Fetal hemoglobin induction during decitabine treatment of elderly patients with high-risk myelodysplastic syndrome or acute myeloid leukemia: a potential dynamic biomarker of outcome

Autor: Julia Stomper, Gabriele Ihorst, Stefan Suciu, Philipp N. Sander, Heiko Becker, Pierre W. Wijermans, Christoph Plass, Dieter Weichenhan, Emmanuel Bissé, Rainer Claus, Michael Lübbert

Publikováno v: Haematologica, Vol 104, Iss 1 (2019)

Hematologic responses to hypomethylating agents are often delayed in patients with myelodysplastic syndrome or acute myeloid leukemia. Fetal hemoglobin is a potential novel bio-marker of response: recently, we demonstrated that a high fetal hemoglobi

Externí odkaz: https://doaj.org/article/fb019199e4da4c17bf417769500be575

A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer

Autor: Jae Wook Lee, Paul S. Mischel, Stephen Skirboll, Natasha C. Lucki, Luke L. Lairson, Heiko Wurdak, Kevin Johnson, Brittney A. Beyer, Philipp N. Sander, Genaro R. Villa, Naja Vergani, Peter G. Schultz, Stephan H. Spangenberg, Perry Gordon, Michael J. Bollong, Emily N. Chin, Amandeep Sharma, Justin L. Anglin

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 13
Proceedings of the National Academy of Sciences of the United States of America

Significance We have completed a screen of ∼106 small molecules to identify compounds that induce cell death in multipotent glioblastoma multiforme (GBM) cancer stem cells (CSCs). This resulted in the identification of a hit class (RIPGBM) that was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27327ca5e9255a5143893ff0a327f8dd
https://doi.org/10.1073/pnas.1816626116

Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma

Autor: Daniel Haldar, Justin L. Anglin, Reza Beheshti Zavareh, Costas A. Lyssiotis, Alec C. Kimmelman, Philipp N. Sander, Luke L. Lairson, Lewis C. Cantley, Edouard Mullarky

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 28:2675-2678

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is extremely refractory to the therapeutic approaches that have been evaluated to date. Recently, it has been demonstrated that PDAC tumors are dependent upon a metabolic pathway inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1a04df638737d00f17551697fa493e
https://doi.org/10.1016/j.bmcl.2018.04.061

Dinosaur origin of egg color: oviraptors laid blue-green eggs

Autor: P. Martin Sander, Marianne Engeser, Stephanie Kath-Schorr, Christa E. Müller, Jasmina Wiemann, Philipp N. Sander, Marion Schneider, Tzu-Ruei Yang

Publikováno v: PeerJ, Vol 5, p e3706 (2017)
PeerJ

Protoporphyrin (PP) and biliverdin (BV) give rise to the enormous diversity in avian egg coloration. Egg color serves several ecological purposes, including post-mating signaling and camouflage. Egg camouflage represents a major character of open-nes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceae8146431f5f9ab70159769ff28c9b
https://peerj.com/articles/3706.pdf

Azanucleoside DNA Methyltransferase Inhibitor Drugs: Update on Clinical Applications in Myelodysplastic Syndromes and Acute Myeloid Leukemia

Autor: Michael Lübbert, Michael Daskalakis, Andrea Kündgen, Philipp N. Sander

Publikováno v: Epigenetics-A Different Way of Looking at Genetics ISBN: 9783319271842

The cytidine analog 5-azacytidine (5-aza, Vidaza) and its deoxyribonucleoside analog 5-aza-2′-deoxycytidine (decitabine, Dacogen), while first synthesized and shown to have interesting antileukemic activity in 1964, have only recently been FDA and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e92a468080f3f9336fe811bcfba83ec
https://doi.org/10.1007/978-3-319-27186-6_10