Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Philipp Linning"'
Autor:
Philipp Spitzer, Matthias Walter, Caroline Göth, Timo Jan Oberstein, Philipp Linning, Hans-Joachim Knölker, Johannes Kornhuber, Juan Manuel Maler
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
It has been previously shown that the amyloid precursor protein (APP) support the innate immune defense as an immune receptor. Amyloid β (Aβ) peptides seem to have properties of an antimicrobial peptide and can act as opsonines. In APP-deficient mo
Externí odkaz:
https://doaj.org/article/0e37a06f21524da1b433f46479b2637c
Autor:
Timo Jan Oberstein, Philipp Spitzer, Hans-Wolfgang Klafki, Philipp Linning, Florian Neff, Hans-Joachim Knölker, Piotr Lewczuk, Jens Wiltfang, Johannes Kornhuber, Juan Manuel Maler
Publikováno v:
Neurobiology of Disease, Vol 73, Iss , Pp 24-35 (2015)
The neuropathological hallmarks of Alzheimer's disease include extracellular neuritic plaques and neurofibrillary tangles. The neuritic plaques contain β-amyloid peptides (Aβ peptides) as the major proteinaceous constituent and are surrounded by ac
Externí odkaz:
https://doaj.org/article/716113bc60174697895a62fcb024bb73
Autor:
Timo Jan Oberstein, Johannes Kornhuber, Caroline Göth, Philipp Linning, Juan Manuel Maler, Matthias Walter, Philipp Spitzer, Hans-Joachim Knölker
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
It has been previously shown that the amyloid precursor protein (APP) support the innate immune defense as an immune receptor. Amyloid β (Aβ) peptides seem to have properties of an antimicrobial peptide and can act as opsonines. In APP-deficient mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d3ab883047265c0ec9018eeae68c2b
https://opus4.kobv.de/opus4-fau/files/14528/Image_1.tif
https://opus4.kobv.de/opus4-fau/files/14528/Image_1.tif
Autor:
Philipp Spitzer, Matthias Walter, Caroline Kranig, Timo Jan Oberstein, Philipp Linning, Hans-Joachim Knölker, Johannes Kornhuber, Juan Manuel Maler
Background The amyloid precursor protein (APP) and amyloid β (Aβ) peptides support the innate immune defense as an immune receptor, an antimicrobial peptide and an opsonine. In APP-deficient mouse models, a reduced secretion of cytokines has been o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03121b37de04ce3706b7d27ed7f04f4e
https://doi.org/10.21203/rs.2.17045/v1
https://doi.org/10.21203/rs.2.17045/v1
Autor:
Hans-Joachim Knölker, Juan Manuel Maler, Philipp Spitzer, Philipp Linning, Florian Neff, Jens Wiltfang, Piotr Lewczuk, Hans-Wolfgang Klafki, Timo Jan Oberstein, Johannes Kornhuber
Publikováno v:
Neurobiology of Disease, Vol 73, Iss, Pp 24-35 (2015)
The neuropathological hallmarks of Alzheimer's disease include extracellular neuritic plaques and neurofibrillary tangles. The neuritic plaques contain β-amyloid peptides (Aβ peptides) as the major proteinaceous constituent and are surrounded by ac
Autor:
Harry Twaalfhoven, Philip Scheltens, Eugeen Vanmechelen, Hanne Struyfs, Linda J C van Waalwijk van Doorn, Charlotte E. Teunissen, Marleen J.A. Koel-Simmelink, Philipp Linning, H. Bea Kuiperij, Hans Klafki, Hans-Joachim Knölker, Sebastiaan Engelborghs, Marcel M. Verbeek, Jens Wiltfang, Ute Haußmann
Publikováno v:
van Doorn, L J C V W, Koel-Simmelink, M J, Haussmann, U, Klafki, H, Struyfs, H, Linning, P, Knoelker, H-J, Twaalfhoven, H A M, Kuiperij, H B, Engelborghs, S, Scheltens, P, Verbeek, M M, Vanmechelen, E, Wiltfang, J & Teunissen, C E 2016, ' Validation of soluble amyloid-precursor protein assays as diagnostic CSF biomarkers for neurodegenerative diseases ', Journal of Neurochemistry, vol. 137, no. 1, pp. 112-121 . https://doi.org/10.1111/jnc.13527
Journal of Neurochemistry, 137, 1, pp. 112-21
Journal of Neurochemistry, 137, 112-21
Journal of Neurochemistry, 137(1), 112-121. Wiley-Blackwell
Journal of Neurochemistry, 137, 1, pp. 112-21
Journal of Neurochemistry, 137, 112-21
Journal of Neurochemistry, 137(1), 112-121. Wiley-Blackwell
Contains fulltext : 168259.pdf (Publisher’s version ) (Closed access) Analytical validation of a biomarker assay is essential before implementation in clinical practice can occur. In this study, we analytically validated the performance of assays d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdfadce85e2f33c4b2269c29dc3eeddc
https://www.ncbi.nlm.nih.gov/pubmed/26748905
https://www.ncbi.nlm.nih.gov/pubmed/26748905
Autor:
Georg Schlechtingen, Margit Gruner, Hans-Joachim Knölker, Gary Jennings, Sebastian Weidlich, Heinke Schieb, Hans-Wolfgang Klafki, Jens Wiltfang, Philipp Linning
Publikováno v:
Chemistry - A European Journal. 16:14412-14423
Covalent coupling of β-secretase inhibitors to a raftophilic lipid anchor via a suitable spacer by using solid-phase peptide synthesis leads to tripartite structures displaying substantially improved inhibition of cellular secretion of the β-amyloi
Autor:
Marleen J.A. Koel-Simmelink, Linda J C van Waalwijk van Doorn, Hans Klafki, Charlotte E. Teunissen, Hans‐Joachim Knoelker, Marcel M. Verbeek, Hanne Struyfs, Sebastiaan Engelborghs, Philipp Linning, H. Bea Kuiperij, Ute Haußmann, Jens Wiltfang, Eugeen Vanmechelen, Harry Twaalfhoven
Publikováno v:
Alzheimer's & Dementia. 11
Autor:
Olaf Jahn, Thomas Liepold, Johannes Schuchhardt, Christin Janßen, Ute Haußmann, Henrik Zetterberg, Erik Portelius, Philipp Linning, Christopher F. Bauer, Jens Wiltfang, Hans Klafki, Hans-Joachim Knölker
Publikováno v:
Analytical chemistry. 85(17)
Here we present a novel assay for the separation and detection of amino-terminal amyloid-β (Aβ) peptide variants by capillary isoelectric focusing (CIEF) immunoassay. Specific amino-terminally truncated Aβ peptides appear to be generated by β-sec
Autor:
Hans-Wolfgang Klafki, Ute Haussmann, Isaak Beyer, Sebastian Weidlich, Heinke Schieb, Philipp Linning, Hans-Joachim Knölker, Jens Wiltfang
Publikováno v:
Organic & biomolecular chemistry 2012;10:8216–8235, ISSN: 1477-0520
Systematic variation of membrane anchor, spacer and pharmacophore building blocks leads to an optimisation of the inhibitory effect of tripartite structures towards BACE1-induced cleavage of the amyloid precursor protein (APP). Dieser Beitrag ist mit