Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Philipp S, Orekhov"'
Autor:
Rafael Ayala, Andrey V. Moiseenko, Ting-Hua Chen, Eugene E. Kulikov, Alla K. Golomidova, Philipp S. Orekhov, Maya A. Street, Olga S. Sokolova, Andrey V. Letarov, Matthias Wolf
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The T5 family of viruses are tailed bacteriophages characterized by a long non-contractile tail. The bacteriophage DT57C is closely related to the paradigmal T5 phage, though it recognizes a different receptor (BtuB) and features highly dive
Externí odkaz:
https://doaj.org/article/ef3cb953302448e4932bc9f692c9ad41
Autor:
Yury L. Ryzhykau, Philipp S. Orekhov, Maksim I. Rulev, Alexey V. Vlasov, Igor A. Melnikov, Dmytro A. Volkov, Mikhail Yu. Nikolaev, Dmitrii V. Zabelskii, Tatiana N. Murugova, Vladimir V. Chupin, Andrey V. Rogachev, Andrey Yu. Gruzinov, Dmitri I. Svergun, Martha E. Brennich, Ivan Yu. Gushchin, Montserrat Soler-Lopez, Arne Bothe, Georg Büldt, Gordon Leonard, Martin Engelhard, Alexander I. Kuklin, Valentin I. Gordeliy
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Two-component systems (TCS) are widespread signaling systems present in all domains of life. TCS typically consist of a signal receptor/transducer and a response regulator. The receptors (histidine kinases, chemoreceptors and photoreceptors)
Externí odkaz:
https://doaj.org/article/3f760df645e345b1a2dd8988f064b12e
Autor:
Philipp S. Orekhov, Marine E. Bozdaganyan, Natalia Voskoboynikova, Armen Y. Mulkidjanian, Maria G. Karlova, Anna Yudenko, Alina Remeeva, Yury L. Ryzhykau, Ivan Gushchin, Valentin I. Gordeliy, Olga S. Sokolova, Heinz-Jürgen Steinhoff, Mikhail P. Kirpichnikov, Konstantin V. Shaitan
Publikováno v:
Nanomaterials, Vol 12, Iss 3, p 361 (2022)
Amphiphilic copolymers consisting of alternating hydrophilic and hydrophobic units account for a major recent methodical breakthrough in the investigations of membrane proteins. Styrene–maleic acid (SMA), diisobutylene–maleic acid (DIBMA), and re
Externí odkaz:
https://doaj.org/article/a167d1deab034ef9be66ba5862c0bb35
Autor:
Marine E. Bozdaganyan, Konstantin V. Shaitan, Mikhail P. Kirpichnikov, Olga S. Sokolova, Philipp S. Orekhov
Publikováno v:
Viruses, Vol 14, Iss 2, p 295 (2022)
Currently, SARS-CoV-2 causing coronavirus disease 2019 (COVID-19) is responsible for one of the most deleterious pandemics of our time. The interaction between the ACE2 receptors at the surface of human cells and the viral Spike (S) protein triggers
Externí odkaz:
https://doaj.org/article/6c7bb4714ac94ce8b0a6012d092ebfeb
Autor:
Vladimir A Fedorov, Philipp S Orekhov, Ekaterina G Kholina, Artem A Zhmurov, Fazoil I Ataullakhanov, Ilya B Kovalenko, Nikita B Gudimchuk
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 8, p e1007327 (2019)
Thirteen tubulin protofilaments, made of αβ-tubulin heterodimers, interact laterally to produce cytoskeletal microtubules. Microtubules exhibit the striking property of dynamic instability, manifested in their intermittent growth and shrinkage at b
Externí odkaz:
https://doaj.org/article/6ab62dfc0b6e4ec8bba75c5d8b8aae38
Autor:
Vladimir A. Fedorov, Philipp S. Orekhov, Ekaterina G. Kholina, Ilya B. Kovalenko, Nikita B. Gudimchuk
Publikováno v:
International Journal of Biomedicine, Vol 9, Iss Suppl_1, Pp S7-S8 (2019)
Background: Tubulin microtubules are essential cytoskeletal filaments, with diverse and critical functions at all stages of the cell cycle. Tubulin dimers, which serve as main building blocks for microtubules, can self-assemble and disassemble, depen
Externí odkaz:
https://doaj.org/article/ce9d3c03ee4b4df2a3c6e9fa175ec1c1
Autor:
Natalia Voskoboynikova, Wageiha Mosslehy, Alexandr Colbasevici, Dmitry V. Bagrov, Philipp S. Orekhov, Marine E. Bozdaganyan, Armen Y. Mulkidjanian, Konstantin V. Shaitan
Publikováno v:
International Journal of Biomedicine, Vol 9, Iss Suppl_1, Pp S21-S21 (2019)
Background: The membrane-embedded 2:2 sensory rhodopsin II/transducer complex, NpSRII/NpHtrII, plays a key role in the photophobic response of the halophilic archaeon Natronomonas pharaonis. Photon absorption induces transient structural changes in t
Externí odkaz:
https://doaj.org/article/026f6bf09e764a83b6581793b8132acc
Autor:
Philipp S. Orekhov
Publikováno v:
International Journal of Biomedicine, Vol 11, Iss Suppl_1, Pp 13-13 (2021)
Background: Despite the advances in computational techniques and computing resources, the atomistic simulations are still limited in terms of attainable simulation time (up to 1-100 μs) and system size (up to millions of atoms). Various coarse-grain
Externí odkaz:
https://doaj.org/article/2ac8c907e2354a95aafce0a5425c1cda
Publikováno v:
Membranes, Vol 11, Iss 6, p 410 (2021)
The search for new formulations for transdermal drug delivery (TDD) is an important field in medicine and cosmetology. Molecules with specific physicochemical properties which can increase the permeability of active ingredients across the stratum cor
Externí odkaz:
https://doaj.org/article/53d395e17d834e4eb445c7a788978281
Publikováno v:
Pharmaceutics, Vol 13, Iss 1, p 66 (2021)
The cutaneous delivery route currently accounts for almost 10% of all administered drugs and it is becoming more common. Chemical penetration enhancers (CPEs) increase the transport of drugs across skin layers by different mechanisms that depend on t
Externí odkaz:
https://doaj.org/article/de8ddb45f24949888baa7286d2c08ff6