Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Philipp Leippe"'
Autor:
Daniela Digles, Alvaro Ingles-Prieto, Vojtech Dvorak, Tamara A. M. Mocking, Ulrich Goldmann, Andrea Garofoli, Evert J. Homan, Alberto Di Silvio, Lucia Azzollini, Francesca Sassone, Mario Fogazza, Felix Bärenz, Antje Pommereau, Yasmin Zuschlag, Jasper F. Ooms, Jeppe Tranberg-Jensen, Jesper S. Hansen, Josefina Stanka, Hubert J. Sijben, Helena Batoulis, Eckhard Bender, Riccardo Martini, Adriaan P. IJzerman, David B. Sauer, Laura H. Heitman, Vania Manolova, Juergen Reinhardt, Alexander Ehrmann, Philipp Leippe, Gerhard F. Ecker, Kilian V. M. Huber, Thomas Licher, Lia Scarabottolo, Tabea Wiedmer, Giulio Superti-Furga
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
With over 450 genes, solute carriers (SLCs) constitute the largest transporter superfamily responsible for the uptake and efflux of nutrients, metabolites, and xenobiotics in human cells. SLCs are associated with a wide variety of human diseases, inc
Externí odkaz:
https://doaj.org/article/d3ca8f18dbc2476ea3722a966b570ca6
Autor:
Vojtech Dvorak, Tabea Wiedmer, Alvaro Ingles-Prieto, Patrick Altermatt, Helena Batoulis, Felix Bärenz, Eckhard Bender, Daniela Digles, Franz Dürrenberger, Laura H. Heitman, Adriaan P. IJzerman, Douglas B. Kell, Stefanie Kickinger, Daniel Körzö, Philipp Leippe, Thomas Licher, Vania Manolova, Riccardo Rizzetto, Francesca Sassone, Lia Scarabottolo, Avner Schlessinger, Vanessa Schneider, Hubert J. Sijben, Anna-Lena Steck, Hanna Sundström, Sara Tremolada, Maria Wilhelm, Marina Wright Muelas, Diana Zindel, Claire M. Steppan, Giulio Superti-Furga
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The solute carrier (SLC) superfamily represents the biggest family of transporters with important roles in health and disease. Despite being attractive and druggable targets, the majority of SLCs remains understudied. One major hurdle in research on
Externí odkaz:
https://doaj.org/article/57add1b341ee425fb3b53addb4c3b962
Autor:
Tom Podewin, Julia Ast, Johannes Broichhagen, Nicholas H. F. Fine, Daniela Nasteska, Philipp Leippe, Manuel Gailer, Teresa Buenaventura, Nisha Kanda, Ben J. Jones, Celine M’Kadmi, Jean-Louis Baneres, Jacky Marie, Alejandra Tomas, Dirk Trauner, Anja Hoffmann-Röder, David J. Hodson
Publikováno v:
ACS Central Science, Vol 4, Iss 2, Pp 166-179 (2018)
Externí odkaz:
https://doaj.org/article/f8c0f33ccd2442baa687d32ec11cefda
Autor:
Johannes Broichhagen, Arunas Damijonaitis, Joshua Levitz, Kevin R. Sokol, Philipp Leippe, David Konrad, Ehud Y. Isacoff, Dirk Trauner
Publikováno v:
ACS Central Science, Vol 1, Iss 7, Pp 383-393 (2015)
Externí odkaz:
https://doaj.org/article/5790bcb39b94428ab7da13d91bc40087
Autor:
Lars Hellweg, Martin Pfeifer, Lena Chang, Miroslaw Tarnawski, Andrea Bergner, Jana Kress, Julien Hiblot, Jürgen Reinhardt, Kai Johnsson, Philipp Leippe
Aspartate is a limiting metabolite in proliferating cells with its production closely linked to glutamine and mitochondrial metabolism. To date, measuring aspartate concentrations in live cells was deemed impossible. We present iAspSnFR, a geneticall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfe33826832d0918fa059a6a40fc8fd2
https://doi.org/10.1101/2023.05.04.537313
https://doi.org/10.1101/2023.05.04.537313
Autor:
Erick Carreira, Miroslav Kosar, David Sykes, Alexander Viray, Rosa Maria Vitale, Roman Sarott, Rudolf Ganzoni, David Onion, Janelle Tobias, Philipp Leippe, Christoph Ullmer, Elisabeth Zirwes, Wolfgang Guba, Uwe Grether, James Frank, Dmitry Veprintsev
Pharmacological modulation of cannabinoid receptor type 2 (CB2R) holds promise for the treatment of neuroinflammatory disorders, such as Alzheimer’s disease. Despite the importance of CB2R, its expression and downstream signaling are insufficiently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a19f0c420996c76e9ef0d54343b7b00e
https://doi.org/10.26434/chemrxiv-2022-z58fd
https://doi.org/10.26434/chemrxiv-2022-z58fd
Autor:
