Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Philipp Penninger"'
Autor:
Philipp Penninger, Helena Brezovec, Irina Tsymala, Magdalena Teufl, Trinh Phan-Canh, Tamires Bitencourt, Marie Brinkmann, Walter Glaser, Wilfried Ellmeier, Michael Bonelli, Karl Kuchler
Publikováno v:
Cell Reports, Vol 43, Iss 12, Pp 114993- (2024)
Summary: Histone deacetylases (HDACs) contribute to shaping many aspects of T cell lineage functions in anti-infective surveillance; however, their role in fungus-specific immune responses remains poorly understood. Using a T cell-specific deletion o
Externí odkaz:
https://doaj.org/article/f28f3f111aae4ea7a61d8ea5f2b710a6
Autor:
Sabrina Jenull, Raju Shivarathri, Irina Tsymala, Philipp Penninger, Phan-Canh Trinh, Filomena Nogueira, Manju Chauhan, Ashutosh Singh, Andriy Petryshyn, Anton Stoiber, Anuradha Chowdhary, Neeraj Chauhan, Karl Kuchler
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Candida auris emerged as a human fungal pathogen only during the past decade. Remarkably, C. auris displays high degrees of genomic diversity and phenotypic plasticity, with four major clades causing hospital outbreaks with high mortality an
Externí odkaz:
https://doaj.org/article/980b967c8cbb4a20909c22e11eba9400
Autor:
Philipp Penninger, Michael Riedelberger, Irina Tsymala, Hossein Arzani, Sabrina Jenull, Karl Kuchler
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100352- (2021)
Summary: Zinc (Zn2+) is a trace element, playing pivotal roles during host-pathogen interactions. Macrophages can sequester Zn2+ and restrict bioavailability or increase phagolysosomal Zn2+ to kill pathogens. This method quantifies Zn2+-mediated clea
Externí odkaz:
https://doaj.org/article/95fa5486f08449aaad0e80dbe5f33191
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Candida albicans is an opportunistic human fungal pathogen that relies upon different virulence traits, including morphogenesis, invasion, biofilm formation, and nutrient acquisition from host sources as well as metabolic adaptations during host inva
Externí odkaz:
https://doaj.org/article/1d5ad1a4d07846c69dc31faf6c5141ae
Autor:
Michael Riedelberger, Philipp Penninger, Michael Tscherner, Bernhard Hadriga, Carina Brunnhofer, Sabrina Jenull, Anton Stoiber, Christelle Bourgeois, Andriy Petryshyn, Walter Glaser, Andreas Limbeck, Michael A. Lynes, Gernot Schabbauer, Guenter Weiss, Karl Kuchler
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Host and fungal pathogens compete for metal ion acquisition during infectious processes, but molecular mechanisms remain largely unknown. Here, we show that type I interferons (IFNs-I) dysregulate zinc homeostasis in macrophages, which emplo
Externí odkaz:
https://doaj.org/article/20189ec086c24357bfbc0929fda069b3
Autor:
Michael Riedelberger, Irina Tsymala, Sabrina Jenull, Philipp Penninger, Karl Kuchler, Hossein Arzani
Publikováno v:
STAR Protocols
STAR Protocols, Vol 2, Iss 1, Pp 100352-(2021)
STAR Protocols, Vol 2, Iss 1, Pp 100352-(2021)
Summary Zinc (Zn2+) is a trace element, playing pivotal roles during host-pathogen interactions. Macrophages can sequester Zn2+ and restrict bioavailability or increase phagolysosomal Zn2+ to kill pathogens. This method quantifies Zn2+-mediated clear
Autor:
Andriy Petryshyn, Sabrina Jenull, Michael Tscherner, Lucia F. Zacchi, Fitz Gerald S. Silao, Michael Riedelberger, Philipp Penninger, Raju Shivarathri, Per O. Ljungdahl, Salomé Leibund Gut Landmann, Florian Zwolanek, Neeraj Chauhan, Kontxi Martinez de San Vicente, Karl Kuchler, Naga C. Bandari, Theresia Mair
Publikováno v:
Cell reports
SUMMARY Adaptation to changing environments and immune evasion is pivotal for fitness of pathogens. Yet, the underlying mechanisms remain largely unknown. Adaptation is governed by dynamic transcriptional re-programming, which is tightly connected to
Autor:
Bernhard Hadriga, Andriy Petryshyn, Anton Stoiber, Walter Glaser, Michael A. Lynes, Sabrina Jenull, Michael Riedelberger, Andreas Limbeck, Carina Brunnhofer, Karl Kuchler, Guenter Weiss, Philipp Penninger, Christelle Bourgeois, Gernot Schabbauer, Michael Tscherner
Publikováno v:
iScience
iScience, Vol 23, Iss 5, Pp-(2020)
iScience, Vol 23, Iss 5, Pp-(2020)
Summary Host and fungal pathogens compete for metal ion acquisition during infectious processes, but molecular mechanisms remain largely unknown. Here, we show that type I interferons (IFNs-I) dysregulate zinc homeostasis in macrophages, which employ
Autor:
Birgit Strobl, Andreas Limbeck, Sabrina Jenull, Bernhard Scheidl, Irina Tsymala, Andriy Petryshyn, Markus Seifert, Guenter Weiss, Carina Brunnhofer, Karl Kuchler, Walter Glaser, Christelle Bourgeois, Philipp Penninger, Michael Tscherner, Michael Riedelberger
Publikováno v:
Cell Host & Microbe. 27:454-466.e8
Summary Type I interferons (IFNs-I) fulfil multiple protective functions during pathogenic infections, but they can also cause detrimental effects and enhance immunopathology. Here, we report that IFNs-I promote the dysregulation of iron homeostasis