Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Philipp Rathert"'
Autor:
Franziska Knodel, Jürgen Eirich, Sabine Pinter, Stephan A. Eisler, Iris Finkemeier, Philipp Rathert
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract LSD1 plays a crucial role in mammalian biology, regulated through interactions with coregulators and post-translational modifications. Here we show that the kinase NEK6 stimulates LSD1 activity in cells and observe a strong colocalization of
Externí odkaz:
https://doaj.org/article/8be6f29756834180b53ed5f7ae50b1f9
Autor:
Benoit Toubhans, Nour Alkafri, Marcos Quintela, David W. James, Caroline Bissardon, Salvatore Gazze, Franziska Knodel, Olivier Proux, Alexandra T. Gourlan, Philipp Rathert, Sylvain Bohic, Deyarina Gonzalez, Lewis W. Francis, Laurent Charlet, R. Steven Conlan
Publikováno v:
Redox Biology, Vol 61, Iss , Pp 102641- (2023)
At physiological levels, the trace element selenium plays a key role in redox reactions through the incorporation of selenocysteine in antioxidant enzymes. Selenium has also been evaluated as a potential anti-cancer agent, where selenium nanoparticle
Externí odkaz:
https://doaj.org/article/0d866209360b48c281dc8583dd5dbc1a
Autor:
Jeannine Diesch, Marguerite-Marie Le Pannérer, René Winkler, Raquel Casquero, Matthias Muhar, Mark van der Garde, Michael Maher, Carolina Martínez Herráez, Joan J. Bech-Serra, Michaela Fellner, Philipp Rathert, Nigel Brooks, Lurdes Zamora, Antonio Gentilella, Carolina de la Torre, Johannes Zuber, Katharina S. Götze, Marcus Buschbeck
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Azacitidine (AZA) treatment is used for patients with myelodysplasias that cannot undergo bone marrow transplantation; however, AZA treatment is only partially effective. Here the authors show synergy of AZA with compounds inhibiting the chromatin re
Externí odkaz:
https://doaj.org/article/d0619bde27374a0bbc9ce933934d9f91
Autor:
Patricia Fraungruber, Till Kaltofen, Sabine Heublein, Christina Kuhn, Doris Mayr, Alexander Burges, Sven Mahner, Philipp Rathert, Udo Jeschke, Fabian Trillsch
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
PurposeWnt pathway modulator Dickkopf 2 (Dkk2) and signaling of the G protein-coupled estrogen receptor (GPER) seem to have essential functions in numerous cancer types. For epithelial ovarian cancer (EOC), it has not been proven if either Dkk2 or th
Externí odkaz:
https://doaj.org/article/9496e9134ef94648a9530ce9c331db4b
Autor:
Philipp Rathert
Publikováno v:
Life, Vol 11, Iss 8, p 726 (2021)
NSD3 is one of six H3K36-specific lysine methyltransferases in metazoans, and the methylation of H3K36 is associated with active transcription. NSD3 is a member of the nuclear receptor-binding SET domain (NSD) family of histone methyltransferases tog
Externí odkaz:
https://doaj.org/article/c42d0288aa714386bef73813d5006b6f
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Tools for imaging epigenetic modifications can shed light on the regulation of epigenetic processes. Here, the authors present a fluorescence complementation approach for detection of DNA and histone methylation at endogenous genomic sites allowing f
Externí odkaz:
https://doaj.org/article/e44e3b2e78014a09bf15e0148a8b7e32
Publikováno v:
BioTechniques, Vol 43, Iss 5, Pp 602-608 (2007)
We describe a continuous peptide methylation assay using the Neurospora crassa Dim-5 histone H3 lysine 9 (H3K9) methyltransferase as a model system. The assay uses streptavidin FlashPlates coated with target peptide. Since no washing and pipeting ste
Externí odkaz:
https://doaj.org/article/1ed2ae0de03044e9b97a97e697bdb267
Publikováno v:
Nucleic Acids Research
Chromatin properties are regulated by complex networks of epigenome modifications. Currently, it is unclear how these modifications interact and if they control downstream effects such as gene expression. We employed promiscuous chromatin binding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4bb642cc13960d658b889bf4817780
http://europepmc.org/articles/PMC7797067
http://europepmc.org/articles/PMC7797067
Autor:
Lorena Decker, Patricia Fraungruber, Jan Mueller, Fabian Trillsch, Lewis Francis, Sven Mahner, Philipp Rathert, R. Steven Conlan, Ann-Katrin Loeffler, Sabine Pinter, Stephan A. Eisler, Tabea L. Bauer, Udo Jeschke, Johannes Zuber, Stefan Kommoss, Till Kaltofen, Annette Staebler, Katrin Collmar
Publikováno v:
Cancers
Volume 13
Issue 15
Cancers, Vol 13, Iss 3801, p 3801 (2021)
Volume 13
Issue 15
Cancers, Vol 13, Iss 3801, p 3801 (2021)
Simple Summary Most epithelial ovarian cancer (EOC) patients, although initially responsive to standard treatment with platinum-based chemotherapy, develop platinum resistance over the clinical course and succumb due to drug-resistant metastases. It
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d982252a2d24663935eba7e03ce1164
http://europepmc.org/articles/PMC8345099
http://europepmc.org/articles/PMC8345099
Autor:
Christoph Plass, Pavel Bashtrykov, Michael Dukatz, Philipp Rathert, Stefan Kunert, Annika Baude, Albert Jeltsch, Sabrina Adam, Max Emperle
Publikováno v:
Nucleic Acids Research
Somatic DNMT3A mutations at R882 are frequently observed in AML patients including the very abundant R882H, but also R882C, R882P and R882S. Using deep enzymology, we show here that DNMT3A-R882H has more than 70-fold altered flanking sequence prefere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235bc8911cb79cb85916d6742514bde5
https://doi.org/10.1093/nar/gkz911
https://doi.org/10.1093/nar/gkz911