Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Philipp Kapranov"'
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Background We recently developed two high-resolution methods for genome-wide mapping of two prominent types of DNA damage, single-strand DNA breaks (SSBs) and abasic (AP) sites and found highly complex and non-random patterns of these lesion
Externí odkaz:
https://doaj.org/article/cb42d8e347ca4d26b7f8c497150a21e8
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-31 (2023)
Abstract Background Fraction of functional sequence in the human genome remains a key unresolved question in Biology and the subject of vigorous debate. While a plethora of studies have connected a significant fraction of human DNA to various biochem
Externí odkaz:
https://doaj.org/article/1682f5f597db41ec819fa044823ad045
Autor:
Fang Wang, Huifen Cao, Qiu Xia, Ziheng Liu, Ming Wang, Fan Gao, Dongyang Xu, Bolin Deng, Yong Diao, Philipp Kapranov
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Background Conversion or editing of adenosine (A) into inosine (I) catalyzed by specialized cellular enzymes represents one of the most common post-transcriptional RNA modifications with emerging connection to disease. A-to-I conversions can
Externí odkaz:
https://doaj.org/article/1ccf092095bb4229bc8f8b85cb8bf391
Autor:
Tanner Stokes, Haoning Howard Cen, Philipp Kapranov, Iain J Gallagher, Andrew A. Pitsillides, Claude‐Henry Volmar, William E Kraus, James D. Johnson, Stuart M. Phillips, Claes Wahlestedt, James A. Timmons
Publikováno v:
Advanced Genetics, Vol 4, Iss 2, Pp n/a-n/a (2023)
Abstract Sequencing the human genome empowers translational medicine, facilitating transcriptome‐wide molecular diagnosis, pathway biology, and drug repositioning. Initially, microarrays are used to study the bulk transcriptome; but now short‐rea
Externí odkaz:
https://doaj.org/article/e905fbd859144cbe92af1c8b24906620
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Abasic (AP) sites represent a prominent type of DNA damage, yet the genomics of this lesion remains unexplored. Here, the authors report a method to map such sites at the nucleotide level in complex genomes and use it to extract complex age- and tiss
Externí odkaz:
https://doaj.org/article/464db374b82548cf8d230a3ef9ea8197
Autor:
Dongyang Xu, Yu Huang, Lingcong Luo, Lu Tang, Meng Lu, Huifen Cao, Fang Wang, Yong Diao, Liudmila Lyubchenko, Philipp Kapranov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12062 (2023)
Endogenous single-stranded DNA (essDNA) can form in a mammalian genome as the result of a variety of molecular processes and can both play important roles inside the cell as well as have detrimental consequences to genome integrity, much of which rem
Externí odkaz:
https://doaj.org/article/0cd0a6c144d04d0c945631a6b8f5ff54
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9711 (2023)
The proper replication of mitochondrial DNA is key to the maintenance of this crucial organelle. Multiple studies aimed at understanding the mechanisms of replication of the mitochondrial genome have been conducted in the past several decades; howeve
Externí odkaz:
https://doaj.org/article/b647bdc8a41d4c5fb621e10a37da20ed
Autor:
Zhonghua Du, Xue Wen, Yichen Wang, Lin Jia, Shilin Zhang, Yudi Liu, Lei Zhou, Hui Li, Wang Yang, Cong Wang, Jingcheng Chen, Yajing Hao, Huiling Chen, Dan Li, Naifei Chen, Ilkay Celik, Yanbo Zhu, Zi Yan, Changhao Fu, Shanshan Liu, Benzheng Jiao, Zhuo Wang, Hui Zhang, Günhan Gülsoy, Jianjun Luo, Baoming Qin, Sujun Gao, Philipp Kapranov, Miguel A. Esteban, Songling Zhang, Wei Li, Ferhat Ay, Runsheng Chen, Andrew R. Hoffman, Jiuwei Cui, Ji-Fan Hu
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-29 (2021)
Abstract Background A specific 3-dimensional intrachromosomal architecture of core stem cell factor genes is required to reprogram a somatic cell into pluripotency. As little is known about the epigenetic readers that orchestrate this architectural r
Externí odkaz:
https://doaj.org/article/2ce0442b8dc449168fea014f3b305641
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Single-strand breaks (SSBs) represent one of the most common types of DNA damage, yet not much is known about the genome landscapes of this type of DNA lesions in mammalian cells. Here, we found that SSBs are more likely to occur in certain positions
Externí odkaz:
https://doaj.org/article/1f411da3401049929af86ef1f9ad3472
Autor:
Huifen Cao, Dongyang Xu, Ye Cai, Xueer Han, Lu Tang, Fan Gao, Yao Qi, DingDing Cai, Huifang Wang, Maxim Ri, Denis Antonets, Yuri Vyatkin, Yue Chen, Xiang You, Fang Wang, Estelle Nicolas, Philipp Kapranov
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-24 (2021)
Abstract Background The majority of the human genome is transcribed in the form of long non-coding (lnc) RNAs. While these transcripts have attracted considerable interest, their molecular mechanisms of function and biological significance remain con
Externí odkaz:
https://doaj.org/article/f8c11f8e08bb498fa81fb30c0f58843e