Sliding over the blocks in enzyme-free RNA copying--one-pot primer extension in ice.

Autor: Philipp M G Löffler, Joost Groen, Mark Dörr, Pierre-Alain Monnard

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e75617 (2013)

Template-directed polymerization of RNA in the absence of enzymes is the basis for an information transfer in the 'RNA-world' hypothesis and in novel nucleic acid based technology. Previous investigations established that only cytidine rich strands a

Externí odkaz: https://doaj.org/article/4e4e878a9d7a406dbcca07a1373bce5e

Targeting SARS-CoV-2 spike protein by stapled hACE2 peptides

Autor: Jasmin Mecinović, Philipp M. G. Löffler, Jordi C. J. Hintzen, Marijn N. Maas

Publikováno v: Maas, M N, Hintzen, J C J, Löffler, P M G & Mecinović, J 2021, ' Targeting SARS-CoV-2 spike protein by stapled hACE2 peptides ', Chemical Communications, vol. 57, no. 26, pp. 3283-3286 . https://doi.org/10.1039/D0CC08387A
Chemical Communications

SARS-CoV-2 Spike protein RBD interacts with the hACE2 receptor toinitiate cell entry and infection. We set out to develop lactam-based i,i + 4 stapled hACE2 peptides targeting SARS-CoV-2. In vitro screeningdemonstrates the inhibition of the Spike pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a869258b8ea469d2d828d6d6f80b20
https://findresearcher.sdu.dk:8443/ws/files/181415715/d0cc08387a.pdf

DNA-Mediated Liposome Fusion Observed by Fluorescence Spectrometry

Autor: Oliver Ries, Stefan Vogel, Philipp M. G. Löffler

Publikováno v: Löffler, P M G, Ries, O & Vogel, S 2020, DNA-Mediated Liposome Fusion Observed by Fluorescence Spectrometry . in K Astakhova & S A Bukhari (eds), Nucleic Acid Detection and Structural Investigations : Methods and Protocols . vol. 2063, Humana Press, Methods in Molecular Biology, vol. 2063, pp. 101-118 . https://doi.org/10.1007/978-1-0716-0138-9_9
Methods in Molecular Biology ISBN: 9781071601372

DNA-programmed and controlled fusion of lipid membranes have recently been optimized to reliably mix the contents between two populations of liposomes, each functionalized with complementary lipidated DNA (LiNA) oligomer. In this chapter we describe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e327b03160dfaadac5ad23a4006bedd3
https://portal.findresearcher.sdu.dk/da/publications/4ee25a58-81ad-481a-b0ec-9dbab2ca0693

Ethyl 2-(1,2,3,4-tetrahydrospiro[carbazole-3,2′-[1,3]dioxolan]-9-yl)acetate

Autor: Philipp M. G. Löffler, Trond Ulven, Andrew D. Bond

Publikováno v: Acta Crystallographica Section E, Vol 65, Iss 4, Pp o685-o685 (2009)

In the title compound, C18H21NO4, the hydrogenated six-membered ring of the carbazole unit adopts a half-chair conformation. The dioxolane ring and ethylacetate substituent point to opposite sides of the carbazole plane. The ethylacetate substituent

Externí odkaz: https://doaj.org/article/1fb543ec031443289134869384c4d03c

Fusion von Liposomen in einer DNA‐programmierten Kaskade

Autor: Rasmus P. Thomsen, Stefan Vogel, Oliver Ries, Anders H. Okholm, Alexander Rabe, Philipp M. G. Löffler, Jørgen Kjems

Publikováno v: Löffler, P M G, Ries, O, Rabe, A, Okholm, A H, Thomsen, R P, Kjems, J & Vogel, S 2017, ' A DNA-programmed liposome fusion cascade ', Angewandte Chemie International Edition, vol. 56, no. 43, pp. 13228–13231 . https://doi.org/10.1002/anie.201703243
Löffler, P M G, Ries, O, Rabe, A, Okholm, A H, Thomsen, R P, Kjems, J & Vogel, S 2017, ' Fusion von Liposomen in einer DNA-programmierten Kaskade ', Angewandte Chemie, bind 129, nr. 43, s. 13410-13414 . https://doi.org/10.1002/ange.201703243

Chemically engineered and functionalized nanoscale compartments are used in bottom-up synthetic biology to construct compartmentalized chemical processes. Progressively more complex designs demand spatial and temporal control over entrapped species.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedad98bdb9126d9a100a67bc49a91e2
https://doi.org/10.1002/anie.201703243