Burkhard Kloesch, Philipp Schreppel
Publikováno v:
Natural Product Communications. 11:1934578X1601101
Genistein, a naturally occurring isoflavone, possesses many beneficial health effects. To improve the bioactivity of the natural compound, we designed and synthesized the genistein prodrug FEHH6-1. In the present study, we evaluated the biological ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5122f941d165389fdbe1eb5c36f98028
https://doi.org/10.1177/1934578x1601101006
https://doi.org/10.1177/1934578x1601101006