Výsledky vyhledávání - "Philipp Schachtschneider"

Supplementary Fig. S1 from Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes

Autor: Oliver Stoeltzing, Edward K. Geissler, Hans J. Schlitt, David Batt, Andreas Gaumann, Christina Hackl, Akira Mori, Christian Moser, Philipp Schachtschneider, Sven A. Lang

Supplementary Fig. S1 from Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72602e2e3037c0e98d118eddb7291119
https://doi.org/10.1158/1535-7163.22483097.v1

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Supplementary Fig. S3 from Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes

Autor: Oliver Stoeltzing, Edward K. Geissler, Hans J. Schlitt, David Batt, Andreas Gaumann, Christina Hackl, Akira Mori, Christian Moser, Philipp Schachtschneider, Sven A. Lang

Supplementary Fig. S3 from Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3847a0094ccb9cb5b31a8b0eea7c18a6
https://doi.org/10.1158/1535-7163.22483091.v1

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Data from Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes

Autor: Oliver Stoeltzing, Edward K. Geissler, Hans J. Schlitt, David Batt, Andreas Gaumann, Christina Hackl, Akira Mori, Christian Moser, Philipp Schachtschneider, Sven A. Lang

The Ras/Raf/MEK pathway represents an important oncogenic signaling pathway in gastrointestinal malignancies, including pancreatic cancer. Although activating B-Raf mutations are infrequent in pancreatic cancer, we hypothesized that targeting Raf cou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107e50c1e4608618ad022f4a02cf96c1
https://doi.org/10.1158/1535-7163.c.6531068

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Supplementary Fig. S2 from Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes

Autor: Oliver Stoeltzing, Edward K. Geissler, Hans J. Schlitt, David Batt, Andreas Gaumann, Christina Hackl, Akira Mori, Christian Moser, Philipp Schachtschneider, Sven A. Lang

Supplementary Fig. S2 from Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5a64e240da4cec7ab43020d93efd49
https://doi.org/10.1158/1535-7163.22483094

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Targeting heat-shock protein 90 improves efficacy of rapamycin in a model of hepatocellular carcinoma in mice

Autor: Oliver Stoeltzing, Stefan Fichnter-Feigl, Hans J. Schlitt, Sven A. Lang, Philipp Schachtschneider, Volker Schmitz, Claus Hellerbrand, Edward K Geissler, Christian Moser

Publikováno v: Hepatology (Baltimore, Md.). 49(2)

Hepatocellular carcinoma (HCC) remains associated with a poor prognosis, but novel targeted therapies in combination with anti-angiogenic substances may offer new perspectives. We hypothesized that simultaneous targeting of tumor cells, endothelial c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ab0cf3e5327e6c90fd41b6326bcf33
https://pubmed.ncbi.nlm.nih.gov/19085954

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Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes

Autor: Edward K. Geissler, Christian Moser, Hans J. Schlitt, Akira Mori, Philipp Schachtschneider, Christina Hackl, Sven A. Lang, Oliver Stoeltzing, David Bryant Batt, Andreas Gaumann

Publikováno v: Molecular cancer therapeutics. 7(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056ea2c745ebfb41713359fd31ae9f6e
https://pubmed.ncbi.nlm.nih.gov/19001434

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Inhibition of insulin-like growth factor-I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis

Autor: Hans J. Schlitt, Oliver Stoeltzing, Akira Mori, Sven A. Lang, Christian Moser, Edward K. Geissler, Philipp Schachtschneider, Andreas Gaumann, Johann Zimmermann

Publikováno v: European journal of cancer (Oxford, England : 1990). 44(11)

The insulin-like growth factor-I receptor (IGF-IR) is frequently overexpressed and constitutively activated in pancreatic cancer, thus representing a promising target for therapy. We investigated the impact of a novel inhibitor of IGF-IR (NVP-AEW541)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11e7ba14c6a1fb0011ad4e36ad5a75f
https://pubmed.ncbi.nlm.nih.gov/18445520

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Kombinierte Inhibition von Raf-Kinase und IGF-IR blockiert multiple pro-angiogenetische Signalwege und steigert die Chemosensitivität humaner Pankreaskarzinomzellen

Autor: B. Kaufmann, Sa Lang, Philipp Schachtschneider, O. Stöltzing, C. Zülke, Christian Moser, HJ Schlitt, Edward K. Geissler

Publikováno v: 124. Kongress der Deutschen Gesellschaft für Chirurgie; 20070501-20070504; München; DOC07dgch7110 /20071001/
Chirurgisches Forum 2007 ISBN: 9783540711223

Overexpression of IGF-I/IGF-IR and activation of Ras/Raf signaling cascades have been implicated in angiogenesis and progression of human pancreatic cancer. Both signaling systems may up-regulate VEGF expression and mediate anti-apoptotic effects, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80bd9343637651c0bbcb0c770b28645e
http://www.egms.de/en/meetings/dgch2007/07dgch065.shtml

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