Zobrazeno 1 - 10
of 298
pro vyhledávání: '"Philipp J Kahle"'
Autor:
Anna Lechado-Terradas, Sandra Schepers, Katharina I. Zittlau, Karan Sharma, Orkun Ok, Julia C. Fitzgerald, Stefan Geimer, Benedikt Westermann, Boris Macek, Philipp J. Kahle
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 576-602 (2022)
PINK1/parkin-dependent mitophagy initially involves (phospho)ubiquitin-directed proteasome-dependent degradation of certain outer mitochondrial membrane (OMM) proteins (e.g. mitofusins) and the recruitment of autophagy adaptors to a group of ubiquiti
Externí odkaz:
https://doaj.org/article/28921611ba294240a516a15b1a04f119
Autor:
Jorge Garcia Morato, Friederike Hans, Felix von Zweydorf, Regina Feederle, Simon J. Elsässer, Angelos A. Skodras, Christian Johannes Gloeckner, Emanuele Buratti, Manuela Neumann, Philipp J. Kahle
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
TDP-43 is a nucleic acid binding protein, whose insoluble aggregates are neuropathological hallmarks of specific subsets of patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Post-translational modifications and acetyl
Externí odkaz:
https://doaj.org/article/5d612ba76c204e148f11afe0e162e337
Autor:
Melanie Barth, Mehtap Bacioglu, Niklas Schwarz, Renata Novotny, Janine Brandes, Marc Welzer, Sonia Mazzitelli, Lisa M. Häsler, Manuel Schweighauser, Thomas V. Wuttke, Deborah Kronenberg-Versteeg, Karina Fog, Malene Ambjørn, Ania Alik, Ronald Melki, Philipp J. Kahle, Derya R. Shimshek, Henner Koch, Mathias Jucker, Gaye Tanriöver
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-17 (2021)
Abstract Background Proteopathic brain lesions are a hallmark of many age-related neurodegenerative diseases including synucleinopathies and develop at least a decade before the onset of clinical symptoms. Thus, understanding of the initiation and pr
Externí odkaz:
https://doaj.org/article/09a2047b1a9c471c8a762f64027b5264
Autor:
Gaye Tanriöver, Mehtap Bacioglu, Manuel Schweighauser, Jasmin Mahler, Bettina M. Wegenast-Braun, Angelos Skodras, Ulrike Obermüller, Melanie Barth, Deborah Kronenberg-Versteeg, K. Peter R. Nilsson, Derya R. Shimshek, Philipp J. Kahle, Yvonne S. Eisele, Mathias Jucker
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-11 (2020)
Abstract Alpha-synucleinopathies are a group of progressive neurodegenerative disorders, characterized by intracellular deposits of aggregated α-synuclein (αS). The clinical heterogeneity of these diseases is thought to be attributed to conformers
Externí odkaz:
https://doaj.org/article/d21f1979370c47cc9fcbb8419a787497
Autor:
Marc Emmenegger, Elena De Cecco, Marian Hruska‐Plochan, Timo Eninger, Matthias M Schneider, Melanie Barth, Elena Tantardini, Pierre de Rossi, Mehtap Bacioglu, Rebekah G Langston, Alice Kaganovich, Nora Bengoa‐Vergniory, Andrès Gonzalez‐Guerra, Merve Avar, Daniel Heinzer, Regina Reimann, Lisa M Häsler, Therese W Herling, Naunehal S Matharu, Natalie Landeck, Kelvin Luk, Ronald Melki, Philipp J Kahle, Simone Hornemann, Tuomas P J Knowles, Mark R Cookson, Magdalini Polymenidou, Mathias Jucker, Adriano Aguzzi
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 9, Pp n/a-n/a (2021)
Abstract While the initial pathology of Parkinson’s disease and other α‐synucleinopathies is often confined to circumscribed brain regions, it can spread and progressively affect adjacent and distant brain locales. This process may be controlled
Externí odkaz:
https://doaj.org/article/7994f076bf964ea9bf26f7f4ba6a434a
Autor:
Christine Bus, Laimdota Zizmare, Marita Feldkaemper, Sven Geisler, Maria Zarani, Anna Schaedler, Franziska Klose, Jakob Admard, Craig J. Mageean, Giuseppe Arena, Petra Fallier-Becker, Aslihan Ugun-Klusek, Klaudia K. Maruszczak, Konstantina Kapolou, Benjamin Schmid, Doron Rapaport, Marius Ueffing, Nicolas Casadei, Rejko Krüger, Thomas Gasser, Daniela M. Vogt Weisenhorn, Philipp J. Kahle, Christoph Trautwein, Christian J. Gloeckner, Julia C. Fitzgerald
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101797- (2020)
Summary: PINK1 loss-of-function mutations cause early onset Parkinson disease. PINK1-Parkin mediated mitophagy has been well studied, but the relevance of the endogenous process in the brain is debated.Here, the absence of PINK1 in human dopaminergic
Externí odkaz:
https://doaj.org/article/2face2d98c5c4f1ab1e9729b358fa6c2
Autor:
Alexander Kilzheimer, Thomas Hentrich, Carola Rotermund, Philipp J Kahle, Julia M Schulze-Hentrich
Publikováno v:
Human molecular genetics 32(3), 450-461 (2023). doi:10.1093/hmg/ddac205
Nutritional influences have been discussed as potential modulators of Parkinson’s disease (PD) pathology through various epidemiological and physiological studies. In animal models, a high-fat diet (HFD) with greater intake of lipid-derived calorie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1796898c93b59fc865d9cb30511ebb
https://doi.org/10.1093/hmg/ddac205
https://doi.org/10.1093/hmg/ddac205
Autor:
Mareike Fauser, Francisco Pan-Montojo, Christian Richter, Philipp J. Kahle, Sigrid C. Schwarz, Johannes Schwarz, Alexander Storch, Andreas Hermann
Publikováno v:
Cells, Vol 10, Iss 4, p 775 (2021)
Background: Consecutive adult neurogenesis is a well-known phenomenon in the ventricular–subventricular zone of the lateral wall of the lateral ventricles (V–SVZ) and has been controversially discussed in so-called “non-neurogenic” brain area
Externí odkaz:
https://doaj.org/article/f772cd490c0641ef939e1bdaac1ca13e
Autor:
Zinah Wassouf, Thomas Hentrich, Sebastian Samer, Carola Rotermund, Philipp J. Kahle, Ingrid Ehrlich, Olaf Riess, Nicolas Casadei, Julia M. Schulze-Hentrich
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Onset and progression of neurodegenerative disorders, including synucleinopathies such as Parkinson's disease, have been associated with various environmental factors. A highly compelling association from a therapeutic point of view has been found be
Externí odkaz:
https://doaj.org/article/90ceed3b20be48ecac836caa5beb3cd3
Autor:
Philipp J. Kahle, Renee C Gentzel, Lei Ma, Jacob Marcus, Sean M. Smith, Dawn Toolan, Joel B. Schachter, Sarah Jinn
Publikováno v:
Neurobiology of aging 106, 12-25 (2021). doi:10.1016/j.neurobiolaging.2021.05.012
Synucleinopathies are neurodegenerative disorders involving pathological alpha-synuclein (αSyn) protein, including dementia with Lewy bodies, multiple system atrophy and Parkinson's disease (PD). Current in vivo models of synucleinopathy include tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd63ea6b0e4145e8f82abc6da25eeae2
https://doi.org/10.1016/j.neurobiolaging.2021.05.012
https://doi.org/10.1016/j.neurobiolaging.2021.05.012