Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Philipp E. Geyer"'
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 3825-3834.e4 (2019)
Summary: The mosaic distribution of cytochrome c oxidase+ (COX+) and COX− muscle fibers in mitochondrial disorders allows the sampling of fibers with compensated and decompensated mitochondrial function from the same individual. We apply laser capt
Externí odkaz:
https://doaj.org/article/064c40ef553d4d9698d617080dcbec4f
Autor:
Sophia Doll, Maximilian C. Kriegmair, Alberto Santos, Michael Wierer, Fabian Coscia, Helen Michele Neil, Stefan Porubsky, Philipp E. Geyer, Andreas Mund, Philipp Nuhn, Matthias Mann
Publikováno v:
Molecular Oncology, Vol 12, Iss 8, Pp 1296-1307 (2018)
Recent advances in mass spectrometry (MS)‐based technologies are now set to transform translational cancer proteomics from an idea to a practice. Here, we present a robust proteomic workflow for the analysis of clinically relevant human cancer tiss
Externí odkaz:
https://doaj.org/article/6e9918e8416d41e08b62caaacc33540a
Autor:
Sophia Doll, Martina Dreßen, Philipp E. Geyer, Daniel N. Itzhak, Christian Braun, Stefanie A. Doppler, Florian Meier, Marcus-Andre Deutsch, Harald Lahm, Rüdiger Lange, Markus Krane, Matthias Mann
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The human heart is composed of distinct regions and cell types, but relatively little is known about their specific protein composition. Here, the authors present a region- and cell type-specific proteomic map of the healthy human heart, revealing fu
Externí odkaz:
https://doaj.org/article/567eef510a6f43498199606e690bcfcb
Autor:
Torben Hansen, Pere Ginès, Wim Laleman, Peer Bork, Vishal C Patel, Debbie Shawcross, Robert Schierwagen, Camila Alvarez-Silva, Florence Servant, Jonel Trebicka, Benjamin Lelouvier, Manimozhiyan Arumugam, Ed J Kuijper, Frank Erhard Uschner, Michael Praktiknjo, Mária Papp, Saeed Shoaie, Michael Kühn, Maja Thiele, Paolo Angeli, Joan Claria, Vicente Arroyo, Manolo Laiola, Benoit Quinquis, Sabine Klein, Minneke J Coenraad, François Fenaille, Debbie Lindsay Shawcross, Wenyi Gu, Adria Juanola, Elisa Pose, Aleksander Krag, Ivica Letunic, Alain Pruvost, Hervé M Blottière, Nathalie Galleron, Cristina López-Vicario, Peter V Treit, Matthias Mann, Jelle Matthijnssens, Mark J W Mcphail, Philipp E Geyer, Hans Olav Melberg, Stefanie Kandels, Cristina Sánchez-Garrido, Florence A Castelli, Christophe Junot, Lars Asphaug, Mads Israelsen, Helene Bæk Juel, Nikolaj Torp, Minneke Coenraad, Marko Korenjak, Ferran Aguilar-Parera, Patricia Sierra-Casas, Anna Bosch-Comas, David Tornai, Boglarka Balogh, Katrine Holtz Thorhauge, Casper Sahl Poulsen, Thea Van Rossum, Suguru Nishijima, Marisa I Keller, Diënty H M Hazenbrink, Sylvain Dechaumet, Sebastian D Burz, Emeline Chu-Van, Etienne Thévenot, Florian A Rosenberger, Sebastian Van Blerk, Amirouche Ouzerdine, Alain Roulet, Jean-Louis-Marie Insonere, Céline Serres, Mathieu Almeida, Florence Thirion, Camille Champion, Chaima Ezzine, Célia Chamignon, Nicolas Lapaque, Mamadou Gabou Thiam, Lore Van Espen, Quinten R Ducarmon, Annelotte GC Broekhoven, Susan Fischer, Romy Zwittink, Itziar De Lecuona, Giulio Rosati, Celia Fuentes-Chust, Arben Merkoçi, Massimo Urban, José Alfonso Marrugo-Ramirez, Ameli Schwalber, Lindsey Ann Edwards, Victoria Tatiana Kronsten, David Moyes, Azadeh Harzandi, Jordi Gratacós-Ginès, Martina Pérez-Guasch, Miriam Pellón, Bryan Contreras, Max Brol, Manfred Fobker, Renata Antonina Feuerborn
Publikováno v:
BMJ Open, Vol 14, Iss 2 (2024)
Introduction Human albumin is used in the treatment of complications of cirrhosis. However, the use of long-term human albumin administration is costly and resource demanding for both patients and healthcare systems. A precision medicine approach wit
Externí odkaz:
https://doaj.org/article/289f12a27d2047adb5cb758cb2809703
Autor:
Sander Wuyts, Renato Alves, Maria Zimmermann‐Kogadeeva, Suguru Nishijima, Sonja Blasche, Marja Driessen, Philipp E Geyer, Rajna Hercog, Ece Kartal, Lisa Maier, Johannes B Müller, Sarela Garcia Santamarina, Thomas Sebastian B Schmidt, Daniel C Sevin, Anja Telzerow, Peter V Treit, Tobias Wenzel, Athanasios Typas, Kiran R Patil, Matthias Mann, Michael Kuhn, Peer Bork
