Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Philipp J Kahle"'
Autor:
Marc Emmenegger, Elena De Cecco, Marian Hruska‐Plochan, Timo Eninger, Matthias M Schneider, Melanie Barth, Elena Tantardini, Pierre de Rossi, Mehtap Bacioglu, Rebekah G Langston, Alice Kaganovich, Nora Bengoa‐Vergniory, Andrès Gonzalez‐Guerra, Merve Avar, Daniel Heinzer, Regina Reimann, Lisa M Häsler, Therese W Herling, Naunehal S Matharu, Natalie Landeck, Kelvin Luk, Ronald Melki, Philipp J Kahle, Simone Hornemann, Tuomas P J Knowles, Mark R Cookson, Magdalini Polymenidou, Mathias Jucker, Adriano Aguzzi
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 9, Pp n/a-n/a (2021)
Abstract While the initial pathology of Parkinson’s disease and other α‐synucleinopathies is often confined to circumscribed brain regions, it can spread and progressively affect adjacent and distant brain locales. This process may be controlled
Externí odkaz:
https://doaj.org/article/7994f076bf964ea9bf26f7f4ba6a434a
Autor:
Christine L Kragh, Gwenaëlle Fillon, Amanda Gysbers, Hanne D Hansen, Manuela Neumann, Christiane Richter-Landsberg, Christian Haass, Bernard Zalc, Catherine Lubetzki, Wei-Ping Gai, Glenda M Halliday, Philipp J Kahle, Poul H Jensen
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55243 (2013)
Multiple system atrophy is a parkinsonian neurodegenerative disorder. It is cytopathologically characterized by accumulation of the protein p25α in cell bodies of oligodendrocytes followed by accumulation of aggregated α-synuclein in so-called glia
Externí odkaz:
https://doaj.org/article/dfe9de98d91a41d4b10599e94bc1d1e2
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50245 (2012)
α-Synuclein (αSYN) is genetically and neuropathologically linked to a spectrum of neurodegenerative diseases including Parkinson's disease, dementia with Lewy bodies, and related disorders. Cognitive impairment is recapitulated in several αSYN tra
Externí odkaz:
https://doaj.org/article/860ee88a1312470bb2c81090ebce0378
Autor:
Claus Rieker, Kumlesh K Dev, Katja Lehnhoff, Samuel Barbieri, Iwona Ksiazek, Sabine Kauffmann, Simone Danner, Heinrich Schell, Cindy Boden, Markus A Ruegg, Philipp J Kahle, Herman van der Putten, Derya R Shimshek
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24834 (2011)
α-Synuclein (αSN) in human is tightly linked both neuropathologically and genetically to Parkinson's disease (PD) and related disorders. Disease-causing properties in vivo of the wildtype mouse ortholog (mαSN), which carries a threonine at positio
Externí odkaz:
https://doaj.org/article/11f98a114ce54e4184f6ed32790c76e8
Autor:
Guido Krebiehl, Sabine Ruckerbauer, Lena F Burbulla, Nicole Kieper, Brigitte Maurer, Jens Waak, Hartwig Wolburg, Zemfira Gizatullina, Frank N Gellerich, Dirk Woitalla, Olaf Riess, Philipp J Kahle, Tassula Proikas-Cezanne, Rejko Krüger
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9367 (2010)
Mitochondrial dysfunction and degradation takes a central role in current paradigms of neurodegeneration in Parkinson's disease (PD). Loss of DJ-1 function is a rare cause of familial PD. Although a critical role of DJ-1 in oxidative stress response
Externí odkaz:
https://doaj.org/article/2827ee8ffc42454eaa41fbf59e0c880b
Autor:
Aaron Voigt, David Herholz, Fabienne C Fiesel, Kavita Kaur, Daniel Müller, Peter Karsten, Stephanie S Weber, Philipp J Kahle, Till Marquardt, Jörg B Schulz
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12247 (2010)
Alteration and/or mutations of the ribonucleoprotein TDP-43 have been firmly linked to human neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The relative impacts of TDP-43 altera
Externí odkaz:
https://doaj.org/article/86e847ee41034d6f8fcb7955681c90b7
Autor:
Margot Fournier, Jérémie Vitte, Jérôme Garrigue, Dominique Langui, Jean-Philippe Dullin, Françoise Saurini, Naïma Hanoun, Fernando Perez-Diaz, Fabien Cornilleau, Chantal Joubert, Héctor Ardila-Osorio, Sabine Traver, René Duchateau, Cécile Goujet-Zalc, Katerina Paleologou, Hilal A Lashuel, Christian Haass, Charles Duyckaerts, Charles Cohen-Salmon, Philipp J Kahle, Michel Hamon, Alexis Brice, Olga Corti
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6629 (2009)
In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally. Parkin, an ubiquitin-protein ligase that is dysfunctional in autosomal
Externí odkaz:
https://doaj.org/article/3b68bd1a5b804cd19da875320f51d756
Autor:
Anna Lechado-Terradas, Sandra Schepers, Katharina I. Zittlau, Karan Sharma, Orkun Ok, Julia C. Fitzgerald, Stefan Geimer, Benedikt Westermann, Boris Macek, Philipp J. Kahle
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 576-602 (2022)
PINK1/parkin-dependent mitophagy initially involves (phospho)ubiquitin-directed proteasome-dependent degradation of certain outer mitochondrial membrane (OMM) proteins (e.g. mitofusins) and the recruitment of autophagy adaptors to a group of ubiquiti
Externí odkaz:
https://doaj.org/article/28921611ba294240a516a15b1a04f119
Autor:
Gaye Tanriöver, Mehtap Bacioglu, Manuel Schweighauser, Jasmin Mahler, Bettina M. Wegenast-Braun, Angelos Skodras, Ulrike Obermüller, Melanie Barth, Deborah Kronenberg-Versteeg, K. Peter R. Nilsson, Derya R. Shimshek, Philipp J. Kahle, Yvonne S. Eisele, Mathias Jucker
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-11 (2020)
Abstract Alpha-synucleinopathies are a group of progressive neurodegenerative disorders, characterized by intracellular deposits of aggregated α-synuclein (αS). The clinical heterogeneity of these diseases is thought to be attributed to conformers
Externí odkaz:
https://doaj.org/article/d21f1979370c47cc9fcbb8419a787497
Autor:
Alexander Kilzheimer, Thomas Hentrich, Carola Rotermund, Philipp J Kahle, Julia M Schulze-Hentrich
Publikováno v:
Human molecular genetics 32(3), 450-461 (2023). doi:10.1093/hmg/ddac205
Nutritional influences have been discussed as potential modulators of Parkinson’s disease (PD) pathology through various epidemiological and physiological studies. In animal models, a high-fat diet (HFD) with greater intake of lipid-derived calorie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1796898c93b59fc865d9cb30511ebb
https://doi.org/10.1093/hmg/ddac205
https://doi.org/10.1093/hmg/ddac205