Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Philipp C. Rommel"'
Publikováno v:
Curr Opin Immunol
T cells engineered to express transgenes such as chimeric antigen receptors (CAR) or modified T cell receptors (TCR) represent a new pillar of cancer therapy. Use of CRISPR/Cas gene-editing tools now allows even stronger and more precise control over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e1e0550162f872096f8a157cab2be5
https://doi.org/10.1016/j.coi.2021.10.008
https://doi.org/10.1016/j.coi.2021.10.008
Autor:
Anusha Kalbasi, Mikko Siurala, Leon L. Su, Mito Tariveranmoshabad, Lora K. Picton, Pranali Ravikumar, Peng Li, Jian-Xin Lin, Helena Escuin-Ordinas, Tong Da, Sarah V. Kremer, Amy L. Sun, Sofia Castelli, Sangya Agarwal, John Scholler, Decheng Song, Philipp C. Rommel, Enrico Radaelli, Regina M. Young, Warren J. Leonard, Antoni Ribas, Carl H. June, K. Christopher Garcia
Publikováno v:
Nature, vol 607, iss 7918
Synthetic receptor signalling has the potential to endow adoptively transferred T cells with new functions that overcome major barriers in the treatment of solid tumours, including the need for conditioning chemotherapy1,2. Here we designed chimeric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e5dcbbb93da075e396a640fe01dad1
https://escholarship.org/uc/item/8sr3z3wt
https://escholarship.org/uc/item/8sr3z3wt
Autor:
Arito Yamane, Davide F. Robbiani, Wolfgang Resch, Anne Bothmer, Hirotaka Nakahashi, Thiago Oliveira, Philipp C. Rommel, Eric J. Brown, Andre Nussenzweig, Michel C. Nussenzweig, Rafael Casellas
Publikováno v:
Cell Reports, Vol 3, Iss 1, Pp 138-147 (2013)
Activation-induced cytidine deaminase (AID) promotes chromosomal translocations by inducing DNA double-strand breaks (DSBs) at immunoglobulin (Ig) genes and oncogenes in the G1 phase. RPA is a single-stranded DNA (ssDNA)-binding protein that associat
Externí odkaz:
https://doaj.org/article/aaf8f984f0064196a3769b21974613df
Autor:
M. Angela Aznar, Charly R. Good, Shunichiro Kuramitsu, Parisa Samareh, Sangya Agarwal, Greg Donahue, Kenichi Ishiyama, Nils Wellhausen, Austin K. Rennels, Yujie Ma, Lifeng Tian, Sonia Guedan, Katherine A. Alexander, Zhen Zhang, Philipp C. Rommel, Nathan Singh, Karl M. Glastad, Max W. Richardson, Keisuke Watanabe, Janos L. Tanyi, Mark H. O’Hara, Marco Ruella, Simon F. Lacey, Edmund K. Moon, Stephen J. Schuster, Steven M. Albelda, Lewis L. Lanier, Regina M. Young, Shelley L. Berger, Carl H. June
Publikováno v:
Cancer Research. 82:3602-3602
Chimeric antigen receptor (CAR) T cell immunotherapy is FDA approved for the treatment of a subset of B cell malignancies but has shown limited clinical success in solid tumor therapy. T cell exhaustion is an important factor involved in treatment fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1139f5b8839d87d9d1b304b86a68bc2c
https://doi.org/10.1158/1538-7445.am2022-3602
https://doi.org/10.1158/1538-7445.am2022-3602
Autor:
Anusha Kalbasi, Mikko Siurala, Leon L. Su, Mito Tariveranmoshabad, Lora K. Picton, Pranali Ravikumar, Peng Li, Jian-Xin Lin, Helena Escuin-Ordinas, Tong Da, Sarah V. Kremer, Amy L. Sun, Sofia Castelli, Sangya Agarwal, John Scholler, Decheng Song, Philipp C. Rommel, Enrico Radaelli, Regina M. Young, Warren J. Leonard, Antoni Ribas, Carl H. June, K. Christopher Garcia
Publikováno v:
Nature. 612:E10-E10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54ff6ce837e4c7e8082a951017456c5e
