Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Philipp J. Hohensinner"'
Autor:
Max Lenz, Attila Kiss, Patrick Haider, Manuel Salzmann, Mira Brekalo, Konstantin A. Krychtiuk, Ouafa Hamza, Kurt Huber, Christian Hengstenberg, Bruno K. Podesser, Johann Wojta, Philipp J. Hohensinner, Walter S. Speidl
Publikováno v:
ESC Heart Failure, Vol 10, Iss 4, Pp 2375-2385 (2023)
Abstract Aims Ischaemia–reperfusion injury (IRI) following myocardial infarction remains a challenging topic in acute cardiac care and consecutively arising heart failure represents a severe long‐term consequence. The extent of neutrophil infiltr
Externí odkaz:
https://doaj.org/article/de00d7be3709411fa79d279925966fdc
Autor:
Eva van Ingen, Amanda C. Foks, Tamar Woudenberg, M. Leontien van der Bent, Alwin de Jong, Philipp J. Hohensinner, Johann Wojta, Ilze Bot, Paul.H.A. Quax, Anne Yaël Nossent
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 1228-1239 (2021)
We have previously shown that treatment with third-generation antisense oligonucleotides against miR-494-3p (3GA-494) reduces atherosclerotic plaque progression and stabilizes lesions, both in early and established plaques, with reduced macrophage co
Externí odkaz:
https://doaj.org/article/3c732ba897314891bf7651163691b08a
Autor:
Manuel Salzmann, Patrick Haider, Christoph Kaun, Mira Brekalo, Boris Hartmann, Theresia Lengheimer, Rebecca Pichler, Thomas Filip, Sophia Derdak, Bruno Podesser, Christian Hengstenberg, Walter S. Speidl, Johann Wojta, Roberto Plasenzotti, Philipp J. Hohensinner
Publikováno v:
Journal of Innate Immunity, Pp 1-13 (2021)
Training of the innate immune system with orally ingested bacterial extracts was demonstrated to have beneficial effects on infection clearance and disease outcome. The aim of our study was to identify cellular and molecular processes responsible for
Externí odkaz:
https://doaj.org/article/29d288b1ebad47b4a34ad65a3bd7db21
Autor:
Patrick Haider, Timothy Hoberstorfer, Manuel Salzmann, Michael B. Fischer, Walter S. Speidl, Johann Wojta, Philipp J. Hohensinner
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1881 (2022)
Quantitative and functional analysis of mononuclear leukocyte populations is an invaluable tool to understand the role of the immune system in the pathogenesis of a disease. Cryopreservation of mononuclear cells (MNCs) is routinely used to guarantee
Externí odkaz:
https://doaj.org/article/b418b084f1844f0398cf482c2148c264
Autor:
Philipp J. Hohensinner, Julia Mayer, Julia Kichbacher, Julia Kral-Pointner, Barbara Thaler, Christoph Kaun, Lena Hell, Patrick Haider, Marion Mussbacher, Johannes A. Schmid, Stefan Stojkovic, Svitlana Demyanets, Michael B. Fischer, Kurt Huber, Katharina Wöran, Christian Hengstenberg, Walter S. Speidl, Rudolf Oehler, Ingrid Pabinger, Johann Wojta
Publikováno v:
Haematologica, Vol 106, Iss 2 (2020)
Macrophages are versatile cells that can be polarized by the tissue environment to fulfill required needs. Proinflammatory polarization is associated with increased tissue degradation and propagation of inflammation whereas alternative polarization w
Externí odkaz:
https://doaj.org/article/c88174e20a0542a79f36b73e83873944
Autor:
Max Lenz, Christoph Kaun, Konstantin A. Krychtiuk, Patrick Haider, Mira Brekalo, Nadine Maier, Laura Goederle, Christoph J. Binder, Kurt Huber, Christian Hengstenberg, Johann Wojta, Philipp J. Hohensinner, Walter S. Speidl
Publikováno v:
Biomedicines, Vol 9, Iss 2, p 120 (2021)
Nicorandil, a balanced vasodilator, is used in the second-line therapy of angina pectoris. In this study, we aimed to illuminate the effects of nicorandil on inflammation, apoptosis, and atherosclerotic plaque progression. Twenty-five LDL-R -/- mice
Externí odkaz:
https://doaj.org/article/00c1fe480bee427aa3c2a94493526cc2
Autor:
Gersina Rega-Kaun, Dorothea Ritzel, Christoph Kaun, Benjamin Ebenbauer, Barbara Thaler, Manfred Prager, Svitlana Demyanets, Johann Wojta, Philipp J. Hohensinner
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2153 (2019)
Circulating extracellular vesicles are small particles enclosed by a phospholipid bilayer. Vesicles deriving directly from the cellular membrane by an active budding process retain cell origin specific proteins and RNA. These vesicles carry pathophys
Externí odkaz:
https://doaj.org/article/51d252b23080426f853c17107ad2ca5b
Autor:
Patrick Haider, Julia B. Kral‐Pointner, Manuel Salzmann, Florian Moik, Sonja Bleichert, Waltraud C. Schrottmaier, Christoph Kaun, Mira Brekalo, Michael B. Fischer, Walter S. Speidl, Christian Hengstenberg, Bruno K. Podesser, Kurt Huber, Ingrid Pabinger, Sylvia Knapp, Frank Brombacher, Christine Brostjan, Cihan Ay, Johann Wojta, Philipp J. Hohensinner
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36(10)
Interleukin-4 (IL-4) and its receptors (IL-4R) promote the proliferation and polarization of macrophages. However, it is unknown if IL-4R also influences monocyte homeostasis and if steady state IL-4 levels are sufficient to affect monocytes. Employi
Autor:
Stefan P. Kastl, Philipp J. Hohensinner, Max Lenz, Johann Wojta, Stanislav Oravec, Kurt Huber, Lore Schrutka, Christian Hengstenberg, Klaus Distelmaier, Konstantin A. Krychtiuk, Elisabeth Dostal, Walter S. Speidl
Publikováno v:
Journal of Clinical Lipidology. 15:512-521
BACKGROUND Proprotein convertase subtilisin/kexin type-9 (PCSK9) is an enzyme promoting the degradation of low-density lipoprotein receptors (LDL-R) in hepatocytes. Inhibition of PCSK9 has emerged as a novel target for lipid-lowering therapy. Monocyt
Autor:
Max, Lenz, Manuel, Salzmann, Cosmin I, Ciotu, Christoph, Kaun, Konstantin A, Krychtiuk, Andreja, Rehberger Likozar, Miran, Sebestjen, Laura, Goederle, Sabine, Rauscher, Zoriza, Krivaja, Christoph J, Binder, Kurt, Huber, Christian, Hengstenberg, Bruno K, Podesser, Michael J M, Fischer, Johann, Wojta, Philipp J, Hohensinner, Walter S, Speidl
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(29)
Changes in Ca2