Zobrazeno 1 - 10
of 625
pro vyhledávání: '"Philipp E, Scherer"'
Autor:
Paul C. Lee, In-Hyuk Jung, Shreeya Thussu, Ved Patel, Ryan Wagoner, Kendall H. Burks, Junedh Amrute, Jared S. Elenbaas, Chul Joo Kang, Erica P. Young, Philipp E. Scherer, Nathan O. Stitziel
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110104- (2024)
Summary: Coronary artery disease (CAD) remains a leading cause of disease burden globally, and there is a persistent need for new therapeutic targets. Instrumental variable (IV) and genetic colocalization analyses can help identify novel therapeutic
Externí odkaz:
https://doaj.org/article/f1c5ae12bdf0423691d81d9943e37603
Autor:
Toshiharu Onodera, May-Yun Wang, Joseph M. Rutkowski, Stanislaw Deja, Shiuhwei Chen, Michael S. Balzer, Dae-Seok Kim, Xuenan Sun, Yu A. An, Bianca C. Field, Charlotte Lee, Ei-ichi Matsuo, Monika Mizerska, Ina Sanjana, Naoto Fujiwara, Christine M. Kusminski, Ruth Gordillo, Laurent Gautron, Denise K. Marciano, Ming Chang Hu, Shawn C. Burgess, Katalin Susztak, Orson W. Moe, Philipp E. Scherer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Adiponectin is a secretory protein, primarily produced in adipocytes. However, low but detectable expression of adiponectin can be observed in cell types beyond adipocytes, particularly in kidney tubular cells, but its local renal role is un
Externí odkaz:
https://doaj.org/article/6885cd75dd3641e481d840972315e815
Autor:
Toshiharu Onodera, Dae-Seok Kim, Risheng Ye, May-Yun Wang, Shiuhwei Chen, Bianca C. Field, Leon Straub, Xue-Nan Sun, Chao Li, Charlotte Lee, Megan Paredes, Clair Crewe, Shangang Zhao, Christine M. Kusminski, Ruth Gordillo, Philipp E. Scherer
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101821- (2023)
The disease progression of the metabolic syndrome is associated with prolonged hyperlipidemia and insulin resistance, eventually giving rise to impaired insulin secretion, often concomitant with hypoadiponectinemia. As an adipose tissue derived hormo
Externí odkaz:
https://doaj.org/article/2a4c59c398c7494fb3ba2aafae8e0020
Autor:
Anil K. Agarwal, Katie Tunison, Goncalo Vale, Jeffrey G. McDonald, Xilong Li, Philipp E. Scherer, Jay D. Horton, Abhimanyu Garg
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107806- (2023)
Summary: Genetic loss of Agpat2 in humans and mice results in congenital generalized lipodystrophy with near-total loss of adipose tissue and predisposition to develop insulin resistance, diabetes mellitus, hepatic steatosis, and hypertriglyceridemia
Externí odkaz:
https://doaj.org/article/cbfdbaa2bfeb492e96fa08ae536cb1d7
Autor:
Yi Zhu, Na Li, Mingyang Huang, Xi Chen, Yu A. An, Jianping Li, Shangang Zhao, Jan-Bernd Funcke, Jianhong Cao, Zhenyan He, Qingzhang Zhu, Zhuzhen Zhang, Zhao V. Wang, Lin Xu, Kevin W. Williams, Chien Li, Kevin Grove, Philipp E. Scherer
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 7, Pp 3063-3072 (2022)
Adipose tissue is a promising target for treating obesity and metabolic diseases. However, pharmacological agents usually fail to effectively engage adipocytes due to their extraordinarily large size and insufficient vascularization, especially in ob
Externí odkaz:
https://doaj.org/article/9f7116cbe4124a1d906ae08cbc4f4d5c
Autor:
Alex B. Smith, Jonah P. Schill, Ruth Gordillo, Grace E. Gustafson, Timothy W. Rhoads, Maggie S. Burhans, Aimee T. Broman, Ricki J. Colman, Philipp E. Scherer, Rozalyn M. Anderson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Metabolic syndrome increases risk of complicating co-morbidities. Current clinical indicators reflect established metabolic impairment, preventing earlier intervention strategies. Here we show that circulating sphingolipids are altered in th
Externí odkaz:
https://doaj.org/article/43f3986a7da74abcbd070096cce668a7
Autor:
Yu A. An, Wei Xiong, Shiuhwei Chen, Dawei Bu, Joseph M. Rutkowski, Joel P. Berger, Christine M. Kusminski, Ningyan Zhang, Zhiqiang An, Philipp E. Scherer
Publikováno v:
Molecular Metabolism, Vol 69, Iss , Pp 101680- (2023)
Objective: Renal fibrosis is a hallmark for chronic kidney disease (CKD), and often leads to end stage renal disease (ESRD). However, limited interventions are available clinically to ameliorate or reverse renal fibrosis. Methods: Herein, we evaluate
Externí odkaz:
https://doaj.org/article/6e8f7cde468443b19b2f998debea831b
Autor:
Zhenzhen Zi, Zhuzhen Zhang, Qiang Feng, Chiho Kim, Xu-Dong Wang, Philipp E. Scherer, Jinming Gao, Beth Levine, Yonghao Yu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
mTORC1, central regulator of cell growth and autophagy suppressor, is activated on the lysosome surface, but its local role in lysosomal biology remains unclear. Here the authors show STK11IP is a substrate of mTORC1 that regulates lysosomal acidific
Externí odkaz:
https://doaj.org/article/b73a4c77238140d09f96cfc934dc20ef
Autor:
Dae-Seok Kim, Philipp E. Scherer
Publikováno v:
Diabetes & Metabolism Journal, Vol 45, Iss 6, Pp 799-812 (2021)
Rates of obesity and diabetes have increased significantly over the past decades and the prevalence is expected to continue to rise further in the coming years. Many observations suggest that obesity and diabetes are associated with an increased risk
Externí odkaz:
https://doaj.org/article/27e76c839ca846129a8ef51a3ef5116d
Autor:
Yi Zhu, Na Li, Mingyang Huang, Mason Bartels, Sophie Dogné, Shangang Zhao, Xi Chen, Clair Crewe, Leon Straub, Lavanya Vishvanath, Zhuzhen Zhang, Mengle Shao, Yongjie Yang, Christy M. Gliniak, Ruth Gordillo, Gordon I. Smith, William L. Holland, Rana K. Gupta, Bingning Dong, Nathalie Caron, Yong Xu, Yucel Akgul, Samuel Klein, Philipp E. Scherer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Hyaluronan is a naturally occurring linear polysaccharide that together with collagens, enzymes, and glycoproteins forms the extracellular matrix. Here the authors show that adipose tissue overproduction of Hyaluronan reduces fat accumulation in mice
Externí odkaz:
https://doaj.org/article/d5d6f30432264ee3a4a2783133e16a29