Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Philipp Kanis"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
Some DNA sequences are refractory to CRISPR-Cas9 cleavage, partially due to gRNA misfolding. Here the authors engineer gRNAs to prevent misfolding and further enhanced their stability by chemical modifications allowing robust genome editing regardles
Externí odkaz:
https://doaj.org/article/3c3aabf79278436ca06ea285e96b069d
Autor:
Tomislav Maricic, Olaf Nickel, Ayinuer Aximu-Petri, Elena Essel, Marie Gansauge, Philipp Kanis, Dominik Macak, Julia Richter, Stephan Riesenberg, Lukas Bokelmann, Hugo Zeberg, Matthias Meyer, Stephan Borte, Svante Pääbo
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244824 (2020)
SARS-CoV-2 causes substantial morbidity and mortality in elderly and immunocompromised individuals, particularly in retirement homes, where transmission from asymptomatic staff and visitors may introduce the infection. Here we present a cheap and fas
Externí odkaz:
https://doaj.org/article/8a1c1150aec14acf837e3851ebb86c05
Autor:
Felipe Mora-Bermúdez, Philipp Kanis, Dominik Macak, Jula Peters, Ronald Naumann, Lei Xing, Mihail Sarov, Sylke Winkler, Christina Eugster Oegema, Christiane Haffner, Pauline Wimberger, Stephan Riesenberg, Tomislav Maricic, Wieland B. Huttner, Svante Pääbo
Publikováno v:
Science Advances
Since the ancestors of modern humans separated from those of Neandertals, around one hundred amino acid substitutions spread to essentially all modern humans. The biological significance of these changes is largely unknown. Here, we examine all six s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6420aa6be24d1313f005e54a79aee3c
https://doi.org/10.1101/2022.03.30.486431
https://doi.org/10.1101/2022.03.30.486431
Autor:
Stephan Riesenberg, Tomislav Maricic, Martin Lackner, Philipp Kanis, Svante Pääbo, Dominik Macak, Agrafena Daria Pugach-Matveeva, Nelly Helmbrecht
Publikováno v:
Science. 374
Trujillo et al . (Research Articles, 12 February 2021, eaax2537) conclude that the reintroduction of an ancestral amino acid substitution in the protein NOVA1 drastically alters the development of brain organoids. We show that cell lines used by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4aab9946bfadfbf82d46c21704c1a2d9
https://doi.org/10.1126/science.abi6060
https://doi.org/10.1126/science.abi6060
Autor:
Tomislav, Maricic, Nelly, Helmbrecht, Stephan, Riesenberg, Dominik, Macak, Philipp, Kanis, Martin, Lackner, Agrafena Daria, Pugach-Matveeva, Svante, Pääbo
Publikováno v:
Science (New York, N.Y.). 374(6565)
Trujillo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d191a8ebed0753ecb682fc44666cacec
https://pubmed.ncbi.nlm.nih.gov/34648331
https://pubmed.ncbi.nlm.nih.gov/34648331
Autor:
Svante Pääbo, Julia Richter, Tomislav Maricic, Matthias Meyer, Olaf Nickel, Dominik Macak, Stephan Borte, Stephan Riesenberg, Philipp Kanis, Lukas Bokelmann, Marie Theres Gansauge, Elena Essel, Hugo Zeberg, Ayinuer Aximu-Petri
Publikováno v:
PLoS ONE
PLoS One
PLoS ONE, Vol 15, Iss 12, p e0244824 (2020)
PLoS One
PLoS ONE, Vol 15, Iss 12, p e0244824 (2020)
SARS-CoV-2 causes substantial morbidity and mortality in elderly and immunocompromised individuals, particularly in retirement homes, where transmission from asymptomatic staff and visitors may introduce the infection. Here we present a cheap and fas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008e269cdaadbbd43bb91150ddac0e55
http://europepmc.org/articles/PMC7774962
http://europepmc.org/articles/PMC7774962
Autor:
Svante Pääbo, Stephan Riesenberg, Manjusha Chintalapati, Dominik Macak, Philipp Kanis, Tomislav Maricic
Publikováno v:
Nucleic Acids Research
When double-strand breaks are introduced in a genome by CRISPR they are repaired either by non-homologous end joining (NHEJ), which often results in insertions or deletions (indels), or by homology-directed repair (HDR), which allows precise nucleoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26e7b10d7e506af1a3d02c149df1dba
https://doi.org/10.1093/nar/gkz669
https://doi.org/10.1093/nar/gkz669