Site-Specifically-Labeled Antibodies for Super-Resolution Microscopy Reveal

Autor: Susanna M, Früh, Ulf, Matti, Philipp R, Spycher, Marina, Rubini, Sebastian, Lickert, Thomas, Schlichthaerle, Ralf, Jungmann, Viola, Vogel, Jonas, Ries, Ingmar, Schoen

Publikováno v: ACS Nano

The precise spatial localization of proteins in situ by super-resolution microscopy (SRM) demands their targeted labeling. Positioning reporter molecules as close as possible to the target remains a challenge in primary cells or tissues from patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::046655d0850149f698a24c1c35dad44a
https://pubmed.ncbi.nlm.nih.gov/34184536

Towards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo

Autor: Mikael Jensen, Matthias Gunzer, Philipp R. Spycher, Djamschid Solouk-Saran, Christopher R. Thornton, Mike Hasenberg, Martin Eichner, Bernd J. Pichler, Lauren S. Ryder, Anna-Maria Rolle, Stefan Wiehr, Jesper Fonslet, Adrien Dubois, Roger Schibli, Frédéric Boschetti, Genna Davies, Franck Denat, Claudia Schillinger, Andreas Maurer, Juliane Weski

Publikováno v: Theranostics
Theranostics, Ivyspring International Publisher, 2017, 7 (14), pp.3398-3414. 〈http://www.thno.org/v07p3398.htm〉. 〈10.7150/thno.20919〉
Davies, G, Rolle, A-M, Maurer, A, Spycher, P R, Schillinger, C, Solouk-Saran, D, Hasenberg, M, Weski, J, Fonslet, J, Dubois, A, Boschetti, F, Denat, F, Gunzer, M, Eichner, M, Ryder, L S, Jensen, M, Schibli, R, Pichler, B J, Wiehr, S & Thornton, C R 2017, ' Towards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo ', Theranostics, vol. 7, no. 14, pp. 3398-3414 . https://doi.org/10.7150/thno.20919
Theranostics, 7 (14)
Theranostics, Ivyspring International Publisher, 2017, 7 (14), pp.3398-3414. ⟨10.7150/thno.20919⟩

Invasive pulmonary aspergillosis (IPA) is a life-threatening lung disease of hematological malignancy or bone marrow transplant patients caused by the ubiquitous environmental fungus Aspergillus fumigatus. Current diagnostic tests for the disease lac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11534a76147f07784219110c83f668b7
http://europepmc.org/articles/PMC5596432

Microbial Transglutaminase and c-myc-Tag: A Strong Couple for the Functionalization of Antibody-Like Protein Scaffolds from Discovery Platforms

Autor: Patrick Dennler, Eliane Fischer, Laura K. Bailey, Roger Schibli, Philipp R. Spycher

Publikováno v: Chembiochem : a European journal of chemical biology

Antibody-like proteins selected from discovery platforms are preferentially functionalized by site-specific modification as this approach preserves the binding abilities and allows a side-by-side comparison of multiple conjugates. Here we present an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5372ba8e097f4bc0fe56c2a4f91f25ff
https://doi.org/10.1002/cbic.201500009

Functional Modification of Fibronectin by N-Terminal FXIIIa-Mediated Transamidation

Autor: Susanna M. Früh, Melanie A. Burkhardt, Maria Mitsi, Philipp R. Spycher, Ingmar Schoen, Viola Vogel

Publikováno v: ChemBioChem

A straightforward strategy is presented for the site-specific incorporation of fluorophores or reactive probes into the extracellular matrix (ECM) protein fibronectin (Fn) by using the enzyme-catalyzed transamidation by activated factor XIII. Charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c503cf08317d9a597b5dc3297809bd53
https://doi.org/10.1002/cbic.201402099

ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo

Autor: Bernd J. Pichler, Andreas Maurer, Juliane Weski, Philipp R. Spycher, Djamschid Solouk-Saran, Genna Davies, Anna-Maria Rolle, Frédéric Boschetti, Stella E. Autenrieth, Linda Männ, Sven Krappmann, Dunja Bruder, Sabine Stegemann-Koniszewski, Matthias Gunzer, Christopher R. Thornton, Eliane Fischer, Gregory Severin, Mike Hasenberg, Stefan Wiehr, Roger Schibli

Publikováno v: Rolle, A-M, Hasenberg, M, Thornton, C R, Solouk-Saran, D, Mann, L, Weski, J, Maurer, A, Fischer, E, Spycher, P R, Schibli, R, Boschetti, F, Stegemann-Koniszewski, S, Bruder, D, Severin, G W, Autenrieth, S E, Krappmann, S, Davies, G, Pichler, B J, Gunzer, M & Wiehr, S 2016, ' Immuno PET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo ', Proceedings of the National Academy of Sciences, vol. 113, no. 8, pp. E1026-E1033 . https://doi.org/10.1073/pnas.1518836113

Invasive pulmonary aspergillosis (IPA) is a life-threatening lung disease caused by the fungus Aspergillus fumigatus, and is a leading cause of invasive fungal infection-related mortality and morbidity in patients with hematological malignancies and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad29ea543c343f43908e2354f667f82e