Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Philipp Hohlstein"'
Autor:
Philipp Hohlstein, Can Salvarcioglu, Maike R. Pollmanns, Jule K. Adams, Samira Abu Jhaisha, Elena Kabak, Albrecht Eisert, Karim Hamesch, Ralf Weiskirchen, Alexander Koch, Theresa H. Wirtz
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1170 (2024)
Differentiation between acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) can be challenging in patients with de novo liver disease but is important to indicate the referral to a transplant center and urgency of organ allocation. Le
Externí odkaz:
https://doaj.org/article/d0e07589ebb64b8a8ef6834367d396bb
Autor:
Jonathan Frederik Brozat, Neval Harbalioğlu, Philipp Hohlstein, Samira Abu Jhaisha, Maike Rebecca Pollmanns, Jule Katharina Adams, Theresa Hildegard Wirtz, Karim Hamesch, Eray Yagmur, Ralf Weiskirchen, Frank Tacke, Christian Trautwein, Alexander Koch
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5819 (2024)
The kidney injury molecule (KIM)-1 is shed from proximal tubular cells in acute kidney injury (AKI), relaying tubular epithelial proliferation. Additionally, KIM-1 portends complex immunoregulation and is elevated after exposure to lipopolysaccharide
Externí odkaz:
https://doaj.org/article/b649995df0ba499dbbb3ae83023b9424
Autor:
Philipp Hohlstein, Eileen Schumacher, Samira Abu Jhaisha, Jule K. Adams, Maike R. Pollmanns, Carolin V. Schneider, Karim Hamesch, Katarina Horvathova, Theresa H. Wirtz, Frank Tacke, Christian Trautwein, Ralf Weiskirchen, Alexander Koch
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5438 (2024)
Critical illness and sepsis may cause organ failure and are recognized as mortality drivers in hospitalized patients. Neuropilin-1 (NRP-1) is a multifaceted transmembrane protein involved in the primary immune response and is expressed in immune cell
Externí odkaz:
https://doaj.org/article/6b32e986c19b46f08d8ab7f1b555de0f
Autor:
Samira Abu Jhaisha, Philipp Hohlstein, Eray Yagmur, Vera Köller, Maike R. Pollmanns, Jule K. Adams, Theresa H. Wirtz, Jonathan F. Brozat, Lukas Bündgens, Karim Hamesch, Ralf Weiskirchen, Frank Tacke, Christian Trautwein, Alexander Koch
Publikováno v:
Diagnostics, Vol 14, Iss 4, p 370 (2024)
Semaphorin 4D (Sema4D), also known as CD100, is a multifunctional transmembrane protein with immunoregulatory functions. Upon the activation of immune cells, soluble Semaphorin 4D (sSema4D) is proteolytically cleaved from the membrane by metalloprote
Externí odkaz:
https://doaj.org/article/554721f4a4dc4cd281bbfb12761d0fc6
Autor:
Philipp Hohlstein, Samira Abu Jhaisha, Eray Yagmur, Dennis Wawer, Maike R. Pollmanns, Jule K. Adams, Theresa H. Wirtz, Jonathan F. Brozat, Lukas Bündgens, Karim Hamesch, Ralf Weiskirchen, Frank Tacke, Christian Trautwein, Alexander Koch
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 454 (2023)
Midkine (Mdk) is a multifunctional protein involved in inflammatory processes. Hence, circulating Mdk is increased in sepsis and has been previously suggested as a potential biomarker in these patients. The aim of this study was to elucidate the role
Externí odkaz:
https://doaj.org/article/862d3e6c76fb43ae811e435abffacf0d
Autor:
Philipp Hohlstein, Jonathan F. Brozat, Julia Schuler, Samira Abu Jhaisha, Maike R. Pollmanns, Lukas Bündgens, Theresa H. Wirtz, Eray Yagmur, Karim Hamesch, Ralf Weiskirchen, Frank Tacke, Christian Trautwein, Alexander Koch
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 313 (2023)
Sepsis is a major health burden with insufficiently understood mechanisms of inflammation and immune paralysis, leading to a life-threatening critical illness. The secreted frizzled related protein 5 (SFRP5) acts as an anti-inflammatory adipokine by
Externí odkaz:
https://doaj.org/article/756f0be269ba487f97a8d66ec473c217
Autor:
Eray Yagmur, Samira Abu Jhaisha, Lukas Buendgens, Nadezhda Sapundzhieva, Jonathan F. Brozat, Philipp Hohlstein, Maike R. Pollmanns, Ger H. Koek, Ralf Weiskirchen, Christian Trautwein, Frank Tacke, Theresa H. Wirtz, Alexander Koch
Publikováno v:
Diagnostics, Vol 12, Iss 12, p 3010 (2022)
Clusterin is a multifunctional protein that is recognized to mediate cellular stress response associated with organ failure, systemic inflammation, and metabolic alterations. The aim of this study was to determine the value of clusterin as a clinical
Externí odkaz:
https://doaj.org/article/de9f32ba8e784f828c0135f697f59e33
Autor:
Hendrik Gussen, Philipp Hohlstein, Matthias Bartneck, Klaudia Theresa Warzecha, Lukas Buendgens, Tom Luedde, Christian Trautwein, Alexander Koch, Frank Tacke
Publikováno v:
Journal of Intensive Care, Vol 7, Iss 1, Pp 1-11 (2019)
Abstract Background Circulating levels of soluble urokinase plasminogen activation receptor (suPAR) have been proposed as a prognostic biomarker in patients with critical illness and sepsis. However, the origin of suPAR in sepsis has remained obscure
Externí odkaz:
https://doaj.org/article/a5941bf8ddb54d80a0d148c3356840f8
Autor:
Tobias Puengel, Beate Weber, Theresa H. Wirtz, Lukas Buendgens, Sven H. Loosen, Lukas Geisler, Burcin Özdirik, Karim Hamesch, Samira Abu Jhaisha, Jonathan F. Brozat, Philipp Hohlstein, Albrecht Eisert, Eray Yagmur, Christian Trautwein, Frank Tacke, Alexander Koch
Publikováno v:
Diagnostics, Vol 12, Iss 1, p 62 (2021)
Soluble receptor activator of nuclear factor κ B ligand (sRANKL) is a member of the tumor necrosis factor receptor superfamily, and therefore, involved in various inflammatory processes. The role of sRANKL in the course of bone remodeling via activa
Externí odkaz:
https://doaj.org/article/540bb2eab9084ad59a084d1375bdcb40
Autor:
Berkan Kurt, Lukas Buendgens, Theresa H. Wirtz, Sven H. Loosen, Maximilian Schulze-Hagen, Daniel Truhn, Jonathan F. Brozat, Samira Abu Jhaisha, Philipp Hohlstein, Ger Koek, Ralf Weiskirchen, Christian Trautwein, Frank Tacke, Karim Hamesch, Alexander Koch
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1210 (2021)
Perilipin 2 (PLIN2) is a lipid droplet protein with various metabolic functions. However, studies investigating PLIN2 in the context of inflammation, especially in systemic and acute inflammation, are lacking. Hence, we assessed the relevance of seru
Externí odkaz:
https://doaj.org/article/091fdb44a6ae4d3c9d726cf89cc64011