Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Philipp Reautschnig"'
Autor:
Karthika Devi Kiran Kumar, Shubhangi Singh, Stella Maria Schmelzle, Paul Vogel, Carolin Fruhner, Alfred Hanswillemenke, Adrian Brun, Jacqueline Wettengel, Yvonne Füll, Lukas Funk, Valentin Mast, J. Josephine Botsch, Philipp Reautschnig, Jin Billy Li, Thorsten Stafforst
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract RNA base editing relies on the introduction of adenosine-to-inosine changes into target RNAs in a highly programmable manner in order to repair disease-causing mutations. Here, we propose that RNA base editing could be broadly applied to per
Externí odkaz:
https://doaj.org/article/724df14e1cb54fe4a6a260b6d4615676
Autor:
Philipp Reautschnig, Nicolai Wahn, Jacqueline Wettengel, Annika E. Schulz, Ngadhnjim Latifi, Paul Vogel, Tae-Won Kang, Laura S. Pfeiffer, Christine Zarges, Ulrike Naumann, Lars Zender, Jin Billy Li, Thorsten Stafforst
Publikováno v:
Nature Biotechnology. 40:759-768
RNA base editing represents a promising alternative to genome editing. Recent approaches harness the endogenous RNA-editing enzyme adenosine deaminase acting on RNA (ADAR) to circumvent problems caused by ectopic expression of engineered editing enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fccc722c72bc8f732617b21e535164a
https://doi.org/10.1038/s41587-021-01105-0
https://doi.org/10.1038/s41587-021-01105-0
Autor:
Andreas Blaha, Tobias Merkle, Qin Li, Philipp Reautschnig, Jacqueline Wettengel, Thorsten Stafforst, Paul Vogel, Jin Billy Li, Sarah Merz
Publikováno v:
Nature Biotechnology. 37:133-138
Site-directed RNA editing might provide a safer or more effective alternative to genome editing in certain clinical scenarios. Until now, RNA editing has relied on overexpression of exogenous RNA editing enzymes or of endogenous human ADAR (adenosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45a1f75874a15ad1f6f5673bee7c1ebd
https://doi.org/10.1038/s41587-019-0013-6
https://doi.org/10.1038/s41587-019-0013-6
Publikováno v:
RNA Biology
mRNA is an attractive drug target for therapeutic interventions. In this review we highlight the current state, clinical trials, and developments in antisense therapy, including the classical approaches like RNaseH-dependent oligomers, splice-switchi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e4835ac5f06ed882ffbda48fe77347
http://europepmc.org/articles/PMC5449091
http://europepmc.org/articles/PMC5449091
Publikováno v:
Genes; Volume 8; Issue 1; Pages: 34
Site-directed RNA editing is an approach to reprogram genetic information at the RNA level. We recently introduced a novel guideRNA that allows for the recruitment of human ADAR2 to manipulate genetic information. Here, we show that the current guide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::85ecf80a8abfde1875a9fc3567045004
Publikováno v:
Genes
Genes, Vol 8, Iss 1, p 34 (2017)
Genes, Vol 8, Iss 1, p 34 (2017)
Site-directed RNA editing is an approach to reprogram genetic information at the RNA level. We recently introduced a novel guideRNA that allows for the recruitment of human ADAR2 to manipulate genetic information. Here, we show that the current guide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::eec3e06a3548bcdbc5b695da848a035a
http://europepmc.org/articles/PMC5295028
http://europepmc.org/articles/PMC5295028
Autor:
Bernd Nürnberg, Benedikt Mothes, Claus-Michael Lehr, Andrea Schams, Michael S. D. Kormann, Lauren Mays, Franziska Zeyer, Alexander Dewerth, Sandra Beer-Hammer, Pacharapan Surapolchai, Mohammed Alkahled, Dominik Hartl, Emad Malaeksefat, Matthias Griese, Philipp Reautschnig, Jennifer Rottenberger, Azita J. Mahiny, Rupert Handgretinger, Melanie Carevic, Brigitta Loretz, Darina M. Brosch, Martina Bakele, Matthias Schwab
Publikováno v:
3.1 Molecular Pathology and Functional Genomics.
Genome editing using site-specific endonucleases (SSE) holds great potential to repair disease-causing genes. In this study we offer a promising approach to deliver SSEs as nuclease-encoded, chemically modified mRNA (nec-mRNA) together with a repair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53b80e7e4d4367d54837b837a53a2af8
https://doi.org/10.1183/13993003.congress-2016.pa889
https://doi.org/10.1183/13993003.congress-2016.pa889
Autor:
Bernd Nürnberg, Alexander Dewerth, Benedikt Mothes, Darina M. Brosch, Andrea Schams, Claus-Michael Lehr, Pacharapan Surapolchai, Lauren Mays, Philipp Reautschnig, Dominik Hartl, Mohammed Alkhaled, Sandra Beer-Hammer, Matthias Griese, Jennifer Rottenberger, Franziska Zeyer, Matthias Schwab, Melanie Carevic, Emad Malaeksefat, Martina Bakele, Brigitta Loretz, Michael S. D. Kormann, Azita J. Mahiny, Rupert Handgretinger
Publikováno v:
Nature Biotechnology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6b2ee754a3d7fddf75e25d23eb903a
https://hdl.handle.net/10033/566264
https://hdl.handle.net/10033/566264
