Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Philipp Sasse"'
Autor:
Patrick Leven, Reiner Schneider, Linda Schneider, Shilpashree Mallesh, Pieter Vanden Berghe, Philipp Sasse, Jörg C. Kalff, Sven Wehner
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-23 (2023)
Abstract Background Enteric glia contribute to the pathophysiology of various intestinal immune-driven diseases, such as postoperative ileus (POI), a motility disorder and common complication after abdominal surgery. Enteric gliosis of the intestinal
Externí odkaz:
https://doaj.org/article/a62b09c1d2ec4c5c8f34d52d0f47a28c
Autor:
Tobias Benkel, Mirjam Zimmermann, Julian Zeiner, Sergi Bravo, Nicole Merten, Victor Jun Yu Lim, Edda Sofie Fabienne Matthees, Julia Drube, Elke Miess-Tanneberg, Daniela Malan, Martyna Szpakowska, Stefania Monteleone, Jak Grimes, Zsombor Koszegi, Yann Lanoiselée, Shannon O’Brien, Nikoleta Pavlaki, Nadine Dobberstein, Asuka Inoue, Viacheslav Nikolaev, Davide Calebiro, Andy Chevigné, Philipp Sasse, Stefan Schulz, Carsten Hoffmann, Peter Kolb, Maria Waldhoer, Katharina Simon, Jesus Gomeza, Evi Kostenis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Abstract Carvedilol is among the most effective β-blockers for improving survival after myocardial infarction. Yet the mechanisms by which carvedilol achieves this superior clinical profile are still unclear. Beyond blockade of β1-adrenoceptors, ar
Externí odkaz:
https://doaj.org/article/31913551d70443ecbc6be0521f89476a
Autor:
Sammy Kimoloi, Ayesha Sen, Stefan Guenther, Thomas Braun, Tobias Brügmann, Philipp Sasse, Rudolf J. Wiesner, David Pla‐Martín, Olivier R. Baris
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 4, Pp 2132-2145 (2022)
Abstract Background Mitochondrial dysfunction caused by mitochondrial (mtDNA) deletions have been associated with skeletal muscle atrophy and myofibre loss. However, whether such defects occurring in myofibres cause sarcopenia is unclear. Also, the c
Externí odkaz:
https://doaj.org/article/15e959a1114e4a8dadd0b7d4b985fc9e
Autor:
Ahmed Wagdi, Daniela Malan, Udhayabhaskar Sathyanarayanan, Janosch S. Beauchamp, Markus Vogt, David Zipf, Thomas Beiert, Berivan Mansuroglu, Vanessa Dusend, Mark Meininghaus, Linn Schneider, Bernd Kalthof, J. Simon Wiegert, Gabriele M. König, Evi Kostenis, Robert Patejdl, Philipp Sasse, Tobias Bruegmann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Gq proteins are one of four major classes of G proteins; optogenetic receptors for selective and repetitive activation of Gq proteins with fast kinetics are lacking. Here the authors report UV light-dependent Gq signalling using human Neuropsin (hOPN
Externí odkaz:
https://doaj.org/article/a279b477c4f4465bb0b225dabc9ba09a
Autor:
Xiaochun Cao-Ehlker, Carola Fischer, Kun Lu, Tobias Bruegmann, Philipp Sasse, Andreas Dendorfer, Roland Tomasi
Publikováno v:
Bioengineering, Vol 10, Iss 2, p 171 (2023)
Organotypic heart slices from mice might provide a promising in vitro model for cardiac research because of the vast availability of genetically modified specimens, combined with the unrestricted feasibility of experimental interventions. However, mu
Externí odkaz:
https://doaj.org/article/49e70150c12e41e6a492d76f511dc30f
Autor:
Ahmed Wagdi, Daniela Malan, Udhayabhaskar Sathyanarayanan, Janosch S. Beauchamp, Markus Vogt, David Zipf, Thomas Beiert, Berivan Mansuroglu, Vanessa Dusend, Mark Meininghaus, Linn Schneider, Bernd Kalthof, J. Simon Wiegert, Gabriele M. König, Evi Kostenis, Robert Patejdl, Philipp Sasse, Tobias Bruegmann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/8eaba225fb6a43418e646ee10581c265
Optogenetic Stimulation of Gi Signaling Enables Instantaneous Modulation of Cardiomyocyte Pacemaking
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
G-protein signaling pathways are central in the regulation of cardiac function in physiological and pathophysiological conditions. Their functional analysis through optogenetic techniques with selective expression of opsin proteins and activation by
Externí odkaz:
https://doaj.org/article/6a9a914974594e0097fc6dabf585064d
Autor:
M. Caroline Müllenbroich, Allen Kelly, Corey Acker, Gil Bub, Tobias Bruegmann, Anna Di Bona, Emilia Entcheva, Cecilia Ferrantini, Peter Kohl, Stephan E. Lehnart, Marco Mongillo, Camilla Parmeggiani, Claudia Richter, Philipp Sasse, Tania Zaglia, Leonardo Sacconi, Godfrey L. Smith
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Optical techniques for recording and manipulating cellular electrophysiology have advanced rapidly in just a few decades. These developments allow for the analysis of cardiac cellular dynamics at multiple scales while largely overcoming the drawbacks
Externí odkaz:
https://doaj.org/article/a9e4c73a9f3a472da2cc8abc80c6b389
Autor:
Philipp Makowka, Tobias Bruegmann, Vanessa Dusend, Daniela Malan, Thomas Beiert, Michael Hesse, Bernd K. Fleischmann, Philipp Sasse
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Studying adrenergic signalling in the heart requires perfusion with receptor agonists, which lacks cell specificity and spatiotemporal control. Here the authors use the light sensitive G-coupled receptor JellyOp to optogenetically control Gs-signalin
Externí odkaz:
https://doaj.org/article/bdc7336dcc0d428d9963e651e1b882f9
Autor:
Wilhelm Roell, Alexandra M. Klein, Martin Breitbach, Torsten S. Becker, Ashish Parikh, Jane Lee, Katrin Zimmermann, Shaun Reining, Beth Gabris, Annika Ottersbach, Robert Doran, Britta Engelbrecht, Miriam Schiffer, Kenichi Kimura, Patricia Freitag, Esther Carls, Caroline Geisen, Georg D. Duerr, Philipp Sasse, Armin Welz, Alexander Pfeifer, Guy Salama, Michael Kotlikoff, Bernd K. Fleischmann
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Ventricular tachycardia (VT) is the most common and potentially lethal complication following myocardial infarction (MI). Biological correction of the conduction inhomogeneity that underlies re-entry could be a major advance in infarction th
Externí odkaz:
https://doaj.org/article/3cdf27391ef1464998db4351fd85b5c0