Zobrazeno 1 - 10
of 257
pro vyhledávání: '"Philipp Erben"'
Autor:
Daniel Uysal, Blerta Thaqi, Alexander Fierek, David Jurgowski, Zoran V. Popovic, Fabian Siegel, Maurice Stephan Michel, Philipp Nuhn, Thomas Stefan Worst, Philipp Erben, Katja Nitschke
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionMuscle invasive bladder cancer (MIBC) remains a prevalent cancer with limited therapeutic options, obviating the need for innovative therapies. The epidermal growth factor receptor (EGFR) is a linchpin in tumor progression and presents a
Externí odkaz:
https://doaj.org/article/f99abe57e02c45058530681e62a58470
Autor:
Johannes Breyer, Markus Eckstein, Danijel Sikic, Felix Wezel, Florian Roghmann, Mirco Brehmer, Ralph M. Wirtz, Jonas Jarczyk, Philipp Erben, Veronika Bahlinger, Franziska Goldschmidt, Guido Fechner, Jack Chen, Ellen Paxinos, Michael Bates, Maximilian Haas, Friedemann Zengerling, Christian Bolenz, Maximilian Burger, Arndt Hartmann, Maximilian C. Kriegmair, BRIDGE Consortium e.V.
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract To determine whether Xpert bladder cancer monitor, a noninvasive PCR-based biomarker test, can predict the need for 2nd transurethral resection of the bladder (TURB) better than clinical assessment. Patients scheduled for TURB were prospecti
Externí odkaz:
https://doaj.org/article/fa9759114ae54cec84a9f6e9dcdf03ce
Autor:
Niklas Klümper, Lennert Wüst, Jonas Saal, Damian J. Ralser, Romina Zarbl, Jonas Jarczyk, Johannes Breyer, Danijel Sikic, Bernd Wullich, Christian Bolenz, Florian Roghmann, Michael Hölzel, Manuel Ritter, Sebastian Strieth, Arndt Hartmann, Philipp Erben, Ralph M. Wirtz, Jennifer Landsberg, Dimo Dietrich, Markus Eckstein
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTPD-L1 status assessed by immunohistochemistry (IHC) has failed to reliably predict outcomes for patients with metastatic urothelial carcinoma (mUC) on immune checkpoint blockade (ICB). PD-L1 promoter methylation is an epigenetic mechanism tha
Externí odkaz:
https://doaj.org/article/db84a83835784401bcaeca4a8df3487d
Autor:
Enrico Mingardo, Glenda Beaman, Philip Grote, Agneta Nordenskjöld, William Newman, Adrian S. Woolf, Markus Eckstein, Alina C. Hilger, Gabriel C. Dworschak, Wolfgang Rösch, Anne-Karolin Ebert, Raimund Stein, Alfredo Brusco, Massimo Di Grazia, Ali Tamer, Federico M. Torres, Jose L. Hernandez, Philipp Erben, Carlo Maj, Jose M. Olmos, Jose A. Riancho, Carmen Valero, Isabel C. Hostettler, Henry Houlden, David J. Werring, Johannes Schumacher, Jan Gehlen, Ann-Sophie Giel, Benedikt C. Buerfent, Samara Arkani, Elisabeth Åkesson, Emilia Rotstein, Michael Ludwig, Gundela Holmdahl, Elisa Giorgio, Alfredo Berettini, David Keene, Raimondo M. Cervellione, Nina Younsi, Melissa Ortlieb, Josef Oswald, Bernhard Haid, Martin Promm, Claudia Neissner, Karin Hirsch, Maximilian Stehr, Frank-Mattias Schäfer, Eberhard Schmiedeke, Thomas M. Boemers, Iris A. L. M. van Rooij, Wouter F. J. Feitz, Carlo L. M. Marcelis, Martin Lacher, Jana Nelson, Benno Ure, Caroline Fortmann, Daniel P. Gale, Melanie M. Y. Chan, Kerstin U. Ludwig, Markus M. Nöthen, Stefanie Heilmann, Nadine Zwink, Ekkehart Jenetzky, Benjamin Odermatt, Michael Knapp, Heiko Reutter
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
A genome-wide association study on classic bladder exstrophy reveals eight genome-wide significant loci, most of which contained genes expressed in embryonic developmental bladder stages.
