Výsledky vyhledávání - "Philipp Dätwyler"

Akademický článek

Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells

Autor: Ana M. de Matos, Alice Martins, Teresa Man, David Evans, Magnus Walter, Maria Conceição Oliveira, Óscar López, José G. Fernandez-Bolaños, Philipp Dätwyler, Beat Ernst, M. Paula Macedo, Marialessandra Contino, Nicola A. Colabufo, Amélia P. Rauter

Publikováno v: Pharmaceuticals, Vol 12, Iss 2, p 98 (2019)

With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new neuroprotective treatments able to rescue neurons from cell injury is presently a matter of extreme importance and urgency. Here, we

Externí odkaz: https://doaj.org/article/d85cea01c0e04efc9bf99088013d51b6

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Prodrugs of E‐selectin Antagonists with Enhanced Pharmacokinetic Properties

Autor: Philipp Dätwyler, Xiaohua Jiang, Beatrice Wagner, Norbert Varga, Tobias Mühlethaler, Katja Hostettler, Said Rabbani, Oliver Schwardt, Beat Ernst

Publikováno v: ChemMedChem. 17

Because of their large polar surface area, carbohydrates often exhibit insufficient pharmacokinetic properties. Specifically, the carboxylic acid function of the tetrasaccharide sialyl Lewis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7ffff7aa6e792150e98598afdb505d
https://doi.org/10.1002/cmdc.202100634

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2-Deoxyglycosylation towards more effective and bioavailable neuroprotective molecules inspired by nature

Autor: Catarina Dias, Beat Ernst, Patrícia Calado, Alice Martins, Nicola Antonio Colabufo, Amélia P. Rauter, Maria Teresa Blásquez-Sanchez, Philipp Dätwyler, M. Paula Macedo, Ana M. Matos

Funding: The European Union is gratefully acknowledged for the support of the project “Diagnostic and Drug Discovery Initiative for Alzheimer’s Disease” (D3i4AD), FP7-PEOPLE-2013-IAPP, GA 612347. Fundação para a Ciência e a Tecnologia is als

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e947cd07b046135864438dfbce6fd55
https://hdl.handle.net/10362/147512

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Improvement of Aglycone π-Stacking Yields Nanomolar to Sub-nanomolar FimH Antagonists

Autor: Wojciech Schönemann, Jonathan Cramer, Tobias Mühlethaler, Brigitte Fiege, Marleen Silbermann, Said Rabbani, Philipp Dätwyler, Pascal Zihlmann, Roman P. Jakob, Christoph P. Sager, Martin Smieško, Oliver Schwardt, Timm Maier, Beat Ernst

Publikováno v: ChemMedChem. 14(7)

Antimicrobial resistance has become a serious concern for the treatment of urinary tract infections. In this context, an anti-adhesive approach targeting FimH, a bacterial lectin enabling the attachment of E. coli to host cells, has attracted conside

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70945bf7aa1a96e4bbab11414f60c8fa
https://pubmed.ncbi.nlm.nih.gov/30710416

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Prodruggability of carbohydrates — oral FimH antagonists

Autor: Oliver Schwardt, Simon Kleeb, Wojciech Schönemann, Philipp Dätwyler, Beat Ernst

Publikováno v: Canadian Journal of Chemistry. 94:909-919

The bacterial lectin FimH is a promising therapeutic target for the nonantibiotic prevention and treatment of urinary tract infections. In this communication, an ester prodrug approach is described to achieve oral bioavailability for FimH antagonists

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::748babfa13e99ad4d5500c98d8ac7e99
https://doi.org/10.1139/cjc-2015-0582

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Selective Inhibitors of Human Neuraminidase 3

Autor: Peng Ge, Christopher W. Cairo, Philipp Dätwyler, Michele R. Richards, Chunxia Zou, Ekaterina P. Demina, Alexey V. Pshezhetsky, Tianlin Guo, Ruixiang Blake Zheng, Beat Ernst, Anne Fougerat

Publikováno v: Journal of medicinal chemistry. 61(5)

Human neuraminidases (NEU) are associated with human diseases including cancer, atherosclerosis, and diabetes. To obtain small molecule inhibitors as research tools for the study of their biological functions, we designed a library of 2-deoxy-2,3-did

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84719e6f1a73560f30fe37f473db9d61
https://pubmed.ncbi.nlm.nih.gov/29425031

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Activities of N , N ′-Diarylurea MMV665852 Analogs against Schistosoma mansoni

Autor: Jonathan L. Vennerstrom, Noemi Cowan, Jennifer Keiser, Chunkai Wang, Beat Ernst, Philipp Dätwyler, Thomas Spangenberg

Publikováno v: Antimicrobial Agents and Chemotherapy. 59:1935-1941

There is an unmet need to discover and develop novel antischistosomal drugs. As exemplified by MMV665852, N , N ′-diarylureas have recently emerged as a promising antischistosomal chemotype. In this study, we evaluated the structure-activity relati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c61c45c445a5778f1547f5a61c42a8
https://doi.org/10.1128/aac.04463-14

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