Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Philipp F. Lange"'
Autor:
Amanda C. Lorentzian, Jenna Rever, Enes K. Ergin, Meiyun Guo, Neha M. Akella, Nina Rolf, C. James Lim, Gregor S. D. Reid, Christopher A. Maxwell, Philipp F. Lange
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Childhood acute lymphoblastic leukemia (ALL) genomes show that relapses often arise from subclonal outgrowths. However, the impact of clonal evolution on the actionable proteome and response to targeted therapy is not known. Here, we present
Externí odkaz:
https://doaj.org/article/ef6d2efa7bfe46babb83d0060edfc692
Autor:
Lorenz Nierves, Jian Guo, Siyuan Chen, Janice Tsui, Anuli C. Uzozie, Jonathan W. Bush, Tao Huan, Philipp F. Lange
Publikováno v:
Experimental Hematology & Oncology, Vol 11, Iss 1, Pp 1-17 (2022)
Abstract Background The bone marrow is the place of hematopoiesis with a microenvironment that supports lifelong maintenance of stem cells and high proliferation. It is not surprising that this environment is also favourable for malignant cells emerg
Externí odkaz:
https://doaj.org/article/c2be1cea71294a85b7dd671fa50ad8b0
Autor:
Zhengcheng He, Ryan Ghorayeb, Susanna Tan, Ke Chen, Amanda C. Lorentzian, Jack Bottyan, Syed Mohammed Musheer Aalam, Miguel Angel Pujana, Philipp F. Lange, Nagarajan Kannan, Connie J. Eaves, Christopher A. Maxwell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Female carriers of BRCA1 mutations possess high breast cancer risk, which may reflect deficient growth control of mammary progenitor cells. Here, the authors study progenitor-enriched fractions from these carriers and describe a loss of PLK1-mediated
Externí odkaz:
https://doaj.org/article/dc008dd191494a1c87bda1b62ace4d8c
Autor:
Francesca Mateo, Zhengcheng He, Lin Mei, Gorka Ruiz de Garibay, Carmen Herranz, Nadia García, Amanda Lorentzian, Alexandra Baiges, Eline Blommaert, Antonio Gómez, Oriol Mirallas, Anna Garrido-Utrilla, Luis Palomero, Roderic Espín, Ana I. Extremera, M. Teresa Soler-Monsó, Anna Petit, Rong Li, Joan Brunet, Ke Chen, Susanna Tan, Connie J. Eaves, Curtis McCloskey, Razq Hakem, Rama Khokha, Philipp F. Lange, Conxi Lázaro, Christopher A. Maxwell, Miquel Angel Pujana
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The effect of hyaluronan-mediated motility receptor (HMMR) expression in BRCA1-associated breast cancer risk remains unknown. Here, HMMR overexpression induces the activation of cGAS-STING and non-canonical NF-κB signalling, instigating an immune pe
Externí odkaz:
https://doaj.org/article/63fe713cc69c441fb5f6ed1eab75272b
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The local sequence context is the most fundamental feature determining the post-translational modification (PTM) of proteins. Recent technological improvements allow for the detection of new and less prevalent modifications. We found that es
Externí odkaz:
https://doaj.org/article/a88892814a84403ba85f784b07c59ce3
Autor:
Anuli C. Uzozie, Enes K. Ergin, Nina Rolf, Janice Tsui, Amanda Lorentzian, Samuel S. H. Weng, Lorenz Nierves, Theodore G. Smith, C. James Lim, Christopher A. Maxwell, Gregor S. D. Reid, Philipp F. Lange
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-24 (2021)
Abstract Background Murine xenografts of pediatric leukemia accurately recapitulate genomic aberrations. How this translates to the functional capacity of cells remains unclear. Here, we studied global protein abundance, phosphorylation, and protein
Externí odkaz:
https://doaj.org/article/d322bf218f4945d68e9218ca550e6200
Autor:
Phillip A. Richmond, Frans van der Kloet, Frederic M. Vaz, David Lin, Anuli Uzozie, Emma Graham, Michael Kobor, Sara Mostafavi, Perry D. Moerland, Philipp F. Lange, Antoine H. C. van Kampen, Wyeth W. Wasserman, Marc Engelen, Stephan Kemp, Clara D. M. van Karnebeek
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
X-linked adrenoleukodystrophy (ALD) is a peroxisomal metabolic disorder with a highly complex clinical presentation. ALD is caused by mutations in the ABCD1 gene, and is characterized by the accumulation of very long-chain fatty acids in plasma and t
Externí odkaz:
https://doaj.org/article/de5049be524544098180e67278007e7b
Autor:
Anna Prudova, Vasilena Gocheva, Ulrich auf dem Keller, Ulrich Eckhard, Oakley C. Olson, Leila Akkari, Georgina S. Butler, Nikolaus Fortelny, Philipp F. Lange, Jennifer C. Mark, Johanna A. Joyce, Christopher M. Overall
Publikováno v:
Cell Reports, Vol 16, Iss 6, Pp 1762-1773 (2016)
Deregulated cathepsin proteolysis occurs across numerous cancers, but in vivo substrates mediating tumorigenesis remain ill-defined. Applying 8-plex iTRAQ terminal amine isotopic labeling of substrates (TAILS), a systems-level N-terminome degradomics
Externí odkaz:
https://doaj.org/article/175b1854b1184aa8a8318d1d641e7b94
Autor:
Ulrich Eckhard, Pitter F. Huesgen, Oliver Schilling, Caroline L. Bellac, Georgina S. Butler, Jennifer H. Cox, Antoine Dufour, Verena Goebeler, Reinhild Kappelhoff, Ulrich auf dem Keller, Theo Klein, Philipp F. Lange, Giada Marino, Charlotte J. Morrison, Anna Prudova, David Rodriguez, Amanda E. Starr, Yili Wang, Christopher M. Overall
Publikováno v:
Data in Brief, Vol 7, Iss , Pp 299-310 (2016)
The data described provide a comprehensive resource for the family-wide active site specificity portrayal of the human matrix metalloproteinase family. We used the high-throughput proteomic technique PICS (Proteomic Identification of protease Cleavag
Externí odkaz:
https://doaj.org/article/ea1cfb7a0a4643beb4babc346c545730
Autor:
Caroline L. Bellac, Antoine Dufour, Michael J. Krisinger, Anantasak Loonchanta, Amanda E. Starr, Ulrich auf dem Keller, Philipp F. Lange, Verena Goebeler, Reinhild Kappelhoff, Georgina S. Butler, Leslie D. Burtnick, Edward M. Conway, Clive R. Roberts, Christopher M. Overall
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 618-632 (2014)
Resolution of inflammation reduces pathological tissue destruction and restores tissue homeostasis. Here, we used a proteomic protease substrate discovery approach, terminal amine isotopic labeling of substrates (TAILS), to analyze the role of the ma
Externí odkaz:
https://doaj.org/article/54232a9bc7164ad28c7741c5076d0c8e