Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Philipp Nawrath"'
Autor:
Lena Jaki, Sebastian Weigang, Lisa Kern, Stefanie Kramme, Antoni G. Wrobel, Andrea B. Grawitz, Philipp Nawrath, Stephen R. Martin, Theo Dähne, Julius Beer, Miriam Disch, Philipp Kolb, Lisa Gutbrod, Sandra Reuter, Klaus Warnatz, Martin Schwemmle, Steven J. Gamblin, Elke Neumann-Haefelin, Daniel Schnepf, Thomas Welte, Georg Kochs, Daniela Huzly, Marcus Panning, Jonas Fuchs
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Monoclonal antibodies (mAbs) directed against the spike of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are effective therapeutic options to combat infections in high-risk patients. Here, we report the adaptation of SARS-CoV-
Externí odkaz:
https://doaj.org/article/d61edc8bae2d4d3c8f29f4fd3b6b89ba
Autor:
Edgar Gonzalez-Rodriguez, Mia Zol-Hanlon, Ganka Bineva-Todd, Andrea Marchesi, Mark Skehel, Keira E. Mahoney, Chloë Roustan, Annabel Borg, Lucia Di Vagno, Svend Kjaer, Antoni G. Wrobel, Donald J. Benton, Philipp Nawrath, Sabine L. Flitsch, Dhira Joshi, Andrés Manuel González-Ramírez, Katalin A. Wilkinson, Robert J. Wilkinson, Emma C. Wall, Ramón Hurtado-Guerrero, Stacy A. Malaker, Benjamin Schumann
Publikováno v:
Gonzalez-Rodriguez, E, Zol-Hanlon, M, Bineva-Todd, G, Marchesi, A, Skehel, M, Mahoney, K E, Roustan, C, Borg, A, Di Vagno, L, Kjær, S, Wrobel, A G, Benton, D J, Nawrath, P, Flitsch, S L, Joshi, D, González-Ramírez, A M, Wilkinson, K A, Wilkinson, R J, Wall, E C, Hurtado-Guerrero, R, Malaker, S A & Schumann, B 2023, ' O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern ', ACS Central Science, vol. 9, no. 3, pp. 393-404 . https://doi.org/10.1021/acscentsci.2c01349
The emergence of a polybasic cleavage motif for the protease furin in the SARS-CoV-2 spike protein has been established as a major factor for enhanced viral transmission in humans. The peptide region N-terminal to that motif is extensively mutated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8375bb070568530844a5ff77444ebaee
Autor:
Gitta Anne Heinz, Josefine Radke, Sophie Mc Ewen, V. Moos, Jobst Roehmel, Tilmann Kallinich, Pawel Durek, Daniela Niemeyer, Leif G. Hanitsch, Florian Kurth, Thordis Hohnstein, Uwe Kölsch, Mario Witkowski, Philipp Nawrath, Marcus A. Mall, Frederik Heinrich, Leif E. Sander, Stefan Frischbutter, Mir-Farzin Mashreghi, Tom Aschman, Emanuela Marcenaro, Victor M. Corman, Edoardo Viviano, Sascha Treskatsch, Andreas Diefenbach, Marta Ferreira-Gomes, Marcus Maurer, Christian Meisel, Caroline Tizian, Robert Lorenz Chua, Claudia U. Duerr, Stefan Angermair, Andrey Kruglov, Helena Radbruch, Birgit Sawitzki, Silvia Zocche, Christian Conrad, Andreas Radbruch, Irene Mattiola, Joseph A. Trapani, Thomas Schneider, Christian Drosten, Terry Jones, Kristina Allers
Publikováno v:
Nature. 600:295-301
SARS-CoV-2 is a single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Given its acute and often self-limiting course, components of the innate immune system are likely central in controlling virus replication thereby determining
Autor:
Antoni G. Wrobel, Philipp Nawrath
Publikováno v:
Structure (London, England : 1993). 30(10)
In this issue of Structure, Lan and colleagues seek to identify regions on the ACE2 receptor and coronavirus spikes that are essential for the viral attachment. They achieve it through a detailed comparative analysis of the binding of coronaviruses N