Katia Cailliau, Dirk Trauner, Alexandra Mougel, Colette Dissous, Johannes Broichhagen, Philipp Leippe, Marion Morel, Jérôme Vicogne
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2020, 59 (17), pp.6720-6723. ⟨10.1002/anie.201915352⟩
Angewandte Chemie International Edition, 2020, 59 (17), pp.6720-6723. ⟨10.1002/anie.201915352⟩
Angewandte Chemie
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2020, 59 (17), pp.6720-6723. ⟨10.1002/anie.201915352⟩
Angewandte Chemie International Edition, 2020, 59 (17), pp.6720-6723. ⟨10.1002/anie.201915352⟩
Angewandte Chemie
International audience; Receptor tyrosine kinases (RTKs) are key regulators of cellular functions in metazoans. In vertebrates, RTKs are mostly activated by polypeptides but are not naturally sensitive to amino acids or light. Taking inspiration from
Autor:
Alvaro Ingles-Prieto, Douglas B. Kell, Laura H. Heitman, Daniela Digles, Stefanie Kickinger, Patrick Altermatt, Diana Zindel, Adriaan P. IJzerman, Vanessa Schneider, Daniel Körzö, Maria Wilhelm, Tabea Wiedmer, Helena Batoulis, Sara Tremolada, Giulio Superti-Furga, Anna Lena Steck, Marina Wright Muelas, Thomas Licher, Eckhard Bender, Vojtech Dvorak, Hubert J. Sijben, Avner Schlessinger, Franz Dürrenberger, Francesca Sassone, Vania Manolova, Riccardo Rizzetto, Philipp Leippe, Lia Scarabottolo, Felix Bärenz, Hanna Sundström, Claire M. Steppan
Publikováno v:
Frontiers in Pharmacology
Dvorak, V, Wiedmer, T, Ingles-Prieto, A, Altermatt, P, Batoulis, H, Bärenz, F, Bender, E, Digles, D, Dürrenberger, F, Heitman, L H, IJzerman, A P, Kell, D B, Kickinger, S, Körzö, D, Leippe, P, Licher, T, Manolova, V, Rizzetto, R, Sassone, F, Scarabottolo, L, Schlessinger, A, Schneider, V, Sijben, H J, Steck, A L, Sundström, H, Tremolada, S, Wilhelm, M, Wright Muelas, M, Zindel, D, Steppan, C M & Superti-Furga, G 2021, ' An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters ', Frontiers in Pharmacology, vol. 12, 722889 . https://doi.org/10.3389/fphar.2021.722889
Frontiers in Pharmacology, 12, 722889
Frontiers in pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Dvorak, V, Wiedmer, T, Ingles-Prieto, A, Altermatt, P, Batoulis, H, Bärenz, F, Bender, E, Digles, D, Dürrenberger, F, Heitman, L H, IJzerman, A P, Kell, D B, Kickinger, S, Körzö, D, Leippe, P, Licher, T, Manolova, V, Rizzetto, R, Sassone, F, Scarabottolo, L, Schlessinger, A, Schneider, V, Sijben, H J, Steck, A L, Sundström, H, Tremolada, S, Wilhelm, M, Wright Muelas, M, Zindel, D, Steppan, C M & Superti-Furga, G 2021, ' An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters ', Frontiers in Pharmacology, vol. 12, 722889 . https://doi.org/10.3389/fphar.2021.722889
Frontiers in Pharmacology, 12, 722889
Frontiers in pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
The solute carrier (SLC) superfamily represents the biggest family of transporters with important roles in health and disease. Despite being attractive and druggable targets, the majority of SLCs remains understudied. One major hurdle in research on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c538438b273fae113d94d4db91b031c
https://phaidra.univie.ac.at/o:1603733
https://phaidra.univie.ac.at/o:1603733
Autor:
Dirk Trauner, Michael A. Imhof, James A. Frank, Christian P. Bold, Philipp Leippe, Jessica M. Grandner, Matthias Westphal, Amey Dhopeshwarkar, Michael A. Schafroth, Roman C. Sarott, Vsevolod Katritch, Erick M. Carreira, Ken Mackie
Publikováno v:
Journal of the American Chemical Society. 139:18206-18212
The cannabinoid receptor 1 (CB1) is an inhibitory G protein-coupled receptor abundantly expressed in the central nervous system. It has rich pharmacology and largely accounts for the recreational use of cannabis. We describe efficient asymmetric synt
Publikováno v:
Biochemistry. 56:5214-5220
Genetics and pharmacology are often seen as two distinct approaches to interrogating, elucidating, and manipulating biological systems. The former is renowned for its precision whereas the latter for its fast kinetics, reversibility, and practicality