https://doi.org/10.1038/s41586-022-05548-6
https://doi.org/10.1038/s41586-022-05548-6
Autor:
Philipp C Rommel, David Bosque, Alexander D Gitlin, Gist F Croft, Nathaniel Heintz, Rafael Casellas, Michel C Nussenzweig, Skirmantas Kriaucionis, Davide F Robbiani
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69208 (2013)
The Aicda gene encodes Activation-Induced cytidine Deaminase (AID), an enzyme essential for remodeling antibody genes in mature B lymphocytes. AID is also responsible for DNA damage at oncogenes, leading to their mutation and cancer-associated chromo
Externí odkaz:
https://doaj.org/article/280d499ef7e6430089de18bc93d6c87d
Autor:
Keisuke Watanabe, Charly R. Good, Kenichi Ishiyama, Greg Donahue, Marco Ruella, Lewis L. Lanier, Simon F. Lacey, Nathan Singh, Janos L. Tanyi, Austin K. Rennels, Shunichiro Kuramitsu, Yujie Ma, Lifeng Tian, Shelley L. Berger, Karl M. Glastad, Mark H. O'Hara, Regina M. Young, Parisa Samareh, Zhen Zhang, Edmund K. Moon, Carl H. June, M. Angela Aznar, Philipp C. Rommel, Steven M. Albelda, Katherine A. Alexander, Sangya Agarwal, Stephen J. Schuster, Max W. Richardson, Nils Wellhausen, Sonia Guedan
Publikováno v:
Cell
Summary Chimeric antigen receptor (CAR) T cell therapy has achieved remarkable success in hematological malignancies but remains ineffective in solid tumors, due in part to CAR T cell exhaustion in the solid tumor microenvironment. To study dysfuncti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4dca3ac6b77cf3d1f795ac3d3904cd
https://pubmed.ncbi.nlm.nih.gov/34890549
https://pubmed.ncbi.nlm.nih.gov/34890549
Publikováno v:
The Journal of Experimental Medicine
Rommel et al. reveal a novel RAG1/2-mediated insertion pathway, which has the potential to destabilize the lymphocyte genome and shares features with DNA insertions observed in human cancer.
The RAG recombinase (RAG1/2) plays an essential role i
The RAG recombinase (RAG1/2) plays an essential role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba978515473fc88213f8c3a336cf04f
http://europepmc.org/articles/PMC5339680
http://europepmc.org/articles/PMC5339680
Autor:
Thiago Y. Oliveira, Michel C. Nussenzweig, Philipp C. Rommel, André Nussenzweig, Arito Yamane, Rafael Casellas, Hirotaka Nakahashi, Davide F. Robbiani, Anne Bothmer, Wolfgang Resch, Eric J. Brown
Publikováno v:
Cell Reports, Vol 3, Iss 1, Pp 138-147 (2013)
SummaryActivation-induced cytidine deaminase (AID) promotes chromosomal translocations by inducing DNA double-strand breaks (DSBs) at immunoglobulin (Ig) genes and oncogenes in the G1 phase. RPA is a single-stranded DNA (ssDNA)-binding protein that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee65481d02c2ca70caa7b4aa9448054
https://doi.org/10.1016/j.celrep.2012.12.006
https://doi.org/10.1016/j.celrep.2012.12.006
Autor:
Philipp C. Rommel, Daniel Finley, Tahel Noy, Lukas Jurzitza, Marion Schmidt, David M. Smith, Anne Legendre, Thomas Dange, Radames J. B. Cordero, Alfred L. Goldberg
Publikováno v:
Journal of Biological Chemistry. 286:42830-42839
For optimal proteolytic function, the central core of the proteasome (core particle (CP) or 20S) has to associate with activators. We investigated the impact of the yeast activator Blm10 on proteasomal peptide and protein degradation. We found enhanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e44bb784953c293c10d8363b0ff14c2
https://doi.org/10.1074/jbc.m111.300178
https://doi.org/10.1074/jbc.m111.300178