Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Philipp Claar"'
Autor:
Steffi Knoll Machado, Hendrik Peil, Timo Kraushaar, Philipp Claar, Marcel Mischnik, Holger Lind, Eva Herzog, Michael Bacher, Marc Wolfgang Nolte, Maximilian Bielohuby, Sabine Pestel, Padmapriya Ponnuswamy
Publikováno v:
Thrombosis and Haemostasis.
Background: There is an emerging concept that in addition to circulating coagulation factor IX (FIX), extravascular FIX contributes to hemostasis. Objective: Evaluate efficacy of extravascular FIX using animal models of tail clip bleeding and ferric
Autor:
Anton Zalewski, Arna Andrews, Isabelle Glauser, Marcel Mischnik, Matthew P. Hardy, Anne M Verhagen, Kerstin Emmrich, Sabine Pestel, Con Panousis, Philipp Claar, Victor Turnbull, Chao-Guang Chen, Michael J. Wilson, Gregory T. Bass, Elmar Raquet, Steve K. Dower, Jenny Chia, Thomas Weimer, Vesna Tomasetig
Publikováno v:
Journal of Thrombosis and Haemostasis. 19:2710-2725
BACKGROUND We have recently reported on a recombinant von Willebrand factor (VWF) D'D3 albumin fusion protein (rD'D3-FP) developed to extend the half-life of coagulation factor VIII (FVIII) for the treatment of hemophilia A. Based on predictive model
Autor:
Steffi Knoll Machado, Hendrik Peil, Timo Kraushaar, Philipp Claar, Marcel Mischnik, Eva Herzog, Michael Bacher, Marc Wolfgang Nolte, Maximilian Bielohuby, Sabine Pestel, Padmapriya Ponnuswamy
Publikováno v:
Blood. 140:2701-2702
Autor:
J Röder, MW Nolte, T Kraushaar, M Bacher, Sabine Pestel, P Ponnuswamy, Philipp Claar, C Hardy, S Knoll Machado
Publikováno v:
65th Annual Meeting of the Society of Thrombosis and Haemostasis Research.
Autor:
Sabine Pestel, C Hardy, Philipp Claar, J Riedesel, K Schön, Marcel Mischnik, W Azar, W Seyfert-Brandt, MW Nolte
Publikováno v:
65th Annual Meeting of the Society of Thrombosis and Haemostasis Research.
Autor:
Elmar Raquet, Hendrik Peil, Padmapriya Ponnuswamy, Eva Herzog, Sabine Pestel, Marcel Mischnik, Philipp Claar, Steffi Knoll Machado, Oliver Ghobrial
Publikováno v:
Blood. 138:3180-3180
Introduction: The recessive X-linked bleeding disorder Hemophilia B is caused by a mutation in the coagulation factor (F) IX gene leading to partial or total loss of its function. Preventive treatment with replacement long-acting FIX is an attractive
Autor:
Jason Simmonds, Anna Tjärnlund-Wolf, Holger Lind, Arna Andrews, Philipp Claar, Stefan Schulte, Sabine Pestel, Steven K. Dower, Peter Schmidt, Marcel Mischnik, Thomas Weimer, Vesna Tomasetig, Elmar Raquet, Hans-Wilhelm Beltz
Publikováno v:
Blood Adv
A novel mechanism for extending the circulatory half-life of coagulation factor VIII (FVIII) has been established and evaluated preclinically. The FVIII binding domain of von Willebrand factor (D′D3) fused to human albumin (rD′D3-FP) dose depende
Autor:
Eva Herzog, Michael J. Wilson, Elmar Raquet, Marcel Mischnik, Arna Andrews, Sabine Pestel, Steve K. Dower, Philipp Claar, Thomas Weimer
Publikováno v:
Science meets clinical practice.
Autor:
Elmar Raquet, Sabine Zollner, Jochen Müller-Cohrs, Thomas Weimer, Philipp Claar, Hubert Metzner, Gerhard Dickneite, Ingo Pragst, Stefan Schulte
Publikováno v:
Thrombosis research. 134(1)
Introduction rVIII-SingleChain (CSL627), a novel recombinant coagulation factor VIII (FVIII), is under investigation in a phase I/III clinical programme (AFFINITY) for the treatment of haemophilia A. Non-clinical studies were conducted to investigate
Autor:
Eva Herzog, Elmar Raquet, Hendrik Peil, Philipp Claar, Jochen Müller-Cohrs, Sabine Pestel, Thomas Weimer
Publikováno v:
Blood. 126:1078-1078
Introduction: Current state of the art treatment of severe Hemophilia A is prophylactic or on-demand replacement of the deficient factor VIII (FVIII) using plasma derived or recombinant factors [Keeling 2008; Srivastava 2012; Wong 2011]. The complian