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 9, Pp n/a-n/a (2023)
Abstract Multi‐omics analyses are used in microbiome studies to understand molecular changes in microbial communities exposed to different conditions. However, it is not always clear how much each omics data type contributes to our understanding an
Externí odkaz:
https://doaj.org/article/fd802a62805b4d79ab0ef30a579c5470
Autor:
Lili Niu, Philipp E Geyer, Rajat Gupta, Alberto Santos, Florian Meier, Sophia Doll, Nicolai J Wewer Albrechtsen, Sabine Klein, Cristina Ortiz, Frank E Uschner, Robert Schierwagen, Jonel Trebicka, Matthias Mann
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 5, Pp n/a-n/a (2022)
Abstract Deeper understanding of liver pathophysiology would benefit from a comprehensive quantitative proteome resource at cell type resolution to predict outcome and design therapy. Here, we quantify more than 150,000 sequence‐unique peptides agg
Externí odkaz:
https://doaj.org/article/14586c35d0b34d79a042d1db8d687114
Autor:
Dari Shalon, Rebecca Neal Culver, Jessica A. Grembi, Jacob Folz, Peter V. Treit, Handuo Shi, Florian A. Rosenberger, Les Dethlefsen, Xiandong Meng, Eitan Yaffe, Andrés Aranda-Díaz, Philipp E. Geyer, Johannes B. Mueller-Reif, Sean Spencer, Andrew D. Patterson, George Triadafilopoulos, Susan P. Holmes, Matthias Mann, Oliver Fiehn, David A. Relman, Kerwyn Casey Huang
Publikováno v:
Nature, vol 617, iss 7961
The spatiotemporal structure of the human microbiome1,2, proteome3 and metabolome4,5 reflects and determines regional intestinal physiology and may have implications for disease6. Yet, little is known about the distribution of microorganisms, their e
Autor:
Manuela Thienel, Johannes B. Müller-Reif, Zhe Zhang, Vincent Ehreiser, Judith Huth, Khrystyna Shchurovska, Badr Kilani, Lisa Schweizer, Philipp E. Geyer, Maximilian Zwiebel, Julia Novotny, Enzo Lüsebrink, Gemma Little, Martin Orban, Leo Nicolai, Shaza El Nemr, Anna Titova, Michael Spannagl, Jonas Kindberg, Alina L. Evans, Orpheus Mach, Matthias Vogel, Steffen Tiedt, Steffen Ormanns, Barbara Kessler, Anne Dueck, Andrea Friebe, Peter Godsk Jørgensen, Monir Majzoub-Altweck, Andreas Blutke, Amin Polzin, Konstantin Stark, Stefan Kääb, Doris Maier, Jonathan M. Gibbins, Ulrich Limper, Ole Frobert, Matthias Mann, Steffen Massberg, Tobias Petzold
Publikováno v:
Science. 380:178-187
Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary embolism is a major cause of morbidity and mortality. Short-term immobility-related conditions are a major risk factor for the development of VTE. Paradoxically, long-term i
Autor:
Lili Niu, Maja Thiele, Philipp E. Geyer, Ditlev Nytoft Rasmussen, Henry Emanuel Webel, Alberto Santos, Rajat Gupta, Florian Meier, Maximilian Strauss, Maria Kjaergaard, Katrine Lindvig, Suganya Jacobsen, Simon Rasmussen, Torben Hansen, Aleksander Krag, Matthias Mann
Publikováno v:
Niu, L, Thiele, M, Geyer, P E, Rasmussen, D N, Webel, H E, Santos, A, Gupta, R, Meier, F, Strauss, M, Kjaergaard, M, Lindvig, K, Jacobsen, S, Rasmussen, S, Hansen, T, Krag, A & Mann, M 2022, ' Noninvasive proteomic biomarkers for alcohol-related liver disease ', Nature Medicine, vol. 28, no. 6, pp. 1277-1287 . https://doi.org/10.1038/s41591-022-01850-y
Alcohol-related liver disease (ALD) is a major cause of liver-related death worldwide, yet understanding of the three key pathological features of the disease—fibrosis, inflammation and steatosis—remains incomplete. Here, we present a paired live
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 9, Pp n/a-n/a (2017)
Abstract Clinical analysis of blood is the most widespread diagnostic procedure in medicine, and blood biomarkers are used to categorize patients and to support treatment decisions. However, existing biomarkers are far from comprehensive and often la
Externí odkaz:
https://doaj.org/article/8597294091a24bb094d91807474b5431