Cascade Biotransformation to Access 3‐Methylpiperidine in Whole Cells

Autor: Lars Lauterbach, Niels Borlinghaus, Bettina M. Nestl, Bernhard Hauer, Anne-Sophie Coquel, Claus Lattemann, Leonie Weinmann, Philipp N. Scheller, Florian Krimpzer, Ammar Al-Shameri

Publikováno v: ChemCatChem. 11:5738-5742

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28ee1640bde853897893fe3a2b69392a
https://doi.org/10.1002/cctc.201900702

Cultivation and purification of two stereoselective imine reductases from Streptosporangium roseum and Paenibacillus elgii

Autor: Sven M. Richter, Philipp N. Scheller, Bettina M. Nestl, Maike Lenz, Bernhard Hauer

Publikováno v: Protein Expression and Purification. 133:199-204

The reductive amination is one of the most important reactions in the synthesis of chiral amines. Imine reductases (IREDs) are novel enzymes that catalyze the asymmetric reduction of imines and reductive aminations using NADPH as hydride donor. In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddb0929c4a629d468e6ff53531c2d8e
https://doi.org/10.1016/j.pep.2016.05.003

Identification of imine reductase-specific sequence motifs

Autor: Silvia, Fademrecht, Philipp N, Scheller, Bettina M, Nestl, Bernhard, Hauer, Jürgen, Pleiss

Publikováno v: Proteins. 84(5)

Chiral amines are valuable building blocks for the production of a variety of pharmaceuticals, agrochemicals and other specialty chemicals. Only recently, imine reductases (IREDs) were discovered which catalyze the stereoselective reduction of imines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a98b997a9735e9ccd015c913e1e3875
https://pubmed.ncbi.nlm.nih.gov/26857686

Enzyme toolbox: novel enantiocomplementary imine reductases

Autor: Philipp N. Scheller, Bernhard Hauer, Nicholas J. Turner, Jürgen Pleiss, Friedemann Leipold, Silvia Fademrecht, Sebastian Hofelzer, Bettina M. Nestl

Publikováno v: Scheller, P N, Fademrecht, S, Hofelzer, S, Pleiss, J, Leipold, F, Turner, N, Nestl, B & Hauer, B 2014, ' Enzyme Toolbox: Novel Enantiocomplementary Imine Reductases ', CHEMBIOCHEM, vol. 15, no. 15, pp. 2201-2204 . https://doi.org/10.1002/cbic.201402213

Reducing reactions are among the most useful transformations for the generation of chiral compounds in the fine-chemical industry. Because of their exquisite selectivities, enzymatic approaches have emerged as the method of choice for the reduction o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fcae4fec17c8b42f812080648e6f415
https://pubmed.ncbi.nlm.nih.gov/25163890