Externí odkaz:
https://doaj.org/article/3185cad232344b7081367260f4859843
Autor:
Jonas Koch, Manuel Neuberger, Martina Schmidt-Dengler, Jinyun Xu, Vitor Coutinho Carneiro, Jörg Ellinger, Maximilian C. Kriegmair, Philipp Nuhn, Philipp Erben, Maurice Stephan Michel, Mark Helm, Manuel Rodríguez-Paredes, Malin Nientiedt, Frank Lyko
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107300- (2023)
Summary: METTL3 is the major writer of N6-Methyladenosine (m6A) and has been associated with controversial roles in cancer. This is best illustrated in urothelial carcinoma of the bladder (UCB), where METTL3 was described to have both oncogenic and t
Externí odkaz:
https://doaj.org/article/9811c78962a84ac8864006c4041344a1
Autor:
Stefan Porubsky, Malin Nientiedt, Maximilian C. Kriegmair, Jörn-Helge Heinrich Siemoneit, Roger Sandhoff, Richard Jennemann, Hendrik Borgmann, Timo Gaiser, Cleo-Aron Weis, Philipp Erben, Thomas Hielscher, Zoran V. Popovic
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Renal cell carcinoma (RCC) is the deadliest primary genitourinary malignancy typically associated with asymptomatic initial presentation and poorly predictable survival. Next to established risk factors, tumor microenvironment may alter meta
Externí odkaz:
https://doaj.org/article/08f451bc6274482e842f3d75e75a5ff8
Autor:
Sheng Wu, Katja Nitschke, Thomas Stefan Worst, Alexander Fierek, Cleo-Aron Weis, Markus Eckstein, Stefan Porubsky, Maximilian Kriegmair, Philipp Erben
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-16 (2020)
Abstract Background Growing evidence supports the pivotal role of long non-coding RNAs (lncRNAs) in the regulation of cancer development and progression. Their expression patterns and biological function in muscle invasive bladder cancer (MIBC) remai
Externí odkaz:
https://doaj.org/article/4588d72d81bb4f42b76a4ba2beb76f94
Autor:
Sebastien Rinaldetti, Thomas Stefan Worst, Eugen Rempel, Maximilian C. Kriegmair, Arndt Hartmann, Stefan Porubsky, Christian Bolenz, Philipp Erben
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract Comprehensive transcriptome expression analyses of bladder cancer revealed distinct lncRNA clusters with differential molecular and clinical characteristics. In this study, pivotal lncRNAs were assessed for their impact on survival and their
Externí odkaz:
https://doaj.org/article/b06cda227a38426c96831ad2a46e9343
Autor:
Frank Waldbillig, Felix Bormann, Manuel Neuberger, Jörg Ellinger, Philipp Erben, Maximilian C. Kriegmair, Maurice Stephan Michel, Philipp Nuhn, Malin Nientiedt
Publikováno v:
Diagnostics, Vol 13, Iss 5, p 823 (2023)
To date, only a single transcriptome-wide m6A sequencing study of clear cell renal cell carcinoma (ccRCC) has been reported, with no validation so far. Herein, by TCGA analysis of the KIRC cohort (n = 530 ccRCC; n = 72 normal), an external expression
Externí odkaz:
https://doaj.org/article/5cd0ce1f84cc4962b8a595ffe2773d0d
Autor:
Danijel Sikic, Ralph M. Wirtz, Sven Wach, Lars Dyrskjøt, Philipp Erben, Christian Bolenz, Johannes Breyer, Wolfgang Otto, Katherine A. Hoadley, Seth P. Lerner, Markus Eckstein, Arndt Hartmann, Bastian Keck
Publikováno v:
Translational Oncology, Vol 12, Iss 4, Pp 661-668 (2019)
INTRODUCTION: Gender-specific differences have led to the androgen receptor (AR) being considered a possible factor in the pathophysiology of urothelial carcinoma of the bladder (UCB), but the exact role remains unclear. MATERIALS AND METHODS: The as
Externí odkaz:
https://doaj.org/article/07ed23158aca44659eca38a9a94652e4